ATE15198T1 - Blutdrucksenkende 1-substituierte spiro(piperidin-oxobenzoxazine). - Google Patents
Blutdrucksenkende 1-substituierte spiro(piperidin-oxobenzoxazine).Info
- Publication number
- ATE15198T1 ATE15198T1 AT82302494T AT82302494T ATE15198T1 AT E15198 T1 ATE15198 T1 AT E15198T1 AT 82302494 T AT82302494 T AT 82302494T AT 82302494 T AT82302494 T AT 82302494T AT E15198 T1 ATE15198 T1 AT E15198T1
- Authority
- AT
- Austria
- Prior art keywords
- omega
- aryl
- halo
- lower alkyl
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/264,779 US4349549A (en) | 1981-05-18 | 1981-05-18 | Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s |
EP82302494A EP0065864B1 (de) | 1981-05-18 | 1982-05-17 | Blutdrucksenkende 1-substituierte Spiro(piperidin-oxobenzoxazine) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE15198T1 true ATE15198T1 (de) | 1985-09-15 |
Family
ID=23007572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT82302494T ATE15198T1 (de) | 1981-05-18 | 1982-05-17 | Blutdrucksenkende 1-substituierte spiro(piperidin-oxobenzoxazine). |
Country Status (20)
Country | Link |
---|---|
US (1) | US4349549A (de) |
EP (1) | EP0065864B1 (de) |
JP (1) | JPS57193485A (de) |
KR (1) | KR830010115A (de) |
AT (1) | ATE15198T1 (de) |
AU (1) | AU8376982A (de) |
BR (1) | BR8202861A (de) |
DE (1) | DE3265802D1 (de) |
DK (1) | DK221882A (de) |
ES (3) | ES512275A0 (de) |
FI (1) | FI821733A0 (de) |
HU (1) | HU186933B (de) |
IE (1) | IE53034B1 (de) |
IL (1) | IL65801A (de) |
NO (1) | NO821616L (de) |
NZ (1) | NZ200631A (de) |
PH (1) | PH20072A (de) |
PL (2) | PL246771A1 (de) |
PT (1) | PT74912B (de) |
ZA (1) | ZA823414B (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5815979A (ja) * | 1981-07-11 | 1983-01-29 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体およびその製造法 |
JPS5959685A (ja) * | 1982-09-28 | 1984-04-05 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
GB2131021B (en) * | 1982-11-24 | 1985-12-18 | Erba Farmitalia | Antipsychotic benzoxazines |
US4558049A (en) * | 1982-11-24 | 1985-12-10 | Farmitalia Carlo Erba S.P.A. | Antipsycotic benzoxazines |
IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
SE9202218D0 (sv) * | 1992-07-22 | 1992-07-22 | Kabi Pharmacia Ab | Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation |
US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
WO2001045707A1 (en) * | 1999-12-21 | 2001-06-28 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2001230537A1 (en) * | 2000-02-01 | 2001-08-14 | Daiichi Pharmaceutical Co., Ltd. | Pyridoxazine derivatives |
US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
EP2374455A3 (de) * | 2004-08-19 | 2012-03-28 | Vertex Pharmaceuticals Incorporated | Modulatoren von muskarinischen Rezeptoren |
RU2007124373A (ru) * | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
RU2008130094A (ru) * | 2005-12-22 | 2010-01-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
US7351706B2 (en) * | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
WO2007100670A1 (en) * | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Spiro condensed piperidnes as modulators of muscarinic receptors |
CN101426499A (zh) * | 2006-02-22 | 2009-05-06 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
