ES2118033A1 - Formulacion farmaceutica antiinflamatoria. - Google Patents

Formulacion farmaceutica antiinflamatoria.

Info

Publication number
ES2118033A1
ES2118033A1 ES09600374A ES9600374A ES2118033A1 ES 2118033 A1 ES2118033 A1 ES 2118033A1 ES 09600374 A ES09600374 A ES 09600374A ES 9600374 A ES9600374 A ES 9600374A ES 2118033 A1 ES2118033 A1 ES 2118033A1
Authority
ES
Spain
Prior art keywords
weight
pharmaceutically acceptable
nano
emulsion
pharmaceutical formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09600374A
Other languages
English (en)
Other versions
ES2118033B1 (es
Inventor
Pelaez Ricardo Palacios
Lopez Carlos Ruiz-Bravo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industrial Farmaceutica y de Especialidades SA
Original Assignee
Industrial Farmaceutica y de Especialidades SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industrial Farmaceutica y de Especialidades SA filed Critical Industrial Farmaceutica y de Especialidades SA
Priority to ES9600374A priority Critical patent/ES2118033B1/es
Priority to PCT/ES1997/000238 priority patent/WO1999016424A1/es
Publication of ES2118033A1 publication Critical patent/ES2118033A1/es
Application granted granted Critical
Publication of ES2118033B1 publication Critical patent/ES2118033B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

FORMULACION FARMACEUTICA ANTIINFLAMATORIA. FORMULACION FARMACEUTICA QUE CONTIENE UN EUTOMERO DE AL MENOS UN PRINCIPIO ACTIVO ANTIINFLAMATORIO, QUIRAL E HIDROINSOLUBLE, CON UN PH FISIOLOGICAMENTE ACEPTABLE, EN FORMA DE NANOEMULSION. LA NANOEMULSION CONTIENE 3 A 50% EN PESO DE UN SOLVENTE ORGANICO FARMACEUTICAMENTE ACEPTABLE, NO MISCIBLE EN AGUA, DE CARACTER APOLAR Y NO-IONICO QUE CONSTITUYE LA FASE INTERNA DE LA NANOEMULSION; 5 A 45% EN PESO DE UN AGENTE SURFACTANTE NO-IONICO FARMACEUTICAMENTE ACEPTABLE; 5 A 30% EN PESO DE UN AGENTE CO-SURFACTANTE NO-IONICO FARMACEUTICAMENTE ACEPTABLE; 5 A 87% EN PESO DE AGUA O DE UNA SOLUCION TAMPON FARMACEUTICAMENTE ACEPTABLE; COMO INGREDIENTE ACTIVO, 0,1 A 1,0% EN PESO DE UN EUTOMERO DE AL MENOS UN PRINCIPIO ANTIINFLAMATORIO, QUIRAL E HIDROINSOLUBLE; 0 A 6,5% DE AL MENOS UN EXCIPIENTE COMPLEMENTARIO FARMACEUTICAMENTE ACEPTABLE. EL INGREDIENTE ACTIVO ESTA VEHICULADO EN DISOLUCION MOLECULAR EN EL SOLVENTE ORGANICO.
ES9600374A 1996-02-16 1996-02-16 Formulacion farmaceutica antiinflamatoria. Expired - Fee Related ES2118033B1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9600374A ES2118033B1 (es) 1996-02-16 1996-02-16 Formulacion farmaceutica antiinflamatoria.
PCT/ES1997/000238 WO1999016424A1 (es) 1996-02-16 1997-09-30 Formulacion farmaceutica antiinflamatoria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9600374A ES2118033B1 (es) 1996-02-16 1996-02-16 Formulacion farmaceutica antiinflamatoria.
PCT/ES1997/000238 WO1999016424A1 (es) 1996-02-16 1997-09-30 Formulacion farmaceutica antiinflamatoria

Publications (2)

Publication Number Publication Date
ES2118033A1 true ES2118033A1 (es) 1998-09-01
ES2118033B1 ES2118033B1 (es) 1999-07-01

Family

ID=26154947

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9600374A Expired - Fee Related ES2118033B1 (es) 1996-02-16 1996-02-16 Formulacion farmaceutica antiinflamatoria.

Country Status (2)

Country Link
ES (1) ES2118033B1 (es)
WO (1) WO1999016424A1 (es)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042827A2 (en) * 1980-06-19 1981-12-30 Aktiebolaget Draco Pharmaceutical composition
WO1994005298A1 (en) * 1992-08-28 1994-03-17 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
WO1995031217A1 (en) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Tocopherol compositions for delivery of biologically active agents
EP0696452A1 (en) * 1994-08-08 1996-02-14 Laboratorios Cusi, S.A. Nanoemulsion of the oil in water type, useful as an ophthalmic vehicle and process for the preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8630273D0 (en) * 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
US5104656A (en) * 1989-06-16 1992-04-14 Seth Pyare L Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent
US5210099A (en) * 1991-02-11 1993-05-11 American Home Products Corporation Analgesic compositions
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042827A2 (en) * 1980-06-19 1981-12-30 Aktiebolaget Draco Pharmaceutical composition
WO1994005298A1 (en) * 1992-08-28 1994-03-17 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
WO1995031217A1 (en) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Tocopherol compositions for delivery of biologically active agents
EP0696452A1 (en) * 1994-08-08 1996-02-14 Laboratorios Cusi, S.A. Nanoemulsion of the oil in water type, useful as an ophthalmic vehicle and process for the preparation thereof

Also Published As

Publication number Publication date
WO1999016424A1 (es) 1999-04-08
ES2118033B1 (es) 1999-07-01

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