TWI832901B - 血紅素之測定試劑、測定套組及測定方法 - Google Patents
血紅素之測定試劑、測定套組及測定方法 Download PDFInfo
- Publication number
- TWI832901B TWI832901B TW108133784A TW108133784A TWI832901B TW I832901 B TWI832901 B TW I832901B TW 108133784 A TW108133784 A TW 108133784A TW 108133784 A TW108133784 A TW 108133784A TW I832901 B TWI832901 B TW I832901B
- Authority
- TW
- Taiwan
- Prior art keywords
- heme
- binding globulin
- antibody
- insoluble carrier
- specimen
- Prior art date
Links
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- 230000001900 immune effect Effects 0.000 description 6
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 5
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
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- 241000283086 Equidae Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
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- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
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- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
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- 241001272567 Hominoidea Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- 239000002532 enzyme inhibitor Substances 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- ZBKIUFWVEIBQRT-UHFFFAOYSA-N gold(1+) Chemical compound [Au+] ZBKIUFWVEIBQRT-UHFFFAOYSA-N 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 102000028546 heme binding Human genes 0.000 description 1
- 108091022907 heme binding Proteins 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
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- 238000010324 immunological assay Methods 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018-179952 | 2018-09-26 | ||
| JP2018179952 | 2018-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202020455A TW202020455A (zh) | 2020-06-01 |
| TWI832901B true TWI832901B (zh) | 2024-02-21 |
Family
ID=69951999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW108133784A TWI832901B (zh) | 2018-09-26 | 2019-09-19 | 血紅素之測定試劑、測定套組及測定方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12405277B2 (enExample) |
| EP (1) | EP3859338B1 (enExample) |
| JP (3) | JP7005785B2 (enExample) |
| KR (1) | KR102839014B1 (enExample) |
| CN (1) | CN112752974A (enExample) |
| AU (1) | AU2019350257B2 (enExample) |
| ES (1) | ES2987836T3 (enExample) |
| SG (1) | SG11202102265UA (enExample) |
| TW (1) | TWI832901B (enExample) |
| WO (1) | WO2020066722A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112752974A (zh) * | 2018-09-26 | 2021-05-04 | 荣研化学株式会社 | 血红蛋白的测定试剂、测定试剂盒和测定方法 |
| US11509681B2 (en) * | 2021-03-11 | 2022-11-22 | Virtustream Ip Holding Company Llc | Relative risk ranking of cloud assets used in multi-cloud workloads |
| CN115902201A (zh) * | 2022-10-14 | 2023-04-04 | 安徽惠邦生物工程有限公司 | 尿液中结合珠蛋白含量检测的化学发光免疫分析试剂盒及其分析方法 |
| TW202429079A (zh) * | 2022-11-16 | 2024-07-16 | 日商榮研化學股份有限公司 | 游離血紅素的測定方法及游離血紅素的測定試劑 |
| CN120659999A (zh) | 2023-02-27 | 2025-09-16 | 荣研化学株式会社 | 使用去糖基化结合珠蛋白的血红蛋白的免疫学检测方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0448072A2 (en) * | 1990-03-20 | 1991-09-25 | The Green Cross Corporation | Process for assaying free hemoglobin and reagent kit for assaying free hemoglobin |
| JPH11201969A (ja) * | 1998-01-14 | 1999-07-30 | Wakamoto Pharmaceut Co Ltd | 簡易遊離ヘモグロビン測定方法および測定用キット |
| JP2010014586A (ja) * | 2008-07-04 | 2010-01-21 | Wako Pure Chem Ind Ltd | 便検体中ヘモグロビンの測定方法及び測定試薬キット |
| EP3467498A1 (en) * | 2016-05-30 | 2019-04-10 | Eiken Kagaku Kabushiki Kaisha | Anti-human hemoglobin monoclonal antibody or antibody kit, insoluble carrier particle to which anti-human hemoglobin monoclonal antibody is immobilized, and measurement reagent and measurement method using same |
