UA104140C2 - Benzofurane, benzothiophene, benzothiazol derivatives as fxr modulators - Google Patents

Benzofurane, benzothiophene, benzothiazol derivatives as fxr modulators

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Publication number
UA104140C2
UA104140C2 UAA201013540A UAA201013540A UA104140C2 UA 104140 C2 UA104140 C2 UA 104140C2 UA A201013540 A UAA201013540 A UA A201013540A UA A201013540 A UAA201013540 A UA A201013540A UA 104140 C2 UA104140 C2 UA 104140C2
Authority
UA
Ukraine
Prior art keywords
benzofurane
benzothiophene
fxr modulators
benzothiazol
derivatives
Prior art date
Application number
UAA201013540A
Other languages
English (en)
Ukrainian (uk)
Inventor
Дидье Роше
Жизель Маутино
Инго Кобер
Франсис Контард
Серж Кристманн-Франк
Саумитра Сенгупта
Рамеш Систла
Рао Гуммади Венкатешвар
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39769187&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA104140(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of UA104140C2 publication Critical patent/UA104140C2/ru

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
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  • Biochemistry (AREA)
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  • Pain & Pain Management (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Производные бензофурана, бензотиофена, бензотиазола как FXR модуляторы.Данное изобретение касается соединений формулы (I), в которых заместители имеют значения, указанные в пунктах формулы изобретения, включая их фармацевтические композиции и их применение для лечения и/или профилактики, и/или облегчения одного или нескольких симптомов заболевания или нарушения, связанного с активностью FXR.Изобретение также относится к промежуточным соединениям и к способу получения соединений формулы (I).(I).
UAA201013540A 2008-04-18 2009-03-30 Benzofurane, benzothiophene, benzothiazol derivatives as fxr modulators UA104140C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08300183A EP2110374A1 (en) 2008-04-18 2008-04-18 Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
PCT/EP2009/002297 WO2009127321A1 (en) 2008-04-18 2009-03-30 Benzofurane, benzothiophene, benzothiazol derivatives as fxr modulators

Publications (1)

Publication Number Publication Date
UA104140C2 true UA104140C2 (en) 2014-01-10

Family

ID=39769187

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201013540A UA104140C2 (en) 2008-04-18 2009-03-30 Benzofurane, benzothiophene, benzothiazol derivatives as fxr modulators

Country Status (27)

Country Link
US (1) US8575161B2 (ru)
EP (2) EP2110374A1 (ru)
JP (2) JP5616326B2 (ru)
KR (1) KR101662853B1 (ru)
CN (1) CN101990535B (ru)
AR (1) AR071207A1 (ru)
AU (1) AU2009238015B2 (ru)
BR (1) BRPI0911243B8 (ru)
CA (1) CA2721591C (ru)
CO (1) CO6311099A2 (ru)
CY (1) CY1116333T1 (ru)
DK (1) DK2262785T3 (ru)
EA (1) EA020454B1 (ru)
EC (1) ECSP10010615A (ru)
ES (1) ES2531006T3 (ru)
HK (1) HK1155741A1 (ru)
HR (1) HRP20150319T1 (ru)
IL (1) IL208322A (ru)
MX (1) MX2010011292A (ru)
MY (1) MY156530A (ru)
NZ (1) NZ589327A (ru)
PL (1) PL2262785T3 (ru)
PT (1) PT2262785E (ru)
SI (1) SI2262785T1 (ru)
UA (1) UA104140C2 (ru)
WO (1) WO2009127321A1 (ru)
ZA (1) ZA201008243B (ru)

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