UA107782C2 - Антагонисты рецепторов fgf-r4 - Google Patents

Антагонисты рецепторов fgf-r4

Info

Publication number
UA107782C2
UA107782C2 UAA201101398A UAA201101398A UA107782C2 UA 107782 C2 UA107782 C2 UA 107782C2 UA A201101398 A UAA201101398 A UA A201101398A UA A201101398 A UAA201101398 A UA A201101398A UA 107782 C2 UA107782 C2 UA 107782C2
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UA
Ukraine
Prior art keywords
receptor
fgf
specific antagonist
inhibition
activity
Prior art date
Application number
UAA201101398A
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English (en)
Ukrainian (uk)
Inventor
Ніколя Борен
П'єр-Франсуа Берн
Франсіс Бланш
Франсуаз Боно
Беатріс Камерон
Тарік Дабдубі
Корантен Ербер
Венсан Міколь
Елізабет Ремі
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Санофі-Авентіс
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40626849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA107782(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофі-Авентіс filed Critical Санофі-Авентіс
Publication of UA107782C2 publication Critical patent/UA107782C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение касается молекул, которые являются специфическими антагонистами рецептора FGF-R4 и позволяют ингибировать активность этого рецептора. Эти антагонисты представляют собой, в частности, антитела, специфически направленные к рецептору FGF-R4 и позволяют ингибировать активность этого рецептора. Изобретение касается также терапевтического применения таких антител, преимущественно, в области ангиогенеза и в лечении некоторых видов рака.
UAA201101398A 2008-07-08 2009-07-07 Антагонисты рецепторов fgf-r4 UA107782C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0803888A FR2933702A1 (fr) 2008-07-08 2008-07-08 Antagonistes specifiques du recepteur fgf-r4
PCT/FR2009/051343 WO2010004204A2 (fr) 2008-07-08 2009-07-07 Antagonistes specifiques du recepteur fgf-r4

Publications (1)

Publication Number Publication Date
UA107782C2 true UA107782C2 (ru) 2015-02-25

Family

ID=40626849

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201101398A UA107782C2 (ru) 2008-07-08 2009-07-07 Антагонисты рецепторов fgf-r4

Country Status (38)

