UA19169A - Спосіб одержаhhя порошку ліофілізоваhого аhтрацикліh глікозиду - Google Patents

Спосіб одержаhhя порошку ліофілізоваhого аhтрацикліh глікозиду

Info

Publication number
UA19169A
UA19169A UA3964940A UA3964940A UA19169A UA 19169 A UA19169 A UA 19169A UA 3964940 A UA3964940 A UA 3964940A UA 3964940 A UA3964940 A UA 3964940A UA 19169 A UA19169 A UA 19169A
Authority
UA
Ukraine
Prior art keywords
dried powder
anthracycline glycoside
freeze
producing freeze
producing
Prior art date
Application number
UA3964940A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Гатті Гаетано
Олдані Дієго
Конфалонієрі Карло
Гамбіні Лучано
Original Assignee
Фарміталіа Карло Ерба С.Р.Л.
Фармиталиа Карло Эрба С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фарміталіа Карло Ерба С.Р.Л., Фармиталиа Карло Эрба С.Р.Л. filed Critical Фарміталіа Карло Ерба С.Р.Л.
Publication of UA19169A publication Critical patent/UA19169A/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA3964940A 1984-10-22 1985-10-18 Спосіб одержаhhя порошку ліофілізоваhого аhтрацикліh глікозиду UA19169A (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
UA19169A true UA19169A (uk) 1997-12-25

Family

ID=10568553

Family Applications (2)

Application Number Title Priority Date Filing Date
UA3964940A UA19169A (uk) 1984-10-22 1985-10-18 Спосіб одержаhhя порошку ліофілізоваhого аhтрацикліh глікозиду
UA5010680A UA34419C2 (uk) 1984-10-22 1985-10-18 Ліофілізований препарат для ін'єкцій та спосіб інгібування росту пухлин

Family Applications After (1)

Application Number Title Priority Date Filing Date
UA5010680A UA34419C2 (uk) 1984-10-22 1985-10-18 Ліофілізований препарат для ін'єкцій та спосіб інгібування росту пухлин

Country Status (35)

Country Link
US (4) US4675311A (enEXAMPLES)
JP (1) JPH0611700B2 (enEXAMPLES)
KR (1) KR920005813B1 (enEXAMPLES)
CN (1) CN85107562B (enEXAMPLES)
AT (1) AT401345B (enEXAMPLES)
AU (1) AU572003B2 (enEXAMPLES)
BE (1) BE903484A (enEXAMPLES)
BG (1) BG60934B2 (enEXAMPLES)
CA (1) CA1248453A (enEXAMPLES)
CH (1) CH667594A5 (enEXAMPLES)
CS (1) CS270421B2 (enEXAMPLES)
DE (1) DE3536896C2 (enEXAMPLES)
DK (1) DK165620C (enEXAMPLES)
ES (1) ES8605374A1 (enEXAMPLES)
FI (2) FI853913A7 (enEXAMPLES)
FR (1) FR2571966B1 (enEXAMPLES)
GB (2) GB8426672D0 (enEXAMPLES)
GR (1) GR852549B (enEXAMPLES)
HK (1) HK94390A (enEXAMPLES)
HU (1) HU197988B (enEXAMPLES)
IE (1) IE56992B1 (enEXAMPLES)
IL (1) IL76732A (enEXAMPLES)
IT (1) IT1186779B (enEXAMPLES)
MY (1) MY103956A (enEXAMPLES)
NL (1) NL191308C (enEXAMPLES)
NO (1) NO170616C (enEXAMPLES)
NZ (1) NZ213885A (enEXAMPLES)
PH (1) PH23982A (enEXAMPLES)
PT (1) PT81347B (enEXAMPLES)
RU (2) RU1836088C (enEXAMPLES)
SE (1) SE467520B (enEXAMPLES)
SG (1) SG80290G (enEXAMPLES)
UA (2) UA19169A (enEXAMPLES)
YU (1) YU46160B (enEXAMPLES)
ZA (1) ZA858033B (enEXAMPLES)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
CH680494A5 (enEXAMPLES) * 1986-12-05 1992-09-15 Erba Carlo Spa
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
CA2275889C (en) 1996-12-30 2008-03-18 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
PL205936B1 (pl) 2002-02-22 2010-06-30 Schering Corp Farmaceutyczny preparat zawierający termozolomid oraz sposób jego wytwarzania
DK1474995T3 (da) * 2003-05-06 2013-02-18 Gumlink As Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
WO2005030239A2 (en) * 2003-09-25 2005-04-07 Astellas Pharma Inc. Antitumor agent comprising a histone deacetylase inhibitor and a topoisomerase ii inhibitor
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
JP2008513519A (ja) * 2005-05-11 2008-05-01 シコール インコーポレイティド 安定した凍結乾燥されたアントラサイクリングリコシド
JP4778053B2 (ja) 2005-07-14 2011-09-21 リセラ，インコーポレイテッド 局所的脂肪組織処置のための徐放性増強脂肪分解処方物
RU2450013C2 (ru) * 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CN101743020A (zh) * 2007-05-16 2010-06-16 Ktb肿瘤研究有限责任公司 低粘度蒽环制剂
CN101795694B (zh) 2007-09-04 2012-10-10 明治制果药业株式会社 注射剂、注射液和注射用试剂盒制剂
MX2010004457A (es) * 2007-10-26 2010-05-03 Pfizer Prod Inc Idarubicina para el tratamiento de linfoma en un perro.
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
MX2012008171A (es) * 2010-01-15 2012-12-17 Lithera Inc Formulaciones aglomeradas liofilizadas.
US9597531B2 (en) 2010-11-24 2017-03-21 Neothetics, Inc. Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
JP6433913B2 (ja) 2012-12-13 2018-12-05 サイトレックス コーポレイション アントラサイクリン製剤
CA2912908C (en) 2013-06-05 2021-06-08 Cytrx Corporation Cytotoxic agents comprising covalently protein binding groups for treating brain cancer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
JPS563851A (en) * 1979-06-22 1981-01-16 Matsushita Electric Works Ltd Fireplace in floor
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
GR79729B (enEXAMPLES) * 1982-12-20 1984-10-31 Univ Ohio State Res Found
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same

