MX9205659A - Inhibidor del engrosamiento interno ateroesclerotico. - Google Patents
Inhibidor del engrosamiento interno ateroesclerotico.Info
- Publication number
- MX9205659A MX9205659A MX9205659A MX9205659A MX9205659A MX 9205659 A MX9205659 A MX 9205659A MX 9205659 A MX9205659 A MX 9205659A MX 9205659 A MX9205659 A MX 9205659A MX 9205659 A MX9205659 A MX 9205659A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- hydrogen
- butoxy
- chem
- tert
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP03257870A JP3130342B2 (ja) | 1991-10-04 | 1991-10-04 | 動脈硬化性血管内膜肥厚抑制薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9205659A true MX9205659A (es) | 1993-04-01 |
Family
ID=17312323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9205659A MX9205659A (es) | 1991-10-04 | 1992-10-02 | Inhibidor del engrosamiento interno ateroesclerotico. |
Country Status (18)
Country | Link |
---|---|
US (1) | US6162798A (es) |
EP (1) | EP0535548B1 (es) |
JP (1) | JP3130342B2 (es) |
KR (1) | KR100264543B1 (es) |
AT (1) | ATE209035T1 (es) |
AU (1) | AU652669B2 (es) |
CA (1) | CA2079706C (es) |
CZ (1) | CZ281786B6 (es) |
DE (1) | DE69232217T2 (es) |
DK (1) | DK0535548T3 (es) |
HU (1) | HU214624B (es) |
MX (1) | MX9205659A (es) |
NO (1) | NO302452B1 (es) |
NZ (1) | NZ244555A (es) |
RU (1) | RU2114620C1 (es) |
SK (1) | SK279277B6 (es) |
TW (1) | TW238300B (es) |
UA (1) | UA39095C2 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995011898A1 (en) * | 1992-05-12 | 1995-05-04 | Nissan Chemical Industries Ltd. | Condensed pyridine type mevalonolactone intermediate and process for its production |
HUP9800757A3 (en) * | 1996-01-17 | 1998-08-28 | Taiho Pharmaceutical Co Ltd | Intimal thickening inhibitors containing oxyindole derivatives and pharmaceutical compositions containing them |
CZ299881B6 (cs) * | 1998-07-23 | 2008-12-17 | Nissan Chemical Industries, Ltd. | Nitrilová sloucenina a zpusob výroby chinolinového derivátu |
JP4714992B2 (ja) * | 1999-01-14 | 2011-07-06 | 日産化学工業株式会社 | キノリンカルボアルデヒドの製造法 |
CN1222512C (zh) * | 2000-01-24 | 2005-10-12 | 日产化学工业株式会社 | 喹啉基丙烯醛的制备方法 |
JP4496586B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルアクリロニトリルの製造法及びその中間体 |
JP4496585B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルプロペナールの製造方法 |
JP4496584B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルプロペナールの製造法 |
WO2001060800A1 (fr) | 2000-02-21 | 2001-08-23 | Kuraray Co., Ltd. | Procedes de preparation de derives de quinoline et de leurs intermediaires |
JP4867071B2 (ja) * | 2000-02-21 | 2012-02-01 | 日産化学工業株式会社 | キノリン誘導体の製造方法 |
WO2001098301A1 (fr) * | 2000-06-20 | 2001-12-27 | Japan Tobacco Inc. | Composes de pyrazolopyridine et utilisation de ces derniers en tant que medicaments |
CA2478317A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate |
AU2003277572A1 (en) * | 2002-11-06 | 2004-06-07 | Nissan Chemical Industries, Ltd. | Process for producing quinolinecarbaldehyde |
CN100378077C (zh) * | 2002-11-06 | 2008-04-02 | 日产化学工业株式会社 | 喹啉甲醛类的制造方法 |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
WO2005058834A2 (en) | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
DE602005011286D1 (en) * | 2004-07-05 | 2009-01-08 | Astellas Pharma Inc | Pyrazolopyridinderivate |
CN100445267C (zh) * | 2005-10-21 | 2008-12-24 | 上海医药工业研究院 | 4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法 |
MX2014015769A (es) | 2012-06-29 | 2015-04-10 | Pfizer | 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas)novedosas como inhibidores de lrrk2. |