Country Link
US (1) US20110150903A1 (ru)
EP (1) EP2315781B1 (ru)
JP (2) JP5726731B2 (ru)
KR (1) KR20110028536A (ru)
CN (2) CN102149730B (ru)
AR (1) AR072699A1 (ru)
AU (1) AU2009267834B2 (ru)
BR (1) BRPI0915660A2 (ru)
CA (1) CA2730300A1 (ru)
CL (1) CL2011000047A1 (ru)
CO (1) CO6440535A2 (ru)
CR (1) CR11868A (ru)
CY (1) CY1116847T1 (ru)
DK (1) DK2315781T3 (ru)
DO (1) DOP2011000005A (ru)
EA (2) EA021580B1 (ru)
EC (1) ECSP11010748A (ru)
ES (1) ES2544761T3 (ru)
FR (1) FR2933702A1 (ru)
HK (1) HK1159133A1 (ru)
HN (1) HN2011000074A (ru)
HR (1) HRP20150836T1 (ru)
HU (1) HUE027221T2 (ru)
IL (1) IL210516A0 (ru)
MA (1) MA32547B1 (ru)
MX (1) MX2011000328A (ru)
NI (1) NI201100012A (ru)
NZ (2) NZ602905A (ru)
PE (1) PE20110313A1 (ru)
PL (1) PL2315781T3 (ru)
PT (1) PT2315781E (ru)
SG (1) SG10201403751XA (ru)
SI (1) SI2315781T1 (ru)
TW (1) TW201006492A (ru)
UA (1) UA107782C2 (ru)
UY (1) UY31970A (ru)
WO (1) WO2010004204A2 (ru)
ZA (1) ZA201100209B (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107090045A (zh) * 2010-05-03 2017-08-25 霍夫曼-拉罗奇有限公司 用于肿瘤诊断和治疗的组合物和方法
US8906649B2 (en) 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
JP6126991B2 (ja) * 2010-09-27 2017-05-10 ヤンセン バイオテツク，インコーポレーテツド ヒトｉｉ型コラーゲンに結合する抗体
CN103596983B (zh) * 2011-04-07 2016-10-26 霍夫曼-拉罗奇有限公司 抗fgfr4抗体及使用方法
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
CN102219860B (zh) * 2011-05-20 2012-09-12 烟台荣昌生物工程有限公司 FGFR-Fc融合蛋白及其用途
US20140294820A1 (en) * 2011-06-24 2014-10-02 University Of Miami Fibroblast growth factor receptor inhibition for the treatment of disease
KR102077721B1 (ko) 2011-07-01 2020-02-14 엔지엠 바이오파마슈티컬스, 아이엔씨. 대사성 장애 및 질환의 치료를 위한 조성물, 용도 및 방법
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
WO2014085365A2 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
CN108888757A (zh) 2012-12-27 2018-11-27 恩格姆生物制药公司 用于调节胆汁酸体内稳态及治疗胆汁酸紊乱和疾病的方法
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
WO2014105849A1 (en) * 2012-12-28 2014-07-03 Xoma (Us) Llc Antibodies specific for fgfr4 and methods of use
WO2014165287A1 (en) * 2013-03-12 2014-10-09 The Translational Genomics Research Institute Hybridoma clones and monoclonal antibodies to fibroblast growth factor 4
US9957313B2 (en) 2013-03-15 2018-05-01 Remegen, Ltd. FGFR-FC fusion proteins and the use thereof
ES2682493T3 (es) 2013-10-25 2018-09-20 Novartis Ag Compuestos derivados de piridilo bicíclicos fusionados a anillo como inhibidores de FGFR4
WO2015065897A1 (en) 2013-10-28 2015-05-07 Ngm Biopharmaceuticals, Inc. Cancer models and associated methods
TW201612518A (en) * 2014-01-17 2016-04-01 Sanofi Sa Methods of identifying patients suffering from liver cancer who will most likely benefit from a treatment with an antagonist anti-FGFR4 antibody
RU2701434C2 (ru) 2014-01-24 2019-09-26 Нгм Биофармасьютикалс, Инк. Связывающие белки и способы их применения
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
WO2015195509A2 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
MA40354A (fr) 2014-07-18 2017-05-24 Sanofi Sa Procédé permettant de prédire le résultat d'un traitement avec de l'aflibercept d'un patient suspecté de souffrir d'un cancer
CN104177492B (zh) * 2014-07-21 2017-02-22 暨南大学 FGFR2c胞外段类似物及其编码基因与应用
PL3180356T3 (pl) * 2014-08-11 2020-04-30 Daiichi Sankyo Europe Gmbh Ludzkie przeciwciało anty-fgfr4
US20180185341A1 (en) 2014-10-03 2018-07-05 Novartis Ag Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
EP3209681A4 (en) 2014-10-23 2018-10-31 NGM Biopharmaceuticals, Inc. Pharmaceutical compositions comprising peptide variants and methods of use thereof
WO2016073855A1 (en) 2014-11-07 2016-05-12 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
CN107667092B (zh) 2015-03-25 2021-05-28 诺华股份有限公司 作为fgfr4抑制剂的甲酰化n-杂环衍生物
EP3095465A1 (en) 2015-05-19 2016-11-23 U3 Pharma GmbH Combination of fgfr4-inhibitor and bile acid sequestrant
WO2017019957A2 (en) 2015-07-29 2017-02-02 Ngm Biopharmaceuticals, Inc. Binding proteins and methods of use thereof
US10744185B2 (en) 2015-11-09 2020-08-18 Ngm Biopharmaceuticals, Inc. Methods of using variants of FGF19 polypeptides for the treatment of pruritus
MA43416A (fr) 2015-12-11 2018-10-17 Regeneron Pharma Méthodes pour ralentir ou empêcher la croissance de tumeurs résistantes au blocage de l'egfr et/ou d'erbb3
US10995143B2 (en) 2016-02-10 2021-05-04 Daiichi Sankyo Europe Gmbh Combination of human anti-FGFR4 antibody and Sorafenib
UA125898C2 (uk) 2016-03-04 2022-07-06 Джн Байосайєнсіз, Ллк Антитіла до tigit
WO2018039557A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
WO2018055503A1 (en) 2016-09-20 2018-03-29 Novartis Ag Combination comprising a pd-1 antagonist and an fgfr4 inhibitor
PL3534902T3 (pl) 2016-11-02 2023-03-27 Novartis Ag Skojarzenia inhibitorów fgfr4 i sekwestrantów kwasów żółciowych
EP3544998A1 (en) * 2016-11-22 2019-10-02 Merck Patent GmbH Monoclonal antibody directed to fgfr1
EP3444275A1 (en) * 2017-08-16 2019-02-20 Exiris S.r.l. Monoclonal antibody anti-fgfr4
CN109725159B (zh) * 2018-12-28 2021-10-08 江苏众红生物工程创药研究院有限公司 人β2-微球蛋白的定量检测试纸卡与临床应用
EP4093430A4 (en) * 2020-01-21 2024-01-24 Tavotek Biotherapeutics (Hong Kong) Limited AGENTS THAT INTERFERE WITH IL-1 RECEPTOR SIGNALING?
JP2023528036A (ja) 2020-06-02 2023-07-03 アーカス バイオサイエンシズ インコーポレイティド Ｔｉｇｉｔに対する抗体
WO2022098662A2 (en) * 2020-11-03 2022-05-12 Twist Bioscience Corporation Methods and compositions relating to chemokine receptor variants
CN118108840A (zh) * 2022-11-29 2024-05-31 中国科学院深圳先进技术研究院 抗fgfr4单克隆抗体、靶向fgfr4的嵌合抗原受体t细胞及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) * 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
PT1680140E (pt) * 2003-10-16 2011-05-31 Imclone Llc Inibidores do receptor-1 do factor de crescimento de fibroblastos e m?todos de tratamento destes
EP1989230B1 (en) * 2006-02-10 2016-06-01 Genentech, Inc. Anti-fgf19 antibodies and methods using same
US8394927B2 (en) * 2006-11-03 2013-03-12 U3 Pharma Gmbh FGFR4 antibodies
EP1918376A1 (en) * 2006-11-03 2008-05-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs
RU2009136669A (ru) * 2007-03-09 2011-04-20 Новартис АГ (CH) Лечение меланомы

