PT74912B - Process for preparing anti-hypertensive 1-substituted siro <piperidine-oxobenzoxazine>s - Google Patents
Process for preparing anti-hypertensive 1-substituted siro <piperidine-oxobenzoxazine>sInfo
- Publication number
- PT74912B PT74912B PT74912A PT7491282A PT74912B PT 74912 B PT74912 B PT 74912B PT 74912 A PT74912 A PT 74912A PT 7491282 A PT7491282 A PT 7491282A PT 74912 B PT74912 B PT 74912B
- Authority
- PT
- Portugal
- Prior art keywords
- omega
- aryl
- halo
- lower alkyl
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/264,779 US4349549A (en) | 1981-05-18 | 1981-05-18 | Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT74912A PT74912A (en) | 1982-06-01 |
| PT74912B true PT74912B (en) | 1983-12-07 |
Family
ID=23007572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT74912A PT74912B (en) | 1981-05-18 | 1982-05-17 | Process for preparing anti-hypertensive 1-substituted siro <piperidine-oxobenzoxazine>s |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4349549A (pt) |
| EP (1) | EP0065864B1 (pt) |
| JP (1) | JPS57193485A (pt) |
| KR (1) | KR830010115A (pt) |
| AT (1) | ATE15198T1 (pt) |
| AU (1) | AU8376982A (pt) |
| BR (1) | BR8202861A (pt) |
| DE (1) | DE3265802D1 (pt) |
| DK (1) | DK221882A (pt) |
| ES (3) | ES512275A0 (pt) |
| FI (1) | FI821733A0 (pt) |
| HU (1) | HU186933B (pt) |
| IE (1) | IE53034B1 (pt) |
| IL (1) | IL65801A (pt) |
| NO (1) | NO821616L (pt) |
| NZ (1) | NZ200631A (pt) |
| PH (1) | PH20072A (pt) |
| PL (2) | PL236472A1 (pt) |
| PT (1) | PT74912B (pt) |
| ZA (1) | ZA823414B (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815979A (ja) * | 1981-07-11 | 1983-01-29 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体およびその製造法 |
| JPS5959685A (ja) * | 1982-09-28 | 1984-04-05 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| GB2131021B (en) * | 1982-11-24 | 1985-12-18 | Erba Farmitalia | Antipsychotic benzoxazines |
| US4558049A (en) * | 1982-11-24 | 1985-12-10 | Farmitalia Carlo Erba S.P.A. | Antipsycotic benzoxazines |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| SE9202218D0 (sv) * | 1992-07-22 | 1992-07-22 | Kabi Pharmacia Ab | Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation |
| US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
| AU2274101A (en) * | 1999-12-21 | 2001-07-03 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| AU2001230537A1 (en) * | 2000-02-01 | 2001-08-14 | Daiichi Pharmaceutical Co., Ltd. | Pyridoxazine derivatives |
| US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
| MX2007002033A (es) | 2004-08-19 | 2007-04-26 | Vertex Pharma | Moduladores de receptores muscarinicos. |
| RU2007124373A (ru) * | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
| JP2009521483A (ja) * | 2005-12-22 | 2009-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| US7351706B2 (en) * | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
| AU2007221220A1 (en) * | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Spiro condensed piperidnes as modulators of muscarinic receptors |
| RU2008137593A (ru) * | 2006-02-22 | 2010-03-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
| EP2040706A2 (en) * | 2006-06-29 | 2009-04-01 | Vertex Pharmceuticals Incorporated | Modulators of muscarinic receptors |
