CA2202520A1 - Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation - Google Patents

Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation

Info

Publication number
CA2202520A1
CA2202520A1 CA2202520A CA2202520A CA2202520A1 CA 2202520 A1 CA2202520 A1 CA 2202520A1 CA 2202520 A CA2202520 A CA 2202520A CA 2202520 A CA2202520 A CA 2202520A CA 2202520 A1 CA2202520 A1 CA 2202520A1
Authority
CA
Canada
Prior art keywords
property
lyophilized pharmaceutical
gelation
pharmaceutical preparations
reversible thermosetting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2202520A
Other languages
French (fr)
Other versions
CA2202520C (en
Inventor
Masanobu Takeuchi
Hiroe Suzuki
Toshie Takahashi
Hiroki Maruyama
Miyako Sasaki
Keiko Naito
Touru Oguma
Makoto Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wakamoto Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002202520A priority Critical patent/CA2202520C/en
Priority claimed from PCT/JP1994/001709 external-priority patent/WO1996011672A1/en
Publication of CA2202520A1 publication Critical patent/CA2202520A1/en
Application granted granted Critical
Publication of CA2202520C publication Critical patent/CA2202520C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Herein disclosed is a lyophilized pharmaceutical preparation obtained by lyophilizing an aqueous composition having property of reversible thermosetting gelation and comprising an effective amount of a drug, 0.2 to 2.1 (W/V)% of methylcellulose (the content of methoxyl group is within the range of 26 to 33%), 1.2 to 2.3 (W/V)% of citric acid and 0.5 to 13- (W/V)% of polyethylene glycol. The lyophilized pharmaceutical preparation makes it possible to stably store drugs unstable to water till they are put into practical use and, upon therapeutic use, an aqueous composition having property of reversible thermosetting gelation which can undergo gelation when locally applied can easily and immediately be reconstituted from the preparation by addition of a proper amount of a solvent for reconstitution.
CA002202520A 1994-10-13 1994-10-13 Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation Expired - Fee Related CA2202520C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002202520A CA2202520C (en) 1994-10-13 1994-10-13 Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002202520A CA2202520C (en) 1994-10-13 1994-10-13 Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation
PCT/JP1994/001709 WO1996011672A1 (en) 1994-10-13 1994-10-13 Lyophilized preparation providing reversibly thermogelling water-base medicinal composition

Publications (2)

Publication Number Publication Date
CA2202520A1 true CA2202520A1 (en) 1996-04-25
CA2202520C CA2202520C (en) 2000-09-05

Family

ID=29421078

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002202520A Expired - Fee Related CA2202520C (en) 1994-10-13 1994-10-13 Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation

Country Status (1)

Country Link
CA (1) CA2202520C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023059846A1 (en) * 2021-10-08 2023-04-13 President And Fellows Of Harvard College Ionic liquids for drug delivery

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023059846A1 (en) * 2021-10-08 2023-04-13 President And Fellows Of Harvard College Ionic liquids for drug delivery

Also Published As

Publication number Publication date
CA2202520C (en) 2000-09-05

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed