UA39095C2 - Інгібітор атеросклеротичного потовщення внутрішньої оболонки судин - Google Patents
Інгібітор атеросклеротичного потовщення внутрішньої оболонки судинInfo
- Publication number
- UA39095C2 UA39095C2 UA93002706A UA93002706A UA39095C2 UA 39095 C2 UA39095 C2 UA 39095C2 UA 93002706 A UA93002706 A UA 93002706A UA 93002706 A UA93002706 A UA 93002706A UA 39095 C2 UA39095 C2 UA 39095C2
- Authority
- UA
- Ukraine
- Prior art keywords
- antisclerotic
- thickening
- vessels
- inhibitor
- inner coat
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Предметом цього винаходу є інгібітор атеросклерозного потовщення внутрішньої оболонки судин, який представляє похідне піридину, що має сильну інгібуючу дію відносно HMG-CoA редуктази, а також сильну інгібуючу дію відносно проліферації кліток гладких м'язів внутрішньої оболонки аорти.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP03257870A JP3130342B2 (ja) | 1991-10-04 | 1991-10-04 | 動脈硬化性血管内膜肥厚抑制薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA39095C2 true UA39095C2 (uk) | 2001-06-15 |
Family
ID=17312323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93002706A UA39095C2 (uk) | 1991-10-04 | 1993-04-22 | Інгібітор атеросклеротичного потовщення внутрішньої оболонки судин |
Country Status (18)
Country | Link |
---|---|
US (1) | US6162798A (uk) |
EP (1) | EP0535548B1 (uk) |
JP (1) | JP3130342B2 (uk) |
KR (1) | KR100264543B1 (uk) |
AT (1) | ATE209035T1 (uk) |
AU (1) | AU652669B2 (uk) |
CA (1) | CA2079706C (uk) |
CZ (1) | CZ281786B6 (uk) |
DE (1) | DE69232217T2 (uk) |
DK (1) | DK0535548T3 (uk) |
HU (1) | HU214624B (uk) |
MX (1) | MX9205659A (uk) |
NO (1) | NO302452B1 (uk) |
NZ (1) | NZ244555A (uk) |
RU (1) | RU2114620C1 (uk) |
SK (1) | SK279277B6 (uk) |
TW (1) | TW238300B (uk) |
UA (1) | UA39095C2 (uk) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995011898A1 (en) * | 1992-05-12 | 1995-05-04 | Nissan Chemical Industries Ltd. | Condensed pyridine type mevalonolactone intermediate and process for its production |
ATE243034T1 (de) * | 1996-01-17 | 2003-07-15 | Taiho Pharmaceutical Co Ltd | Intimale verdickungsinhibitoren |
MXPA01000890A (es) * | 1998-07-23 | 2002-06-04 | Nissan Chemical Ind Ltd | Procedimiento para producir un derivado de quinolina e intermediario. |
SK8512001A3 (en) * | 1999-01-14 | 2001-12-03 | Nissan Chemical Ind Ltd | Process for producing quinolinecarbaldehyde |
CN1222512C (zh) * | 2000-01-24 | 2005-10-12 | 日产化学工业株式会社 | 喹啉基丙烯醛的制备方法 |
JP4496586B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルアクリロニトリルの製造法及びその中間体 |
JP4496585B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルプロペナールの製造方法 |
JP4496584B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルプロペナールの製造法 |
CA2400977C (en) * | 2000-02-21 | 2011-03-22 | Kuraray Co., Ltd. | Processes for preparing quinoline derivatives and intermediates thereof |
JP4867071B2 (ja) * | 2000-02-21 | 2012-02-01 | 日産化学工業株式会社 | キノリン誘導体の製造方法 |
WO2001098301A1 (fr) * | 2000-06-20 | 2001-12-27 | Japan Tobacco Inc. | Composes de pyrazolopyridine et utilisation de ces derniers en tant que medicaments |
AU2003213682C1 (en) * | 2002-03-04 | 2008-06-12 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin alphavbeta3 antagonist in combination with an HMG-CoA reductase inhibitor or a bisphosphonate |
CN100378077C (zh) * | 2002-11-06 | 2008-04-02 | 日产化学工业株式会社 | 喹啉甲醛类的制造方法 |
WO2004041787A1 (ja) * | 2002-11-06 | 2004-05-21 | Nissan Chemical Industries, Ltd. | キノリンカルバルデヒド類の製造方法 |
US7420059B2 (en) | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
BRPI0417543A (pt) | 2003-12-12 | 2007-03-27 | Wyeth Corp | quinolinas úteis no tratamento de doença cardiovascular |
DE602005011286D1 (en) * | 2004-07-05 | 2009-01-08 | Astellas Pharma Inc | Pyrazolopyridinderivate |