CN103204807B (zh) * | 2013-04-08 | 2015-12-23 | 黄河三角洲京博化工研究院有限公司 | 一种2-环丙基-4-(4-氟-苯基)-3-喹啉甲醛的合成方法 |
MX368576B (es) * | 2013-12-13 | 2019-10-08 | Daiichi Sankyo Co Ltd | Derivados de 5-hidroxi-4-(trifluorometil)pirazolopiridina. |
WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
CN104031034B (zh) * | 2014-07-01 | 2017-01-04 | 上海信谊百路达药业有限公司 | 一种匹伐他汀钙原料药中间体的制备方法 |
WO2017046675A1 (en) | 2015-09-14 | 2017-03-23 | Pfizer Inc. | Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1336714C (en) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
JP2569746B2 (ja) * | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
US4761419A (en) * | 1987-12-07 | 1988-08-02 | Warner-Lambert Company | 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US4822799A (en) * | 1988-01-27 | 1989-04-18 | Sandoz Pharm. Corp. | Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals |
JP2890448B2 (ja) * | 1988-04-26 | 1999-05-17 | 日産化学工業株式会社 | ピラゾロピリジン系メバロノラクトン類 |
US5024999A (en) * | 1988-04-26 | 1991-06-18 | Nissan Chemical Industries Ltd. | Pyrazolopyridine type mevalonolactones useful as pharmaeuticals |
US5026698A (en) * | 1988-11-02 | 1991-06-25 | Nissan Chemical Industries, Ltd. | Thienopyridine type mevalonolactones |
-
1991
- 1991-10-04 JP JP03257870A patent/JP3130342B2/ja not_active Expired - Fee Related
-
1992
- 1992-09-24 AT AT92116417T patent/ATE209035T1/de not_active IP Right Cessation
- 1992-09-24 EP EP92116417A patent/EP0535548B1/en not_active Expired - Lifetime
- 1992-09-24 DK DK92116417T patent/DK0535548T3/da active
- 1992-09-24 DE DE69232217T patent/DE69232217T2/de not_active Expired - Lifetime
- 1992-09-28 AU AU26012/92A patent/AU652669B2/en not_active Ceased
- 1992-09-30 NZ NZ244555A patent/NZ244555A/en not_active IP Right Cessation
- 1992-09-30 US US07/953,716 patent/US6162798A/en not_active Expired - Fee Related
- 1992-10-01 TW TW081107817A patent/TW238300B/zh not_active IP Right Cessation
- 1992-10-02 HU HU9203138A patent/HU214624B/hu not_active IP Right Cessation
- 1992-10-02 CZ CS923027A patent/CZ281786B6/cs not_active IP Right Cessation
- 1992-10-02 SK SK3027-92A patent/SK279277B6/sk not_active IP Right Cessation
- 1992-10-02 CA CA002079706A patent/CA2079706C/en not_active Expired - Fee Related
- 1992-10-02 RU SU5052949A patent/RU2114620C1/ru active
- 1992-10-02 KR KR1019920018157A patent/KR100264543B1/ko not_active IP Right Cessation
- 1992-10-02 MX MX9205659A patent/MX9205659A/es unknown
- 1992-10-02 NO NO923858A patent/NO302452B1/no not_active IP Right Cessation
-
1993
- 1993-04-22 UA UA93002706A patent/UA39095C2/uk unknown
Also Published As
Publication number | Publication date |
---|---|
UA39095C2 (uk) | 2001-06-15 |
US6162798A (en) | 2000-12-19 |
SK302792A3 (en) | 1995-11-08 |
DE69232217D1 (de) | 2002-01-03 |
NO302452B1 (no) | 1998-03-09 |
EP0535548B1 (en) | 2001-11-21 |
RU2114620C1 (ru) | 1998-07-10 |
HU214624B (hu) | 1998-04-28 |
NZ244555A (en) | 2000-06-23 |
ATE209035T1 (de) | 2001-12-15 |
KR930007449A (ko) | 1993-05-20 |
HUT62794A (en) | 1993-06-28 |
CA2079706A1 (en) | 1993-04-15 |
NO923858D0 (no) | 1992-10-02 |
KR100264543B1 (ko) | 2001-10-24 |
AU2601292A (en) | 1993-04-08 |
SK279277B6 (sk) | 1998-09-09 |
NO923858L (no) | 1993-04-05 |
JPH06329540A (ja) | 1994-11-29 |
CZ302792A3 (en) | 1993-10-13 |
JP3130342B2 (ja) | 2001-01-31 |
DE69232217T2 (de) | 2002-05-23 |
AU652669B2 (en) | 1994-09-01 |
EP0535548A1 (en) | 1993-04-07 |
CA2079706C (en) | 2004-03-30 |
DK0535548T3 (da) | 2002-05-13 |
TW238300B (es) | 1995-01-11 |
CZ281786B6 (cs) | 1997-01-15 |
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