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Publication number Publication date
CO6440535A2 (es) 2012-05-15
AR072699A1 (es) 2010-09-15
HRP20150836T1 (hr) 2015-09-11
NZ602905A (en) 2014-05-30
JP2011527322A (ja) 2011-10-27
IL210516A0 (en) 2011-03-31
CN102149730B (zh) 2014-03-26
AU2009267834A1 (en) 2010-01-14
HUE027221T2 (en) 2016-10-28
NI201100012A (es) 2011-07-20
CA2730300A1 (fr) 2010-01-14
SG10201403751XA (en) 2014-09-26
EA021580B1 (ru) 2015-07-30
BRPI0915660A2 (pt) 2019-08-27
US20110150903A1 (en) 2011-06-23
MX2011000328A (es) 2011-04-05
JP5726731B2 (ja) 2015-06-03
UY31970A (es) 2010-02-26
CR11868A (es) 2011-02-16
CN102149730A (zh) 2011-08-10
KR20110028536A (ko) 2011-03-18
FR2933702A1 (fr) 2010-01-15
EA201401107A1 (ru) 2015-05-29
SI2315781T1 (sl) 2015-09-30
ES2544761T3 (es) 2015-09-03
ECSP11010748A (es) 2011-02-28
PE20110313A1 (es) 2011-06-21
CN103784954A (zh) 2014-05-14
WO2010004204A3 (fr) 2010-04-29
CL2011000047A1 (es) 2011-07-08
HK1159133A1 (en) 2012-07-27
EP2315781B1 (fr) 2015-05-06
NZ590860A (en) 2012-12-21
EA201170155A1 (ru) 2011-08-30
PT2315781E (pt) 2015-09-21
WO2010004204A2 (fr) 2010-01-14
ZA201100209B (en) 2012-04-25
JP2015057398A (ja) 2015-03-26
TW201006492A (en) 2010-02-16
EP2315781A2 (fr) 2011-05-04
DK2315781T3 (en) 2015-08-10
AU2009267834B2 (en) 2014-10-23
HN2011000074A (es) 2013-01-28
PL2315781T3 (pl) 2015-10-30
CY1116847T1 (el) 2017-03-15
MA32547B1 (fr) 2011-08-01
DOP2011000005A (es) 2011-02-15

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