ES8404791A1 - Procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas. - Google Patents

Procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas.

Info

Publication number
ES8404791A1
ES8404791A1 ES521125A ES521125A ES8404791A1 ES 8404791 A1 ES8404791 A1 ES 8404791A1 ES 521125 A ES521125 A ES 521125A ES 521125 A ES521125 A ES 521125A ES 8404791 A1 ES8404791 A1 ES 8404791A1
Authority
ES
Spain
Prior art keywords
omega
aryl
halo
lower alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521125A
Other languages
English (en)
Other versions
ES521125A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES521125A0 publication Critical patent/ES521125A0/es
Publication of ES8404791A1 publication Critical patent/ES8404791A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ESPIRO (PIPERIDINO-OXOBENZOXA ZINAS) SUSTITUIDAS EN POSICION 1 ANTIHIPERTENSIVAS.CONSIS TE EN: A) TRATAR UN COMPUESTO DE FORMULA (II) CON UNA BASE FUERTE PARA OBTENER COM1M PUESTOS DE FORMULA (I) Y SUS SALES POR ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES TALES COMO CLORHIDRICO, BROMHIDRICO, SULFURICO, NITRICO, FOSFORICO, ACETICO, PROPIONICO, GLICOLICO, PIRUVICO, OXALICO Y OTROS, EN PRESENCIA DE UN DISOLVENTE ORGANICO TAL COMO ALCOHOL, DONDE R1, R2, R3 Y R4 SON, CADA UNO DE ELLOS INDEPENDIENTEMENTE HIDROGENO, HIDROXI, ALCOHILO INFERIOR, ALCOXI INFERIOR O HALO; R ES HIDROGENOO ALCOHILO INFERIOR; Y A ES 2-(BENZODIOXAN-2-IL)-2-HIDROX IETILO.POSEE APLICACIONES FARMACOLOGICAS POR SU EFICACIA SOBRE EL SISTEMA NERVIOSO CENTRAL Y POR SER UTILES PARA TRATAR LA HIPERTENSION.
ES521125A 1981-05-18 1983-03-30 Procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas. Expired ES8404791A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/264,779 US4349549A (en) 1981-05-18 1981-05-18 Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s

Publications (2)

Publication Number Publication Date
ES521125A0 ES521125A0 (es) 1984-06-01
ES8404791A1 true ES8404791A1 (es) 1984-06-01

Family

ID=23007572

Family Applications (3)

Application Number Title Priority Date Filing Date
ES512275A Expired ES8401075A1 (es) 1981-05-18 1982-05-17 "procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas".
ES521124A Expired ES8404790A1 (es) 1981-05-18 1983-03-30 Procedimiento para preparar espino (piperidino-oxobenzo-xazinas) substituidas en posicion 1 anti-hipertensivas.
ES521125A Expired ES8404791A1 (es) 1981-05-18 1983-03-30 Procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES512275A Expired ES8401075A1 (es) 1981-05-18 1982-05-17 "procedimiento para preparar espiro (piperidino-oxobenzoxazinas) substituidas en posicion 1 anti-hipertensivas".
ES521124A Expired ES8404790A1 (es) 1981-05-18 1983-03-30 Procedimiento para preparar espino (piperidino-oxobenzo-xazinas) substituidas en posicion 1 anti-hipertensivas.

Country Status (20)

Country Link
US (1) US4349549A (es)
EP (1) EP0065864B1 (es)
JP (1) JPS57193485A (es)
KR (1) KR830010115A (es)
AT (1) ATE15198T1 (es)
AU (1) AU8376982A (es)
BR (1) BR8202861A (es)
DE (1) DE3265802D1 (es)
DK (1) DK221882A (es)
ES (3) ES8401075A1 (es)
FI (1) FI821733A0 (es)
HU (1) HU186933B (es)
IE (1) IE53034B1 (es)
IL (1) IL65801A (es)
NO (1) NO821616L (es)
NZ (1) NZ200631A (es)
PH (1) PH20072A (es)
PL (2) PL246771A1 (es)
PT (1) PT74912B (es)
ZA (1) ZA823414B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815979A (ja) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体およびその製造法
JPS5959685A (ja) * 1982-09-28 1984-04-05 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
US4558049A (en) * 1982-11-24 1985-12-10 Farmitalia Carlo Erba S.P.A. Antipsycotic benzoxazines
GB2131021B (en) * 1982-11-24 1985-12-18 Erba Farmitalia Antipsychotic benzoxazines
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
SE9202218D0 (sv) * 1992-07-22 1992-07-22 Kabi Pharmacia Ab Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
AU2274101A (en) * 1999-12-21 2001-07-03 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU2001230537A1 (en) * 2000-02-01 2001-08-14 Daiichi Pharmaceutical Co., Ltd. Pyridoxazine derivatives
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
RU2007109794A (ru) * 2004-08-19 2008-09-27 Вертекс Фармасьютикалз, Инкорпорейтед (Us) Модуляторы мускариновых рецепторов
AU2005309365B2 (en) * 2004-11-29 2011-10-06 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
AU2006330866A1 (en) * 2005-12-22 2007-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
ATE517106T1 (de) * 2006-02-22 2011-08-15 Vertex Pharma Kondensierte spiropiperidine als modulatoren muskarinartiger rezeptoren
EP1988892A2 (en) 2006-02-22 2008-11-12 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
CN101553231A (zh) * 2006-08-15 2009-10-07 弗特克斯药品有限公司 毒蕈碱受体调节剂
JP2010501561A (ja) * 2006-08-18 2010-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
CA2700724A1 (en) * 2007-10-03 2009-04-09 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CN113264949B (zh) * 2021-05-31 2022-04-05 西南大学 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA952908A (en) * 1970-02-27 1974-08-13 Yoshitomi Pharmaceutical Industries Benzodioxane derivatives
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments

Also Published As

Publication number Publication date
ES521124A0 (es) 1984-06-01
KR830010115A (ko) 1983-12-26
ES521125A0 (es) 1984-06-01
EP0065864B1 (en) 1985-08-28
DE3265802D1 (en) 1985-10-03
AU8376982A (en) 1982-11-25
IE821179L (en) 1982-11-18
IE53034B1 (en) 1988-05-11
PL246771A1 (en) 1984-10-22
US4349549A (en) 1982-09-14
ES512275A0 (es) 1983-12-01
FI821733A0 (fi) 1982-05-17
BR8202861A (pt) 1983-04-26
HU186933B (en) 1985-10-28
PT74912B (en) 1983-12-07
IL65801A (en) 1985-09-29
DK221882A (da) 1982-11-19
ATE15198T1 (de) 1985-09-15
PH20072A (en) 1986-09-18
NZ200631A (en) 1985-10-11
IL65801A0 (en) 1982-08-31
ES8401075A1 (es) 1983-12-01
EP0065864A1 (en) 1982-12-01
PT74912A (en) 1982-06-01
ZA823414B (en) 1983-12-28
JPS57193485A (en) 1982-11-27
PL236472A1 (en) 1984-07-30
NO821616L (no) 1982-11-19
ES8404790A1 (es) 1984-06-01

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