TWI831780B - 嘧啶衍生物之醫藥鹽及治療病症之方法 - Google Patents

嘧啶衍生物之醫藥鹽及治療病症之方法 Download PDF

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TWI831780B
TWI831780B TW108116512A TW108116512A TWI831780B TW I831780 B TWI831780 B TW I831780B TW 108116512 A TW108116512 A TW 108116512A TW 108116512 A TW108116512 A TW 108116512A TW I831780 B TWI831780 B TW I831780B
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compound
salt
succinate
crystalline form
pharmaceutically acceptable
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TW108116512A
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Chinese (zh)
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TW202015687A (zh
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蘭登 Ｊ 杜拉
瑪莉恩 蘭斯登
普來廸 庫瑪 雪爾瑪
太義 阮
雙蓮 李
曉功 張
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日商武田藥品工業股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW108116512A 2018-05-14 2019-05-14 嘧啶衍生物之醫藥鹽及治療病症之方法 TWI831780B (zh)

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US201862671166P 2018-05-14 2018-05-14
US201862671182P 2018-05-14 2018-05-14
US62/671,166 2018-05-14
US62/671,182 2018-05-14

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TW202015687A TW202015687A (zh) 2020-05-01
TWI831780B true TWI831780B (zh) 2024-02-11

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US (1) US12084431B2 (https=)
EP (2) EP3793993A4 (https=)
JP (2) JP2021523208A (https=)
KR (1) KR20200144579A (https=)
CN (1) CN112313223A (https=)
AU (1) AU2019269372A1 (https=)
BR (1) BR112020023107A2 (https=)
CA (1) CA3099737A1 (https=)
MX (1) MX2020012063A (https=)
TW (1) TWI831780B (https=)
WO (1) WO2019222093A1 (https=)

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US20220340547A1 (en) * 2019-05-22 2022-10-27 Shanghi Hansoh Biosoh Biomedical Co., Ltd. Indole derivative-containing inhibitor, preparation method therefor and application thereof
CN111303125A (zh) * 2020-04-10 2020-06-19 天津法莫西医药科技有限公司 一种甲氧基取代吲哚-嘧啶类化合物及其制备方法
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
WO2023277172A1 (en) 2021-06-30 2023-01-05 Takeda Pharmaceutical Company Limited Process for preparing pharmaceutical salts of pyrimidine derivatives
EP4367116A4 (en) * 2021-07-07 2025-04-30 Crimson Biopharm Inc. Crystalline polymorphs of epidermal growth factor receptor inhibition, and compositions and methods therefor
JP7734995B2 (ja) * 2021-08-06 2025-09-08 上海和誉生物医薬科技有限公司 ピリミジンまたはピリジン誘導体およびその製造方法ならびに薬学上の応用

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CA3099737A1 (en) 2019-11-21
EP3793993A1 (en) 2021-03-24
JP2024051160A (ja) 2024-04-10
KR20200144579A (ko) 2020-12-29
TW202015687A (zh) 2020-05-01
WO2019222093A1 (en) 2019-11-21
AU2019269372A1 (en) 2020-11-26
US12084431B2 (en) 2024-09-10
CN112313223A (zh) 2021-02-02
EP3793993A4 (en) 2022-01-05
BR112020023107A2 (pt) 2021-02-02
JP2021523208A (ja) 2021-09-02
MX2020012063A (es) 2021-04-13
EP4234547A3 (en) 2023-11-01
EP4234547A2 (en) 2023-08-30
US20210309640A1 (en) 2021-10-07

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