UA26852C2 - Спосіб одержаhhя похідhих 1-беhзил-3-оксиметиліhдазолу або їх солей з фармацевтичhо прийhятhими осhовами - Google Patents

Спосіб одержаhhя похідhих 1-беhзил-3-оксиметиліhдазолу або їх солей з фармацевтичhо прийhятhими осhовами

Info

Publication number
UA26852C2
UA26852C2 UA4743128A UA4743128A UA26852C2 UA 26852 C2 UA26852 C2 UA 26852C2 UA 4743128 A UA4743128 A UA 4743128A UA 4743128 A UA4743128 A UA 4743128A UA 26852 C2 UA26852 C2 UA 26852C2
Authority
UA
Ukraine
Prior art keywords
salts
bezyl
oxymethyl
diazole
obtaining derivatives
Prior art date
Application number
UA4743128A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Бруно СІЛВЕСТРІHІ
Леандро Байоккі
Original Assignee
Ацьєhде Кіміке Рьюhіті Аhджеліhі Фраhческо А.К.Р.А.Ф.С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьєhде Кіміке Рьюhіті Аhджеліhі Фраhческо А.К.Р.А.Ф.С.П.А. filed Critical Ацьєhде Кіміке Рьюhіті Аhджеліhі Фраhческо А.К.Р.А.Ф.С.П.А.
Publication of UA26852C2 publication Critical patent/UA26852C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
UA4743128A 1989-02-07 1990-02-06 Спосіб одержаhhя похідhих 1-беhзил-3-оксиметиліhдазолу або їх солей з фармацевтичhо прийhятhими осhовами UA26852C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8947620A IT1230441B (it) 1989-02-07 1989-02-07 Eteri della serie dell'indazolo

Publications (1)

Publication Number Publication Date
UA26852C2 true UA26852C2 (uk) 1999-12-29

Family

ID=11261479

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4743128A UA26852C2 (uk) 1989-02-07 1990-02-06 Спосіб одержаhhя похідhих 1-беhзил-3-оксиметиліhдазолу або їх солей з фармацевтичhо прийhятhими осhовами

Country Status (36)

Country Link
US (2) US4999367A (en:Method)
EP (1) EP0382276B1 (en:Method)
JP (1) JP2870925B2 (en:Method)
KR (1) KR0145525B1 (en:Method)
CN (2) CN1046505C (en:Method)
AR (1) AR247386A1 (en:Method)
AT (1) ATE127115T1 (en:Method)
AU (1) AU624895B2 (en:Method)
BG (1) BG50273A3 (en:Method)
CA (1) CA2009503C (en:Method)
CZ (1) CZ280121B6 (en:Method)
DD (2) DD291995A5 (en:Method)
DE (2) DE382276T1 (en:Method)
DK (1) DK0382276T3 (en:Method)
EG (1) EG19170A (en:Method)
ES (1) ES2020171T3 (en:Method)
FI (1) FI102678B (en:Method)
GE (1) GEP19971030B (en:Method)
GR (2) GR910300073T1 (en:Method)
HU (1) HU204793B (en:Method)
IL (1) IL93132A (en:Method)
IN (1) IN170957B (en:Method)
IT (1) IT1230441B (en:Method)
LT (1) LT3604B (en:Method)
LV (1) LV10612B (en:Method)
NZ (1) NZ232258A (en:Method)
PE (1) PE25091A1 (en:Method)
PH (1) PH26552A (en:Method)
PL (2) PL163720B1 (en:Method)
PT (1) PT93067B (en:Method)
RO (1) RO106252B1 (en:Method)
RU (3) RU2066318C1 (en:Method)
SK (1) SK278441B6 (en:Method)
UA (1) UA26852C2 (en:Method)
YU (1) YU47943B (en:Method)
ZA (1) ZA90644B (en:Method)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253703B (it) * 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) * 1997-11-26 1999-08-24 Intel Corporation Two-transistor DRAM cell for logic process technology
US7514463B2 (en) * 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
EP2254869B1 (en) 2008-03-07 2017-05-31 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. Neue 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of cx3cr1 und p40
MX2010009624A (es) 2008-03-07 2010-09-28 Acraf Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1.
SI2262778T1 (sl) 2008-03-07 2019-12-31 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzil-3-hidroksimetilindazolni derivati in njihova uporaba pri zdravljenju bolezni, na osnovi izražanja MCP-1, CXCR1 in P40
SI2462119T1 (sl) * 2009-08-03 2014-10-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Postopek za pripravo 1-benzil-3-hidroksimetil-1H-indazola in njegovih derivatov ter potrebni magnezijevi intermediati
UA108742C2 (uk) * 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
CN104334173B (zh) 2012-05-01 2017-05-03 特兰斯拉图姆医学公司 用于治疗和诊断致盲性眼病的方法
WO2013171316A1 (en) 2012-05-18 2013-11-21 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
LT2882715T (lt) 2012-05-18 2017-02-10 Sanofi Pirazolo dariniai ir jų panaudojimas kaip lpar5 antagonistų
CN108047136B (zh) * 2017-12-20 2021-07-09 长春普华制药股份有限公司 一种苄达酸的精制方法
CA3144861A1 (en) * 2019-06-25 2020-12-30 Translatum Medicus, Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28032A (en) * 1966-08-29 1971-08-25 Acraf Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it) 1980-07-29 1986-06-25 Acraf Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it) 1981-11-27 1988-01-28 Acraf Trattamento della cataratta
IT1194564B (it) 1983-04-18 1988-09-22 Acraf Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it) 1986-08-01 1988-12-06 Acraf Metodo per il tratamento di lenti a contatto