EP2040706A2 (de) * | 2006-06-29 | 2009-04-01 | Vertex Pharmceuticals Incorporated | Modulatoren muskarinischer rezeptoren |
JP2010500412A (ja) * | 2006-08-15 | 2010-01-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
CN101573121A (zh) * | 2006-08-18 | 2009-11-04 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
WO2009045519A1 (en) * | 2007-10-03 | 2009-04-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
CN113264949B (zh) * | 2021-05-31 | 2022-04-05 | 西南大学 | 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA952908A (en) * | 1970-02-27 | 1974-08-13 | Yoshitomi Pharmaceutical Industries | Benzodioxane derivatives |
FR2420536A1 (fr) * | 1978-03-22 | 1979-10-19 | Roussel Uclaf | Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments |
-
1981
- 1981-05-18 US US06/264,779 patent/US4349549A/en not_active Expired - Fee Related
-
1982
- 1982-05-14 NO NO821616A patent/NO821616L/no unknown
- 1982-05-14 PH PH27300A patent/PH20072A/en unknown
- 1982-05-17 AT AT82302494T patent/ATE15198T1/de active
- 1982-05-17 JP JP57081739A patent/JPS57193485A/ja active Pending
- 1982-05-17 ZA ZA823414A patent/ZA823414B/xx unknown
- 1982-05-17 DE DE8282302494T patent/DE3265802D1/de not_active Expired
- 1982-05-17 FI FI821733A patent/FI821733A0/fi not_active Application Discontinuation
- 1982-05-17 IE IE1179/82A patent/IE53034B1/en unknown
- 1982-05-17 NZ NZ200631A patent/NZ200631A/en unknown
- 1982-05-17 KR KR1019820002137A patent/KR830010115A/ko unknown
- 1982-05-17 ES ES512275A patent/ES512275A0/es active Granted
- 1982-05-17 EP EP82302494A patent/EP0065864B1/de not_active Expired
- 1982-05-17 HU HU821547A patent/HU186933B/hu unknown
- 1982-05-17 AU AU83769/82A patent/AU8376982A/en not_active Abandoned
- 1982-05-17 PT PT74912A patent/PT74912B/pt unknown
- 1982-05-17 DK DK221882A patent/DK221882A/da not_active Application Discontinuation
- 1982-05-17 PL PL24677182A patent/PL246771A1/xx unknown
- 1982-05-17 BR BR8202861A patent/BR8202861A/pt unknown
- 1982-05-17 PL PL23647282A patent/PL236472A1/xx unknown
- 1982-05-17 IL IL65801A patent/IL65801A/xx unknown
-
1983
- 1983-03-30 ES ES521124A patent/ES521124A0/es active Granted
- 1983-03-30 ES ES521125A patent/ES8404791A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8404790A1 (es) | 1984-06-01 |
EP0065864A1 (de) | 1982-12-01 |
ZA823414B (en) | 1983-12-28 |
AU8376982A (en) | 1982-11-25 |
US4349549A (en) | 1982-09-14 |
EP0065864B1 (de) | 1985-08-28 |
ES521124A0 (es) | 1984-06-01 |
PT74912B (en) | 1983-12-07 |
IL65801A0 (en) | 1982-08-31 |
IL65801A (en) | 1985-09-29 |
IE53034B1 (en) | 1988-05-11 |
ES8401075A1 (es) | 1983-12-01 |
JPS57193485A (en) | 1982-11-27 |
PL236472A1 (en) | 1984-07-30 |
KR830010115A (ko) | 1983-12-26 |
PT74912A (en) | 1982-06-01 |
DE3265802D1 (en) | 1985-10-03 |
PH20072A (en) | 1986-09-18 |
NZ200631A (en) | 1985-10-11 |
FI821733A0 (fi) | 1982-05-17 |
ES521125A0 (es) | 1984-06-01 |
IE821179L (en) | 1982-11-18 |
BR8202861A (pt) | 1983-04-26 |
NO821616L (no) | 1982-11-19 |
PL246771A1 (en) | 1984-10-22 |
ES8404791A1 (es) | 1984-06-01 |
ES512275A0 (es) | 1983-12-01 |
HU186933B (en) | 1985-10-28 |
DK221882A (da) | 1982-11-19 |
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