UA115145C2 - КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ АЗОТОВМІСНІ 5-ЧЛЕННІ ГЕТЕРОЦИКЛИ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ - Google Patents
КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ АЗОТОВМІСНІ 5-ЧЛЕННІ ГЕТЕРОЦИКЛИ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγInfo
- Publication number
- UA115145C2 UA115145C2 UAA201501989A UAA201501989A UA115145C2 UA 115145 C2 UA115145 C2 UA 115145C2 UA A201501989 A UAA201501989 A UA A201501989A UA A201501989 A UAA201501989 A UA A201501989A UA 115145 C2 UA115145 C2 UA 115145C2
- Authority
- UA
- Ukraine
- Prior art keywords
- modulators
- nuclear receptor
- carboxamide
- orphan nuclear
- substituted nitrogen
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Plural Heterocyclic Compounds (AREA)
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- Hydrogenated Pyridines (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
Винахід забезпечує модулятори орфанового ядерного рецептора ROR( та способи лікування захворювань, опосередкованих ROR(, шляхом введення цих нових модуляторів ROR( людині або ссавцеві, що цього потребує. Зокрема, цей винахід забезпечує карбоксамідвмісні циклічні сполуки формул (1)-(5): EMBED ISISServer , EMBED ISISServer , EMBED ISISServer , EMBED ISISServer , EMBED ISISServer , та їх енантіомери, діастереомери, таутомери, N-оксиди, сольвати та фармацевтично прийнятні солі.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261681296P | 2012-08-09 | 2012-08-09 | |
EP12005789 | 2012-08-09 | ||
PCT/EP2013/001594 WO2014023367A1 (en) | 2012-08-09 | 2013-05-29 | Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor ror gamma |
Publications (1)
Publication Number | Publication Date |
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UA115145C2 true UA115145C2 (uk) | 2017-09-25 |
Family
ID=46754230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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UAA201501989A UA115145C2 (uk) | 2012-08-09 | 2013-05-29 | КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ АЗОТОВМІСНІ 5-ЧЛЕННІ ГЕТЕРОЦИКЛИ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
Country Status (28)
Country | Link |
---|---|
US (1) | US9458104B2 (uk) |
EP (2) | EP3118189A1 (uk) |
JP (1) | JP6097829B2 (uk) |
KR (1) | KR101732973B1 (uk) |
CN (1) | CN104603105B (uk) |
AR (1) | AR091193A1 (uk) |
AU (1) | AU2013301914B2 (uk) |
BR (1) | BR112015002738A2 (uk) |
CA (1) | CA2879478C (uk) |
CL (1) | CL2015000300A1 (uk) |
CO (1) | CO7310529A2 (uk) |
EA (1) | EA027953B9 (uk) |
GT (1) | GT201500024A (uk) |
HK (1) | HK1211584A1 (uk) |
IL (1) | IL236695A (uk) |
IN (1) | IN2015DN01815A (uk) |
JO (1) | JO3215B1 (uk) |
MX (1) | MX364453B (uk) |
NO (1) | NO344067B1 (uk) |
NZ (1) | NZ704512A (uk) |
PE (1) | PE20150463A1 (uk) |
PH (1) | PH12015500142B1 (uk) |
SG (1) | SG11201500955RA (uk) |
TW (2) | TWI488839B (uk) |
UA (1) | UA115145C2 (uk) |
UY (1) | UY34833A (uk) |
WO (1) | WO2014023367A1 (uk) |
ZA (1) | ZA201500534B (uk) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI659019B (zh) | 2014-02-28 | 2019-05-11 | 日商帝人製藥股份有限公司 | 吡唑醯胺衍生物 |
JP6522665B2 (ja) * | 2014-05-28 | 2019-05-29 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 新規化合物 |
CA2949559C (en) | 2014-06-06 | 2023-08-29 | Research Triangle Institute | Apelin receptor (apj) agonists and uses thereof |
US9861618B2 (en) | 2014-10-30 | 2018-01-09 | Janssen Pharmaceutica Nv | Thiazoles as modulators of RORγt |
JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
EP3101006A1 (en) * | 2015-06-05 | 2016-12-07 | Lead Pharma Cel Models IP B.V. | Ror gamma (rory) modulators |
EP3170822A1 (en) | 2015-11-18 | 2017-05-24 | AGV Discovery | Azaindole derivatives and their use as erk kinase inhibitors |
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