Also Published As

Publication number Publication date
LTIP872A (en) 1995-03-27
RU2055071C1 (ru) 1996-02-27
PE25091A1 (es) 1991-08-17
ES2020171T3 (es) 1995-12-01
PH26552A (en) 1992-08-19
FI900577A0 (fi) 1990-02-06
PL163730B1 (pl) 1994-04-29
ATE127115T1 (de) 1995-09-15
AU4906690A (en) 1990-08-16
IT1230441B (it) 1991-10-23
YU47943B (sh) 1996-07-24
CA2009503A1 (en) 1990-08-07
IL93132A0 (en) 1990-11-05
CZ56390A3 (en) 1995-06-14
DD295363A5 (de) 1991-10-31
IT8947620A0 (it) 1989-02-07
CA2009503C (en) 2000-04-11
KR900012913A (ko) 1990-09-03
IL93132A (en) 1994-05-30
LV10612A (lv) 1995-04-20
RO106252B1 (ro) 1993-03-31
KR0145525B1 (ko) 1998-08-17
RU2044729C1 (ru) 1995-09-27
HUT53088A (en) 1990-09-28
CN1088201A (zh) 1994-06-22
SK56390A3 (en) 1997-05-07
DK0382276T3 (da) 1996-01-15
CZ280121B6 (cs) 1995-11-15
US5112986A (en) 1992-05-12
IN170957B (en:Method) 1992-06-20
CN1034016C (zh) 1997-02-12
BG50273A3 (en) 1992-06-15
DD291995A5 (de) 1991-07-18
EG19170A (en) 1994-11-30
JPH02240065A (ja) 1990-09-25
GR910300073T1 (en) 1991-11-15
EP0382276A2 (en) 1990-08-16
PL163720B1 (pl) 1994-04-29
EP0382276B1 (en) 1995-08-30
CN1046505C (zh) 1999-11-17
RU2066318C1 (ru) 1996-09-10
HU204793B (en) 1992-02-28
FI102678B1 (fi) 1999-01-29
SK278441B6 (en) 1997-05-07
EP0382276A3 (en) 1990-12-12
JP2870925B2 (ja) 1999-03-17
YU20690A (sh) 1992-07-20
HU900689D0 (en) 1990-04-28
GR3018165T3 (en) 1996-02-29
LT3604B (en) 1995-12-27
LV10612B (en) 1995-08-20
AR247386A1 (es) 1994-12-29
PT93067B (pt) 1995-12-29
GEP19971030B (en) 1997-06-13
NZ232258A (en) 1991-06-25
ZA90644B (en) 1991-01-30
FI102678B (fi) 1999-01-29
DE69021902T2 (de) 1996-05-23
ES2020171A4 (es) 1991-08-01
US4999367A (en) 1991-03-12
DE382276T1 (de) 1991-11-28
PT93067A (pt) 1990-08-31
AU624895B2 (en) 1992-06-25
CN1044810A (zh) 1990-08-22
DE69021902D1 (de) 1995-10-05

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