PL1680140T3 - Inhibitory receptora-1 czynnika wzrostu fibroblastów i związane z nim sposoby leczenia - Google Patents
Inhibitory receptora-1 czynnika wzrostu fibroblastów i związane z nim sposoby leczeniaInfo
- Publication number
- PL1680140T3 PL1680140T3 PL04796034T PL04796034T PL1680140T3 PL 1680140 T3 PL1680140 T3 PL 1680140T3 PL 04796034 T PL04796034 T PL 04796034T PL 04796034 T PL04796034 T PL 04796034T PL 1680140 T3 PL1680140 T3 PL 1680140T3
- Authority
- PL
- Poland
- Prior art keywords
- fgfr
- methods
- treatment
- growth factor
- factor receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51225503P | 2003-10-16 | 2003-10-16 | |
| EP04796034A EP1680140B1 (en) | 2003-10-16 | 2004-10-18 | Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof |
| PCT/US2004/034970 WO2005037235A2 (en) | 2003-10-16 | 2004-10-18 | Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1680140T3 true PL1680140T3 (pl) | 2011-11-30 |
Family
ID=34465334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04796034T PL1680140T3 (pl) | 2003-10-16 | 2004-10-18 | Inhibitory receptora-1 czynnika wzrostu fibroblastów i związane z nim sposoby leczenia |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070274981A1 (pl) |
| EP (3) | EP2229955A1 (pl) |
| JP (1) | JP4686465B2 (pl) |
| AT (1) | ATE506077T1 (pl) |
| CA (2) | CA2542638A1 (pl) |
| CY (1) | CY1111479T1 (pl) |
| DE (1) | DE602004032370D1 (pl) |
| DK (1) | DK1680140T3 (pl) |
| ES (1) | ES2361917T3 (pl) |
| PL (1) | PL1680140T3 (pl) |
| PT (1) | PT1680140E (pl) |
| SI (1) | SI1680140T1 (pl) |
| WO (1) | WO2005037235A2 (pl) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US20050282733A1 (en) * | 2002-06-27 | 2005-12-22 | Prins Johannes B | Differentiation modulating agents and uses therefor |
| WO2005037235A2 (en) | 2003-10-16 | 2005-04-28 | Imclone Systems Incorporated | Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof |
| CN102225926A (zh) * | 2003-11-07 | 2011-10-26 | 诺华疫苗和诊断公司 | 具有改进药物特性的喹啉酮类化合物的药学上可接受的盐 |
| JPWO2006011686A1 (ja) * | 2004-07-30 | 2008-05-01 | 日本たばこ産業株式会社 | C型肝炎ウイルス(hcv)の細胞感染を阻害する化合物のスクリーニング方法 |
| EP1882475A1 (en) * | 2006-07-26 | 2008-01-30 | Novartis AG | Method of treating disorders mediated by the fibroblast growth factor receptor |
| WO2009046141A2 (en) * | 2007-10-01 | 2009-04-09 | Isis Pharmaceuticals, Inc. | Antisense modulation of fibroblast growth factor receptor 4 expression |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| EP2296690B1 (en) | 2008-06-04 | 2016-11-30 | Amgen, Inc | Fgf21 mutants and uses thereof |
| FR2933702A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
| JP5878757B2 (ja) | 2008-10-10 | 2016-03-08 | アムジエン・インコーポレーテツド | Fgf21変異体およびその使用 |
| EP2408814B1 (en) | 2009-03-20 | 2018-11-21 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| CA2758842A1 (en) | 2009-04-24 | 2010-10-28 | Glaxo Group Limited | Fgfr1c antibody combinations |
| HRP20240135T1 (hr) | 2009-05-05 | 2024-04-12 | Amgen Inc. | Fgf21 mutanti i njihove upotrebe |
| EP2427207B1 (en) | 2009-05-05 | 2017-08-16 | Amgen, Inc | Fgf21 mutants and uses thereof |
| US8324160B2 (en) | 2009-06-17 | 2012-12-04 | Amgen Inc. | Chimeric polypeptides and uses thereof |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| EP2679234A3 (en) | 2009-12-02 | 2014-04-23 | Amgen Inc. | Binding proteins that bind to human FGFR1C, human beta-klotho and both human FGFR1C and human beta-klotho |