| EP2051712A2 (en) * | 2006-08-15 | 2009-04-29 | Vertex Pharmceuticals Incorporated | Modulators of muscarinic receptors |
| JP2010501561A (ja) * | 2006-08-18 | 2010-01-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
| EP2207549A1 (en) * | 2007-10-03 | 2010-07-21 | Vertex Pharmceuticals Incorporated | Modulators of muscarinic receptors |
| CN113264949B (zh) * | 2021-05-31 | 2022-04-05 | 西南大学 | 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA952908A (en) * | 1970-02-27 | 1974-08-13 | Yoshitomi Pharmaceutical Industries | Benzodioxane derivatives |
| FR2420536A1 (fr) * | 1978-03-22 | 1979-10-19 | Roussel Uclaf | Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments |
-
1981
- 1981-05-18 US US06/264,779 patent/US4349549A/en not_active Expired - Fee Related
-
1982
- 1982-05-14 NO NO821616A patent/NO821616L/no unknown
- 1982-05-14 PH PH27300A patent/PH20072A/en unknown
- 1982-05-17 AT AT82302494T patent/ATE15198T1/de active
- 1982-05-17 FI FI821733A patent/FI821733A0/fi not_active Application Discontinuation
- 1982-05-17 PL PL23647282A patent/PL236472A1/xx unknown
- 1982-05-17 ZA ZA823414A patent/ZA823414B/xx unknown
- 1982-05-17 DE DE8282302494T patent/DE3265802D1/de not_active Expired
- 1982-05-17 PT PT74912A patent/PT74912B/pt unknown
- 1982-05-17 PL PL24677182A patent/PL246771A1/xx unknown
- 1982-05-17 HU HU821547A patent/HU186933B/hu unknown
- 1982-05-17 JP JP57081739A patent/JPS57193485A/ja active Pending
- 1982-05-17 BR BR8202861A patent/BR8202861A/pt unknown
- 1982-05-17 IE IE1179/82A patent/IE53034B1/en unknown
- 1982-05-17 AU AU83769/82A patent/AU8376982A/en not_active Abandoned
- 1982-05-17 IL IL65801A patent/IL65801A/xx unknown
- 1982-05-17 NZ NZ200631A patent/NZ200631A/en unknown
- 1982-05-17 EP EP82302494A patent/EP0065864B1/en not_active Expired
- 1982-05-17 ES ES512275A patent/ES512275A0/es active Granted
- 1982-05-17 KR KR1019820002137A patent/KR830010115A/ko unknown
- 1982-05-17 DK DK221882A patent/DK221882A/da not_active Application Discontinuation
-
1983
- 1983-03-30 ES ES521124A patent/ES521124A0/es active Granted
- 1983-03-30 ES ES521125A patent/ES521125A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IL65801A (en) | 1985-09-29 |
| AU8376982A (en) | 1982-11-25 |
| PH20072A (en) | 1986-09-18 |
| BR8202861A (pt) | 1983-04-26 |
| EP0065864A1 (en) | 1982-12-01 |
| ES8404790A1 (es) | 1984-06-01 |
| PL246771A1 (en) | 1984-10-22 |
| FI821733A0 (fi) | 1982-05-17 |
| ZA823414B (en) | 1983-12-28 |
| KR830010115A (ko) | 1983-12-26 |
| IL65801A0 (en) | 1982-08-31 |
| PT74912A (en) | 1982-06-01 |
| EP0065864B1 (en) | 1985-08-28 |
| ATE15198T1 (de) | 1985-09-15 |
| HU186933B (en) | 1985-10-28 |
| DK221882A (da) | 1982-11-19 |
| US4349549A (en) | 1982-09-14 |
| NO821616L (no) | 1982-11-19 |
| PL236472A1 (en) | 1984-07-30 |
| ES8404791A1 (es) | 1984-06-01 |
| IE821179L (en) | 1982-11-18 |
| JPS57193485A (en) | 1982-11-27 |
| NZ200631A (en) | 1985-10-11 |
| ES521125A0 (es) | 1984-06-01 |
| IE53034B1 (en) | 1988-05-11 |
| ES521124A0 (es) | 1984-06-01 |
| DE3265802D1 (en) | 1985-10-03 |
| ES8401075A1 (es) | 1983-12-01 |
| ES512275A0 (es) | 1983-12-01 |
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