MX9205659A - Inhibidor del engrosamiento interno ateroesclerotico. - Google Patents

Inhibidor del engrosamiento interno ateroesclerotico.

Info

Publication number
MX9205659A
MX9205659A MX9205659A MX9205659A MX9205659A MX 9205659 A MX9205659 A MX 9205659A MX 9205659 A MX9205659 A MX 9205659A MX 9205659 A MX9205659 A MX 9205659A MX 9205659 A MX9205659 A MX 9205659A
Authority
MX
Mexico
Prior art keywords
alkyl
hydrogen
butoxy
chem
tert
Prior art date
Application number
MX9205659A
Other languages
English (en)
Inventor
Yasushi Saito
Masaki Kitahara
Mitsuaki Sakashita
Kyomi Toyoda
Toshie Shibazaki
Original Assignee
Nissan Chemical Ind Ltd
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd, Kowa Co filed Critical Nissan Chemical Ind Ltd
Publication of MX9205659A publication Critical patent/MX9205659A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MX9205659A 1991-10-04 1992-10-02 Inhibidor del engrosamiento interno ateroesclerotico. MX9205659A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP03257870A JP3130342B2 (ja) 1991-10-04 1991-10-04 動脈硬化性血管内膜肥厚抑制薬

Publications (1)

Publication Number Publication Date
MX9205659A true MX9205659A (es) 1993-04-01

Family

ID=17312323

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9205659A MX9205659A (es) 1991-10-04 1992-10-02 Inhibidor del engrosamiento interno ateroesclerotico.

Country Status (18)

Country Link
US (1) US6162798A (es)
EP (1) EP0535548B1 (es)
JP (1) JP3130342B2 (es)
KR (1) KR100264543B1 (es)
AT (1) ATE209035T1 (es)
AU (1) AU652669B2 (es)
CA (1) CA2079706C (es)
CZ (1) CZ281786B6 (es)
DE (1) DE69232217T2 (es)
DK (1) DK0535548T3 (es)
HU (1) HU214624B (es)
MX (1) MX9205659A (es)
NO (1) NO302452B1 (es)
NZ (1) NZ244555A (es)
RU (1) RU2114620C1 (es)
SK (1) SK279277B6 (es)
TW (1) TW238300B (es)
UA (1) UA39095C2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011898A1 (en) * 1992-05-12 1995-05-04 Nissan Chemical Industries Ltd. Condensed pyridine type mevalonolactone intermediate and process for its production
HUP9800757A3 (en) * 1996-01-17 1998-08-28 Taiho Pharmaceutical Co Ltd Intimal thickening inhibitors containing oxyindole derivatives and pharmaceutical compositions containing them
CZ299881B6 (cs) * 1998-07-23 2008-12-17 Nissan Chemical Industries, Ltd. Nitrilová sloucenina a zpusob výroby chinolinového derivátu
JP4714992B2 (ja) * 1999-01-14 2011-07-06 日産化学工業株式会社 キノリンカルボアルデヒドの製造法
CN1222512C (zh) * 2000-01-24 2005-10-12 日产化学工业株式会社 喹啉基丙烯醛的制备方法
JP4496586B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルアクリロニトリルの製造法及びその中間体
JP4496585B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルプロペナールの製造方法
JP4496584B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルプロペナールの製造法
WO2001060800A1 (fr) 2000-02-21 2001-08-23 Kuraray Co., Ltd. Procedes de preparation de derives de quinoline et de leurs intermediaires
JP4867071B2 (ja) * 2000-02-21 2012-02-01 日産化学工業株式会社 キノリン誘導体の製造方法
WO2001098301A1 (fr) * 2000-06-20 2001-12-27 Japan Tobacco Inc. Composes de pyrazolopyridine et utilisation de ces derniers en tant que medicaments
CA2478317A1 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate
AU2003277572A1 (en) * 2002-11-06 2004-06-07 Nissan Chemical Industries, Ltd. Process for producing quinolinecarbaldehyde
CN100378077C (zh) * 2002-11-06 2008-04-02 日产化学工业株式会社 喹啉甲醛类的制造方法
US7420059B2 (en) * 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
WO2005058834A2 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
DE602005011286D1 (en) * 2004-07-05 2009-01-08 Astellas Pharma Inc Pyrazolopyridinderivate
CN100445267C (zh) * 2005-10-21 2008-12-24 上海医药工业研究院 4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法
MX2014015769A (es) 2012-06-29 2015-04-10 Pfizer 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas)novedosas como inhibidores de lrrk2.
CN103204807B (zh) * 2013-04-08 2015-12-23 黄河三角洲京博化工研究院有限公司 一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法
MX368576B (es) * 2013-12-13 2019-10-08 Daiichi Sankyo Co Ltd Derivados de 5-hidroxi-4-(trifluorometil)pirazolopiridina.
WO2015092592A1 (en) 2013-12-17 2015-06-25 Pfizer Inc. Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
CN104031034B (zh) * 2014-07-01 2017-01-04 上海信谊百路达药业有限公司 一种匹伐他汀钙原料药中间体的制备方法
WO2017046675A1 (en) 2015-09-14 2017-03-23 Pfizer Inc. Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
US4761419A (en) * 1987-12-07 1988-08-02 Warner-Lambert Company 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
JP2890448B2 (ja) * 1988-04-26 1999-05-17 日産化学工業株式会社 ピラゾロピリジン系メバロノラクトン類
US5024999A (en) * 1988-04-26 1991-06-18 Nissan Chemical Industries Ltd. Pyrazolopyridine type mevalonolactones useful as pharmaeuticals
US5026698A (en) * 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones

Also Published As

Publication number Publication date
UA39095C2 (uk) 2001-06-15
US6162798A (en) 2000-12-19
SK302792A3 (en) 1995-11-08
DE69232217D1 (de) 2002-01-03
NO302452B1 (no) 1998-03-09
EP0535548B1 (en) 2001-11-21
RU2114620C1 (ru) 1998-07-10
HU214624B (hu) 1998-04-28
NZ244555A (en) 2000-06-23
ATE209035T1 (de) 2001-12-15
KR930007449A (ko) 1993-05-20
HUT62794A (en) 1993-06-28
CA2079706A1 (en) 1993-04-15
NO923858D0 (no) 1992-10-02
KR100264543B1 (ko) 2001-10-24
AU2601292A (en) 1993-04-08
SK279277B6 (sk) 1998-09-09
NO923858L (no) 1993-04-05
JPH06329540A (ja) 1994-11-29
CZ302792A3 (en) 1993-10-13
JP3130342B2 (ja) 2001-01-31
DE69232217T2 (de) 2002-05-23
AU652669B2 (en) 1994-09-01
EP0535548A1 (en) 1993-04-07
CA2079706C (en) 2004-03-30
DK0535548T3 (da) 2002-05-13
TW238300B (es) 1995-01-11
CZ281786B6 (cs) 1997-01-15

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