Also Published As

Publication number Publication date
CN85107562B (zh) 1988-06-01
FI86252B (fi) 1992-04-30
NO170616B (no) 1992-08-03
UA34419C2 (uk) 2001-03-15
RU2101018C1 (ru) 1998-01-10
DK165620C (da) 1993-06-01
ZA858033B (en) 1986-06-25
NL191308B (nl) 1994-12-16
JPS61246129A (ja) 1986-11-01
US4675311A (en) 1987-06-23
PT81347A (en) 1985-11-01
IE852593L (en) 1986-04-22
CN85107562A (zh) 1986-07-23
US5091373A (en) 1992-02-25
FI854035A0 (fi) 1985-10-16
BE903484A (fr) 1986-04-21
NO854194L (no) 1986-04-23
FR2571966B1 (fr) 1988-04-15
HU197988B (en) 1989-07-28
PH23982A (en) 1990-02-09
CS270421B2 (en) 1990-06-13
US5091372A (en) 1992-02-25
DE3536896C2 (de) 1996-11-14
FI854035L (fi) 1986-04-23
DK165620B (da) 1992-12-28
GB2165751B (en) 1988-08-17
ES547578A0 (es) 1986-03-16
SG80290G (en) 1990-11-23
GR852549B (enEXAMPLES) 1986-02-24
DK481585A (da) 1986-04-23
FR2571966A1 (fr) 1986-04-25
HK94390A (en) 1990-11-23
SE8504945D0 (sv) 1985-10-21
CA1248453A (en) 1989-01-10
US4840938A (en) 1989-06-20
NL8502869A (nl) 1986-05-16
GB8426672D0 (en) 1984-11-28
GB2165751A (en) 1986-04-23
AT401345B (de) 1996-08-26
CH667594A5 (de) 1988-10-31
FI86252C (fi) 1992-08-10
AU572003B2 (en) 1988-04-28
BG60934B2 (bg) 1996-06-28
NL191308C (nl) 1995-05-16
PT81347B (pt) 1987-11-11
HUT40759A (en) 1987-02-27
DK481585D0 (da) 1985-10-21
AU4880585A (en) 1986-05-01
IL76732A (en) 1989-07-31
SE467520B (sv) 1992-08-03
NO170616C (no) 1992-11-11
FI853913A7 (fi) 1986-04-23
IE56992B1 (en) 1992-02-26
NZ213885A (en) 1988-05-30
RU1836088C (ru) 1993-08-23
IT1186779B (it) 1987-12-16
IL76732A0 (en) 1986-02-28
FI853913A0 (fi) 1985-10-08
KR920005813B1 (ko) 1992-07-20
SE8504945L (sv) 1986-04-23
JPH0611700B2 (ja) 1994-02-16
DE3536896A1 (de) 1986-04-24
KR860003014A (ko) 1986-05-19
ES8605374A1 (es) 1986-03-16
MY103956A (en) 1993-10-30
GB8525709D0 (en) 1985-11-20
YU46160B (sh) 1993-05-28
IT8522507A0 (it) 1985-10-16
CS756585A2 (en) 1989-11-14
ATA303285A (de) 1996-01-15
YU164485A (en) 1987-10-31

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