CN100445267C (zh) * | 2005-10-21 | 2008-12-24 | 上海医药工业研究院 | 4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法 |
NZ702571A (en) | 2012-06-29 | 2017-02-24 | Pfizer | 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
CN103204807B (zh) * | 2013-04-08 | 2015-12-23 | 黄河三角洲京博化工研究院有限公司 | 一种2-环丙基-4-(4-氟-苯基)-3-喹啉甲醛的合成方法 |
WO2015087994A1 (ja) * | 2013-12-13 | 2015-06-18 | 第一三共株式会社 | 5-ヒドロキシ-4-(トリフルオロメチル)ピラゾロピリジン誘導体 |
JP6487921B2 (ja) | 2013-12-17 | 2019-03-20 | ファイザー・インク | LRRK2阻害薬としての新規の3,4−二置換−1H−ピロロ[2,3−b]ピリジンおよび4,5−二置換−7H−ピロロ[2,3−c]ピリダジン |
CN104031034B (zh) * | 2014-07-01 | 2017-01-04 | 上海信谊百路达药业有限公司 | 一种匹伐他汀钙原料药中间体的制备方法 |
CN108137586B (zh) | 2015-09-14 | 2021-04-13 | 辉瑞大药厂 | 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
JP2569746B2 (ja) * | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
US4761419A (en) * | 1987-12-07 | 1988-08-02 | Warner-Lambert Company | 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US4822799A (en) * | 1988-01-27 | 1989-04-18 | Sandoz Pharm. Corp. | Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals |
US5024999A (en) * | 1988-04-26 | 1991-06-18 | Nissan Chemical Industries Ltd. | Pyrazolopyridine type mevalonolactones useful as pharmaeuticals |
JP2890448B2 (ja) * | 1988-04-26 | 1999-05-17 | 日産化学工業株式会社 | ピラゾロピリジン系メバロノラクトン類 |
US5026698A (en) * | 1988-11-02 | 1991-06-25 | Nissan Chemical Industries, Ltd. | Thienopyridine type mevalonolactones |
-
1991
- 1991-10-04 JP JP03257870A patent/JP3130342B2/ja not_active Expired - Fee Related
-
1992
- 1992-09-24 EP EP92116417A patent/EP0535548B1/en not_active Expired - Lifetime
- 1992-09-24 AT AT92116417T patent/ATE209035T1/de not_active IP Right Cessation
- 1992-09-24 DE DE69232217T patent/DE69232217T2/de not_active Expired - Lifetime
- 1992-09-24 DK DK92116417T patent/DK0535548T3/da active
- 1992-09-28 AU AU26012/92A patent/AU652669B2/en not_active Ceased
- 1992-09-30 NZ NZ244555A patent/NZ244555A/en not_active IP Right Cessation
- 1992-09-30 US US07/953,716 patent/US6162798A/en not_active Expired - Fee Related
- 1992-10-01 TW TW081107817A patent/TW238300B/zh not_active IP Right Cessation
- 1992-10-02 MX MX9205659A patent/MX9205659A/es unknown
- 1992-10-02 HU HU9203138A patent/HU214624B/hu not_active IP Right Cessation
- 1992-10-02 CA CA002079706A patent/CA2079706C/en not_active Expired - Fee Related
- 1992-10-02 SK SK3027-92A patent/SK279277B6/sk not_active IP Right Cessation
- 1992-10-02 NO NO923858A patent/NO302452B1/no not_active IP Right Cessation
- 1992-10-02 RU SU5052949A patent/RU2114620C1/ru active
- 1992-10-02 KR KR1019920018157A patent/KR100264543B1/ko not_active IP Right Cessation
- 1992-10-02 CZ CS923027A patent/CZ281786B6/cs not_active IP Right Cessation
-
1993
- 1993-04-22 UA UA93002706A patent/UA39095C2/uk unknown
Also Published As
Publication number | Publication date |
---|---|
DE69232217D1 (de) | 2002-01-03 |
AU2601292A (en) | 1993-04-08 |
HU214624B (hu) | 1998-04-28 |
MX9205659A (es) | 1993-04-01 |
AU652669B2 (en) | 1994-09-01 |
CA2079706A1 (en) | 1993-04-15 |
US6162798A (en) | 2000-12-19 |
JPH06329540A (ja) | 1994-11-29 |
SK279277B6 (sk) | 1998-09-09 |
CA2079706C (en) | 2004-03-30 |
HUT62794A (en) | 1993-06-28 |
RU2114620C1 (ru) | 1998-07-10 |
CZ281786B6 (cs) | 1997-01-15 |
KR930007449A (ko) | 1993-05-20 |
CZ302792A3 (en) | 1993-10-13 |
DE69232217T2 (de) | 2002-05-23 |
TW238300B (uk) | 1995-01-11 |
ATE209035T1 (de) | 2001-12-15 |
NZ244555A (en) | 2000-06-23 |
KR100264543B1 (ko) | 2001-10-24 |
SK302792A3 (en) | 1995-11-08 |
EP0535548A1 (en) | 1993-04-07 |
EP0535548B1 (en) | 2001-11-21 |
NO923858D0 (no) | 1992-10-02 |
DK0535548T3 (da) | 2002-05-13 |
NO923858L (no) | 1993-04-05 |
JP3130342B2 (ja) | 2001-01-31 |
NO302452B1 (no) | 1998-03-09 |
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