ZA823414B - Anti-hypertensive 1-substituted spiro (piperidine-oxobenzoxazine)s - Google Patents

Anti-hypertensive 1-substituted spiro (piperidine-oxobenzoxazine)s

Info

Publication number
ZA823414B
ZA823414B ZA823414A ZA823414A ZA823414B ZA 823414 B ZA823414 B ZA 823414B ZA 823414 A ZA823414 A ZA 823414A ZA 823414 A ZA823414 A ZA 823414A ZA 823414 B ZA823414 B ZA 823414B
Authority
ZA
South Africa
Prior art keywords
omega
aryl
halo
lower alkyl
group
Prior art date
Application number
ZA823414A
Other languages
English (en)
Inventor
Adolph Peter Roszkowski
Robin Douglas Clark
Arthur Frederick Kluge
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA823414B publication Critical patent/ZA823414B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA823414A 1981-05-18 1982-05-17 Anti-hypertensive 1-substituted spiro (piperidine-oxobenzoxazine)s ZA823414B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/264,779 US4349549A (en) 1981-05-18 1981-05-18 Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s

Publications (1)

Publication Number Publication Date
ZA823414B true ZA823414B (en) 1983-12-28

Family

ID=23007572

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA823414A ZA823414B (en) 1981-05-18 1982-05-17 Anti-hypertensive 1-substituted spiro (piperidine-oxobenzoxazine)s

Country Status (20)

Country Link
US (1) US4349549A (de)
EP (1) EP0065864B1 (de)
JP (1) JPS57193485A (de)
KR (1) KR830010115A (de)
AT (1) ATE15198T1 (de)
AU (1) AU8376982A (de)
BR (1) BR8202861A (de)
DE (1) DE3265802D1 (de)
DK (1) DK221882A (de)
ES (3) ES512275A0 (de)
FI (1) FI821733A0 (de)
HU (1) HU186933B (de)
IE (1) IE53034B1 (de)
IL (1) IL65801A (de)
NO (1) NO821616L (de)
NZ (1) NZ200631A (de)
PH (1) PH20072A (de)
PL (2) PL236472A1 (de)
PT (1) PT74912B (de)
ZA (1) ZA823414B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815979A (ja) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体およびその製造法
JPS5959685A (ja) * 1982-09-28 1984-04-05 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
GB2131021B (en) * 1982-11-24 1985-12-18 Erba Farmitalia Antipsychotic benzoxazines
US4558049A (en) * 1982-11-24 1985-12-10 Farmitalia Carlo Erba S.P.A. Antipsycotic benzoxazines
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
SE9202218D0 (sv) * 1992-07-22 1992-07-22 Kabi Pharmacia Ab Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
AU2274101A (en) * 1999-12-21 2001-07-03 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU2001230537A1 (en) * 2000-02-01 2001-08-14 Daiichi Pharmaceutical Co., Ltd. Pyridoxazine derivatives
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
MX2007002033A (es) 2004-08-19 2007-04-26 Vertex Pharma Moduladores de receptores muscarinicos.
RU2007124373A (ru) * 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
JP2009521483A (ja) * 2005-12-22 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
AU2007221220A1 (en) * 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Spiro condensed piperidnes as modulators of muscarinic receptors
RU2008137593A (ru) * 2006-02-22 2010-03-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецепторов
EP2040706A2 (de) * 2006-06-29 2009-04-01 Vertex Pharmceuticals Incorporated Modulatoren muskarinischer rezeptoren
EP2051712A2 (de) * 2006-08-15 2009-04-29 Vertex Pharmceuticals Incorporated Modulatoren muskarinischer rezeptoren
JP2010501561A (ja) * 2006-08-18 2010-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
EP2207549A1 (de) * 2007-10-03 2010-07-21 Vertex Pharmceuticals Incorporated Modulatoren muskarinischer rezeptoren
CN113264949B (zh) * 2021-05-31 2022-04-05 西南大学 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA952908A (en) * 1970-02-27 1974-08-13 Yoshitomi Pharmaceutical Industries Benzodioxane derivatives
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments

Also Published As

Publication number Publication date
IL65801A (en) 1985-09-29
AU8376982A (en) 1982-11-25
PH20072A (en) 1986-09-18
BR8202861A (pt) 1983-04-26
EP0065864A1 (de) 1982-12-01
ES8404790A1 (es) 1984-06-01
PL246771A1 (en) 1984-10-22
FI821733A0 (fi) 1982-05-17
KR830010115A (ko) 1983-12-26
IL65801A0 (en) 1982-08-31
PT74912A (en) 1982-06-01
EP0065864B1 (de) 1985-08-28
ATE15198T1 (de) 1985-09-15
PT74912B (en) 1983-12-07
HU186933B (en) 1985-10-28
DK221882A (da) 1982-11-19
US4349549A (en) 1982-09-14
NO821616L (no) 1982-11-19
PL236472A1 (en) 1984-07-30
ES8404791A1 (es) 1984-06-01
IE821179L (en) 1982-11-18
JPS57193485A (en) 1982-11-27
NZ200631A (en) 1985-10-11
ES521125A0 (es) 1984-06-01
IE53034B1 (en) 1988-05-11
ES521124A0 (es) 1984-06-01
DE3265802D1 (en) 1985-10-03
ES8401075A1 (es) 1983-12-01
ES512275A0 (es) 1983-12-01

Similar Documents

Publication Publication Date Title
DE3265802D1 (en) Anti-hypertensive 1-substituted spiro (piperidine-oxobenzoxazines)
IE832405L (en) 1-phenyl-2-piperidinoalkanols.
ES8304944A1 (es) Un procedimiento para la preparacion de derivados de aminopirimidina.
IE780145L (en) Meta-sulphonamido-benzamides
ES8207525A1 (es) Un procedimiento para la preparacion de nuevos derivados de la quinoleina.
AU7810787A (en) 6-{2-(3-phenoxy-2-hydroxy-propylamino)-propyl-amino}-5- methyl-pyrizine-3-one derivatives useful as antihyper- tensive agents
MY103502A (en) Novel compounds
AU546260B2 (en) Diphenylbutyl-1-acylpiperazines
IE820239L (en) Carbapenem derivatives
SE8901060D0 (sv) New compounds
ES8201979A1 (es) Procedimiento para la obtencion de derivados de bifeni- lil-azoliletano
IE811212L (en) Substituted phenoxy-aminopropanol derivatives
AU551901B2 (en) Substituted thienobenzodiazepinones
IE801382L (en) Piperidines.
GB2017080A (en) Benzothiazepines
ES8106144A1 (es) Procedimiento para la preparacion de derivados de aroilete- nilpiperidinobutirofenona
DE3362036D1 (en) Ketene-o,o-acetates and process for their preparation
ES8106143A1 (es) Procedimiento para la preparacion de derivados de cinamoil- piperidinobutirofenona
HUT44502A (en) Process for producing 3-amino-dihydropyridine derivatives and pharmaceutical compositions containing them