CN112334479A - 用于治疗感染性疾病的共受体系统 - Google Patents

用于治疗感染性疾病的共受体系统 Download PDF

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Publication number
CN112334479A
CN112334479A CN201980041985.3A CN201980041985A CN112334479A CN 112334479 A CN112334479 A CN 112334479A CN 201980041985 A CN201980041985 A CN 201980041985A CN 112334479 A CN112334479 A CN 112334479A
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immune cell
cells
domain
engineered immune
cell
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Chinese (zh)
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曾明
陈路
武术
陈丽丽
刘勋
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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CN201980041985.3A 2018-07-13 2019-07-12 用于治疗感染性疾病的共受体系统 Pending CN112334479A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2018095650 2018-07-13
CNPCT/CN2018/095650 2018-07-13
CN2019087259 2019-05-16
CNPCT/CN2019/087259 2019-05-16
PCT/CN2019/095738 WO2020011247A1 (en) 2018-07-13 2019-07-12 Co-receptor systems for treating infectious diseases

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CN112334479A true CN112334479A (zh) 2021-02-05

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US (1) US20210275589A1 (enExample)
EP (1) EP3820888A4 (enExample)
JP (1) JP7447388B2 (enExample)
KR (1) KR20210031898A (enExample)
CN (1) CN112334479A (enExample)
AU (1) AU2019302603A1 (enExample)
SG (1) SG11202012339WA (enExample)
TW (1) TWI841576B (enExample)
WO (1) WO2020011247A1 (enExample)

Cited By (3)

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WO2022171068A1 (en) * 2021-02-09 2022-08-18 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof
WO2025153056A1 (zh) * 2024-01-18 2025-07-24 中国人民解放军军事科学院军事医学研究院 一种单克隆抗体及其应用
CN121015699A (zh) * 2025-08-21 2025-11-28 广州淳泰生物医药科技有限公司 一种nkt细胞制剂及其制备方法和应用

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CN116064678A (zh) 2016-01-15 2023-05-05 美国基因技术国际有限公司 用于活化γ-δT细胞的方法和组合物
WO2017156311A2 (en) 2016-03-09 2017-09-14 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
AU2017292582C1 (en) 2016-07-08 2021-11-11 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
JP2020524996A (ja) 2017-06-16 2020-08-27 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド ヒトガンマデルタｔ細胞を介する腫瘍細胞傷害性の活性化のための方法および組成物
US11352646B2 (en) 2018-11-05 2022-06-07 American Gene Technologies International Inc. Vector system for expressing regulatory RNA
AU2020275049A1 (en) * 2019-05-16 2022-01-06 Nanjing Legend Biotech Co., Ltd. Engineered immune cells comprsing a recognition molecule
WO2021178571A1 (en) * 2020-03-03 2021-09-10 American Gene Technologies International Inc. On demand expression of exogenous factors in lymphocytes to treat hiv
WO2021180832A1 (en) 2020-03-12 2021-09-16 Universiteit Gent Hybrid car and hybrid tcr cells to treat infectious diseases
US12497623B2 (en) * 2020-05-04 2025-12-16 The Trustees Of The University Of Pennsylvania Non-signaling HIV fusion inhibitors and methods of use thereof
WO2025011508A1 (zh) * 2023-07-07 2025-01-16 深圳先进技术研究院 降低肿瘤内中性粒细胞水平的抗肿瘤细菌

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