| UA109888C2 (uk) * | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| AU2014250730B2 (en) * | 2009-12-07 | 2016-10-13 | Amgen Inc. | Human antigen binding proteins that bind beta-Klotho, FGF receptors and complexes thereof |
| CA2796055A1 (en) | 2010-04-15 | 2011-10-20 | Amgen Inc. | Human fgf receptor and .beta.-klotho binding proteins |
| WO2012015674A1 (en) | 2010-07-26 | 2012-02-02 | Eli Lilly And Company | THERAPEUTIC USES OF AN FGFR1c ANTIBODY |
| WO2012040518A2 (en) | 2010-09-22 | 2012-03-29 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| AU2011342161C1 (en) | 2010-12-15 | 2016-03-17 | Kyowa Kirin Co., Ltd. | Process for production of protein |
| RU2440142C1 (ru) * | 2011-02-07 | 2012-01-20 | Общество С Ограниченной Ответственностью "Онкомакс" | Антитело, останавливающее или замедляющее рост опухоли (варианты), способ подавления роста опухоли, способ диагностики злокачественных образований |
| SG185832A1 (en) * | 2011-05-10 | 2012-12-28 | Agency Science Tech & Res | Fgfr1 antibodies and treatment of cancer |
| CA2828890A1 (en) * | 2011-04-07 | 2012-10-11 | Genentech, Inc. | Anti-fgfr4 antibodies and methods of use |
| SI2710035T1 (sl) | 2011-05-16 | 2017-07-31 | F. Hoffmann-La Roche Ag | Agonisti FGFR1 in tehnike njihove uporabe |
| WO2012158818A2 (en) | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| WO2012174476A2 (en) | 2011-06-16 | 2012-12-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of fibroblast growth factor receptor 4 expression |
| WO2012177481A2 (en) * | 2011-06-24 | 2012-12-27 | University Of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| EP2748197A2 (en) | 2011-08-26 | 2014-07-02 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
| KR20150123250A (ko) | 2013-03-06 | 2015-11-03 | 제넨테크, 인크. | 암 약물 내성의 치료 및 예방 방법 |
| TW201444872A (zh) | 2013-03-06 | 2014-12-01 | Merrimack Pharmaceuticals Inc | 抗C-MET串聯Fc雙特異性抗體 |
| PH12021552742A1 (en) | 2013-08-01 | 2022-05-23 | Five Prime Therapeutics Inc | Afucosylated anti-fgfr2iiib antibodies |
| TWI728373B (zh) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | 抗體及使用方法 |
| CA2943355C (en) | 2014-03-25 | 2023-09-05 | Regeneron Pharmaceuticals, Inc. | Fgf21 receptor agonists and uses thereof |
| CN107073121A (zh) | 2014-06-13 | 2017-08-18 | 基因泰克公司 | 治疗及预防癌症药物抗性的方法 |
| JP6865688B2 (ja) | 2015-01-16 | 2021-04-28 | ジュノー セラピューティクス インコーポレイテッド | Ror1に特異的な抗体およびキメラ抗原受容体 |
| RU2017134379A (ru) * | 2015-03-25 | 2019-04-03 | Новартис Аг | Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4 |
| CA3289997A1 (en) | 2015-09-20 | 2026-03-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal Antibodies Specific for Fibroblast Growth Factor Receptor 4 (FGFR4) and Methods of Their Use |
| EP3371217B1 (en) | 2015-11-08 | 2025-06-11 | F. Hoffmann-La Roche AG | Methods of screening for multispecific antibodies |
| US20170145103A1 (en) | 2015-11-23 | 2017-05-25 | Five Prime Therapeutics, Inc. | Predicting response to cancer treatment with fgfr2 inhibitors |
| JP2018536682A (ja) | 2015-12-11 | 2018-12-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Egfr及び/またはerbb3遮断に耐性のある腫瘍の成長を低減または防止するための方法 |
