TWI841576B - 用於治療傳染病之共受體系統 - Google Patents

用於治療傳染病之共受體系統 Download PDF

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TWI841576B
TWI841576B TW108124666A TW108124666A TWI841576B TW I841576 B TWI841576 B TW I841576B TW 108124666 A TW108124666 A TW 108124666A TW 108124666 A TW108124666 A TW 108124666A TW I841576 B TWI841576 B TW I841576B
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cells
domain
immune cell
cell
ccr5
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TW108124666A
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TW202019954A (zh
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曾明
陳路
武術
陳麗麗
劉勛
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大陸商南京傳奇生物科技有限公司
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/41—Vertebrate antigens
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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TW108124666A 2018-07-13 2019-07-12 用於治療傳染病之共受體系統 TWI841576B (zh)

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CN2018095650 2018-07-13
WOPCT/CN2018/095650 2018-07-13
WOPCT/CN2019/087259 2019-05-16
CN2019087259 2019-05-16

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US (1) US20210275589A1 (enExample)
EP (1) EP3820888A4 (enExample)
JP (1) JP7447388B2 (enExample)
KR (1) KR20210031898A (enExample)
CN (1) CN112334479A (enExample)
AU (1) AU2019302603A1 (enExample)
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AU2017292582C1 (en) 2016-07-08 2021-11-11 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
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US11352646B2 (en) 2018-11-05 2022-06-07 American Gene Technologies International Inc. Vector system for expressing regulatory RNA
AU2020275049A1 (en) * 2019-05-16 2022-01-06 Nanjing Legend Biotech Co., Ltd. Engineered immune cells comprsing a recognition molecule
WO2021178571A1 (en) * 2020-03-03 2021-09-10 American Gene Technologies International Inc. On demand expression of exogenous factors in lymphocytes to treat hiv
WO2021180832A1 (en) 2020-03-12 2021-09-16 Universiteit Gent Hybrid car and hybrid tcr cells to treat infectious diseases
US12497623B2 (en) * 2020-05-04 2025-12-16 The Trustees Of The University Of Pennsylvania Non-signaling HIV fusion inhibitors and methods of use thereof
EP4291573A4 (en) * 2021-02-09 2025-01-29 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof
WO2025011508A1 (zh) * 2023-07-07 2025-01-16 深圳先进技术研究院 降低肿瘤内中性粒细胞水平的抗肿瘤细菌
CN120329439A (zh) * 2024-01-18 2025-07-18 中国人民解放军军事科学院军事医学研究院 一种单克隆抗体及其应用
CN121015699B (zh) * 2025-08-21 2026-04-10 广州淳泰生物医药科技有限公司 一种nkt细胞制剂及其制备方法和应用

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