| TW201932838A (zh) * | 2017-12-01 | 2019-08-16 | 日商榮研化學股份有限公司 | 將血紅素與血紅素結合球蛋白之複合體安定化之方法、及用以保存含有血紅素之檢體之保存溶液 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3532868A1 (de) * | 1985-09-14 | 1987-03-26 | Boehringer Mannheim Gmbh | Verfahren und reagenz zur bestimmung von glykosiliertem haemoglobin sowie hierzu geeignete verbindungen und verfahren zu deren herstellung |
| JPH02193071A (ja) | 1989-01-20 | 1990-07-30 | Green Cross Corp:The | ハプトグロビン―ヘモグロビン複合体測定用試薬キット及びそれを用いるハプトグロビン―ヘモグロビン複合体の測定法 |
| JP3032891B2 (ja) | 1989-03-04 | 2000-04-17 | 吉富製薬株式会社 | 遊離ヘモグロビン測定用試薬キット及びそれを用いる遊離ヘモグロビンの測定法 |
| JP2654181B2 (ja) | 1989-05-10 | 1997-09-17 | 日東電工株式会社 | ヒトヘモグロビンの検出方法 |
| JPH05322889A (ja) | 1992-05-18 | 1993-12-07 | Toyobo Co Ltd | ハプトグロビン−ヘモグロビン複合体の定量方法およびハプトグロビン−ヘモグロビン複合体の定量キット |
| JPH05322888A (ja) | 1992-05-18 | 1993-12-07 | Toyobo Co Ltd | 遊離ヘモグロビンの定量方法および遊離ヘモグロビン定量キット |
| JPH07103978A (ja) | 1993-09-30 | 1995-04-21 | Wakamoto Pharmaceut Co Ltd | 遊離ヘモグロビン測定 |
| JPH08313530A (ja) | 1995-05-22 | 1996-11-29 | Wakamoto Pharmaceut Co Ltd | 総ヘモグロビン測定方法及び測定キット |
| JPH10132824A (ja) | 1996-10-28 | 1998-05-22 | Eiken Chem Co Ltd | ヘモグロビンの安定化方法 |
| JP4039590B2 (ja) | 1998-01-30 | 2008-01-30 | 栄研化学株式会社 | ヘモグロビン試料の安定化 |
| JPH11242027A (ja) | 1998-02-25 | 1999-09-07 | Eiken Chem Co Ltd | 免疫学的便潜血試験の精度管理方法 |
| WO2010013525A1 (ja) | 2008-07-31 | 2010-02-04 | 日東紡績株式会社 | 複合体の測定方法およびそれに用いるキット |
| JP5268606B2 (ja) | 2008-12-08 | 2013-08-21 | 日本化薬株式会社 | フェノール樹脂、エポキシ樹脂、エポキシ樹脂組成物およびその硬化物 |
| JP6434843B2 (ja) | 2015-03-31 | 2018-12-05 | 栄研化学株式会社 | ヘムタンパク質の保存液及びヘムタンパク質の安定化方法 |
| CN112752974A (zh) * | 2018-09-26 | 2021-05-04 | 荣研化学株式会社 | 血红蛋白的测定试剂、测定试剂盒和测定方法 |
-
2019
- 2019-09-13 CN CN201980062760.6A patent/CN112752974A/zh active Pending
- 2019-09-13 WO PCT/JP2019/036235 patent/WO2020066722A1/ja not_active Ceased
- 2019-09-13 AU AU2019350257A patent/AU2019350257B2/en active Active
- 2019-09-13 KR KR1020217011239A patent/KR102839014B1/ko active Active
- 2019-09-13 ES ES19866240T patent/ES2987836T3/es active Active
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| EP0448072A2 (en) * | 1990-03-20 | 1991-09-25 | The Green Cross Corporation | Process for assaying free hemoglobin and reagent kit for assaying free hemoglobin |
| JPH11201969A (ja) * | 1998-01-14 | 1999-07-30 | Wakamoto Pharmaceut Co Ltd | 簡易遊離ヘモグロビン測定方法および測定用キット |
| JP2010014586A (ja) * | 2008-07-04 | 2010-01-21 | Wako Pure Chem Ind Ltd | 便検体中ヘモグロビンの測定方法及び測定試薬キット |
| EP3467498A1 (en) * | 2016-05-30 | 2019-04-10 | Eiken Kagaku Kabushiki Kaisha | Anti-human hemoglobin monoclonal antibody or antibody kit, insoluble carrier particle to which anti-human hemoglobin monoclonal antibody is immobilized, and measurement reagent and measurement method using same |
| TW201932838A (zh) * | 2017-12-01 | 2019-08-16 | 日商榮研化學股份有限公司 | 將血紅素與血紅素結合球蛋白之複合體安定化之方法、及用以保存含有血紅素之檢體之保存溶液 |
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| AU2019350257A1 (en) | 2021-04-01 |
| EP3859338B1 (en) | 2024-07-24 |
| JP2024107496A (ja) | 2024-08-08 |
| TW202020455A (zh) | 2020-06-01 |
| KR20210064272A (ko) | 2021-06-02 |
| JP7508494B2 (ja) | 2024-07-01 |
| US12405277B2 (en) | 2025-09-02 |
| ES2987836T3 (es) | 2024-11-18 |
| JPWO2020066722A1 (ja) | 2021-09-16 |
| EP3859338A4 (en) | 2022-06-08 |
| US20220043008A1 (en) | 2022-02-10 |
| AU2019350257B2 (en) | 2025-10-23 |
| JP7784481B2 (ja) | 2025-12-11 |
| JP2022033286A (ja) | 2022-02-28 |
| KR102839014B1 (ko) | 2025-07-25 |
| JP7005785B2 (ja) | 2022-02-10 |
| EP3859338A1 (en) | 2021-08-04 |
| SG11202102265UA (en) | 2021-04-29 |
| CN112752974A (zh) | 2021-05-04 |
| WO2020066722A1 (ja) | 2020-04-02 |
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