CY1116847T1 - Ειδικοι ανταγωνιστες του υποδοχεα fgf-r4 - Google Patents

Ειδικοι ανταγωνιστες του υποδοχεα fgf-r4

Info

Publication number
CY1116847T1
CY1116847T1 CY20151100681T CY151100681T CY1116847T1 CY 1116847 T1 CY1116847 T1 CY 1116847T1 CY 20151100681 T CY20151100681 T CY 20151100681T CY 151100681 T CY151100681 T CY 151100681T CY 1116847 T1 CY1116847 T1 CY 1116847T1
Authority
CY
Cyprus
Prior art keywords
fgf
receptor
receptor specific
specific antagonists
antibodies
Prior art date
Application number
CY20151100681T
Other languages
English (en)
Inventor
Nicolas Baurin
Pierre-François Berne
Francis Blanche
Françoise Bono
Béatrice Cameron
Tarik Dabdoubi
Corentin Herbert
Vincent Mikol
Elisabeth Remy
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40626849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116847(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi filed Critical Sanofi
Publication of CY1116847T1 publication Critical patent/CY1116847T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση έχει ως αντικείμενο της μόρια ειδικών ανταγωνιστών του υποδοχέα FGF-R4, τα οποία επιτρέπουν την αναστολή της δραστικότητας του υποδοχέα. Αυτοί οι ανταγωνιστές είναι, συγκεκριμένα, αντισώματα τα οποία κατευθύνονται ειδικότερα έναντι του υποδοχέα FGF-R4, επιτρέποντας την αναστολή της δραστικότητας του εν λόγω υποδοχέα. Η παρούσα εφεύρεση έχει επίσης ως αντικείμενο της τη θεραπευτική χρήση των εν λόγω αντισωμάτων, ιδιαίτερα δε στο πεδίο της αγγειογένεσης, και στην θεραπεία ορισμένων τύπων του καρκίνου.
CY20151100681T 2008-07-08 2015-08-05 Ειδικοι ανταγωνιστες του υποδοχεα fgf-r4 CY1116847T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0803888A FR2933702A1 (fr) 2008-07-08 2008-07-08 Antagonistes specifiques du recepteur fgf-r4
EP09784478.1A EP2315781B1 (fr) 2008-07-08 2009-07-07 Antagonistes specifiques du recepteur fgf-r4

Publications (1)

Publication Number Publication Date
CY1116847T1 true CY1116847T1 (el) 2017-03-15

Family

ID=40626849

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100681T CY1116847T1 (el) 2008-07-08 2015-08-05 Ειδικοι ανταγωνιστες του υποδοχεα fgf-r4

Country Status (38)

Country Link
US (1) US20110150903A1 (el)
EP (1) EP2315781B1 (el)
JP (2) JP5726731B2 (el)
KR (1) KR20110028536A (el)
CN (2) CN102149730B (el)
AR (1) AR072699A1 (el)
AU (1) AU2009267834B2 (el)
BR (1) BRPI0915660A2 (el)
CA (1) CA2730300A1 (el)
CL (1) CL2011000047A1 (el)
CO (1) CO6440535A2 (el)
CR (1) CR11868A (el)
CY (1) CY1116847T1 (el)
DK (1) DK2315781T3 (el)
DO (1) DOP2011000005A (el)
EA (2) EA201401107A1 (el)
EC (1) ECSP11010748A (el)
ES (1) ES2544761T3 (el)
FR (1) FR2933702A1 (el)
HK (1) HK1159133A1 (el)
HN (1) HN2011000074A (el)
HR (1) HRP20150836T1 (el)
HU (1) HUE027221T2 (el)
IL (1) IL210516A0 (el)
MA (1) MA32547B1 (el)
MX (1) MX2011000328A (el)
NI (1) NI201100012A (el)
NZ (2) NZ590860A (el)
PE (1) PE20110313A1 (el)
PL (1) PL2315781T3 (el)
PT (1) PT2315781E (el)
SG (1) SG10201403751XA (el)
SI (1) SI2315781T1 (el)
TW (1) TW201006492A (el)
UA (1) UA107782C2 (el)
UY (1) UY31970A (el)
WO (1) WO2010004204A2 (el)
ZA (1) ZA201100209B (el)

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Also Published As

Publication number Publication date
CR11868A (es) 2011-02-16
MA32547B1 (fr) 2011-08-01
PL2315781T3 (pl) 2015-10-30
EP2315781A2 (fr) 2011-05-04
DK2315781T3 (en) 2015-08-10
CN102149730B (zh) 2014-03-26
UY31970A (es) 2010-02-26
WO2010004204A2 (fr) 2010-01-14
EA201401107A1 (ru) 2015-05-29
EP2315781B1 (fr) 2015-05-06
ES2544761T3 (es) 2015-09-03
HRP20150836T1 (hr) 2015-09-11
PE20110313A1 (es) 2011-06-21
HN2011000074A (es) 2013-01-28
NZ590860A (en) 2012-12-21
JP2015057398A (ja) 2015-03-26
SG10201403751XA (en) 2014-09-26
UA107782C2 (ru) 2015-02-25
BRPI0915660A2 (pt) 2019-08-27
PT2315781E (pt) 2015-09-21
CA2730300A1 (fr) 2010-01-14
US20110150903A1 (en) 2011-06-23
SI2315781T1 (sl) 2015-09-30
ECSP11010748A (es) 2011-02-28
AU2009267834B2 (en) 2014-10-23
ZA201100209B (en) 2012-04-25
MX2011000328A (es) 2011-04-05
CO6440535A2 (es) 2012-05-15
TW201006492A (en) 2010-02-16
DOP2011000005A (es) 2011-02-15
CL2011000047A1 (es) 2011-07-08
FR2933702A1 (fr) 2010-01-15
CN102149730A (zh) 2011-08-10
EA201170155A1 (ru) 2011-08-30
KR20110028536A (ko) 2011-03-18
JP5726731B2 (ja) 2015-06-03
NI201100012A (es) 2011-07-20
NZ602905A (en) 2014-05-30
WO2010004204A3 (fr) 2010-04-29
HK1159133A1 (en) 2012-07-27
IL210516A0 (en) 2011-03-31
CN103784954A (zh) 2014-05-14
AR072699A1 (es) 2010-09-15
AU2009267834A1 (en) 2010-01-14
EA021580B1 (ru) 2015-07-30
HUE027221T2 (en) 2016-10-28
JP2011527322A (ja) 2011-10-27

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