| CN108699149B (zh) | 2016-02-02 | 2023-01-06 | 弗雷德哈钦森癌症中心 | 抗-ror1抗体及其用途 |
| CN109476756B (zh) | 2016-03-15 | 2022-05-31 | 埃泰美德(香港)有限公司 | 一种多特异性Fab融合蛋白及其用途 |
| WO2018095932A1 (en) | 2016-11-22 | 2018-05-31 | Merck Patent Gmbh | Monoclonal antibody directed to fgfr1 |
| WO2018129451A2 (en) | 2017-01-09 | 2018-07-12 | Merrimack Pharmaceuticals, Inc. | Anti-fgfr antibodies and methods of use |
| SG10202112636SA (en) | 2017-05-16 | 2021-12-30 | Five Prime Therapeutics Inc | Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment |
| EP3444275A1 (en) | 2017-08-16 | 2019-02-20 | Exiris S.r.l. | Monoclonal antibody anti-fgfr4 |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| WO2020132810A1 (en) | 2018-12-24 | 2020-07-02 | Generon (Shanghai) Corporation Ltd. | Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof |
| US20230052256A1 (en) * | 2019-12-24 | 2023-02-16 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Novel anti-fgfr2b antibodies |
| CA3160810A1 (en) * | 2019-12-24 | 2021-07-01 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Novel anti-fgfr2b antibodies |
| IL308183A (en) | 2021-05-04 | 2024-01-01 | Regeneron Pharma | Multispecific FGF21 receptor agonists and their uses |
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2004
- 2004-10-18 WO PCT/US2004/034970 patent/WO2005037235A2/en not_active Ceased
- 2004-10-18 AT AT04796034T patent/ATE506077T1/de active
- 2004-10-18 EP EP10162585A patent/EP2229955A1/en not_active Withdrawn
- 2004-10-18 ES ES04796034T patent/ES2361917T3/es not_active Expired - Lifetime
- 2004-10-18 DE DE602004032370T patent/DE602004032370D1/de not_active Expired - Lifetime
- 2004-10-18 JP JP2006535458A patent/JP4686465B2/ja not_active Expired - Fee Related
- 2004-10-18 PT PT04796034T patent/PT1680140E/pt unknown
- 2004-10-18 US US10/575,977 patent/US20070274981A1/en not_active Abandoned
- 2004-10-18 CA CA002542638A patent/CA2542638A1/en not_active Abandoned
- 2004-10-18 CA CA2762955A patent/CA2762955A1/en not_active Abandoned
- 2004-10-18 EP EP04796034A patent/EP1680140B1/en not_active Expired - Lifetime
- 2004-10-18 PL PL04796034T patent/PL1680140T3/pl unknown
- 2004-10-18 SI SI200431700T patent/SI1680140T1/sl unknown
- 2004-10-18 EP EP08020599A patent/EP2060270A3/en not_active Withdrawn
- 2004-10-18 DK DK04796034.9T patent/DK1680140T3/da active
-
2011
- 2011-05-20 CY CY20111100497T patent/CY1111479T1/el unknown
- 2011-12-16 US US13/328,147 patent/US8263074B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1680140A2 (en) | 2006-07-19 |
| EP2060270A3 (en) | 2009-12-09 |
| DK1680140T3 (da) | 2011-06-14 |
| JP2008501302A (ja) | 2008-01-24 |
| EP1680140B1 (en) | 2011-04-20 |
| CY1111479T1 (el) | 2015-08-05 |
| ES2361917T3 (es) | 2011-06-24 |
| EP1680140A4 (en) | 2007-12-05 |
| SI1680140T1 (sl) | 2011-08-31 |
| CA2762955A1 (en) | 2005-04-28 |
| PT1680140E (pt) | 2011-05-31 |
| JP4686465B2 (ja) | 2011-05-25 |
| WO2005037235A2 (en) | 2005-04-28 |
| DE602004032370D1 (de) | 2011-06-01 |
| WO2005037235A3 (en) | 2005-12-22 |
| EP2229955A1 (en) | 2010-09-22 |
| US8263074B2 (en) | 2012-09-11 |
| US20120121609A1 (en) | 2012-05-17 |
| ATE506077T1 (de) | 2011-05-15 |
| EP2060270A2 (en) | 2009-05-20 |
| US20070274981A1 (en) | 2007-11-29 |
| CA2542638A1 (en) | 2005-04-28 |
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