CA3099737A1 - Pharmaceutical salts of pyrimidine derivatives and method of treating disorders - Google Patents

Pharmaceutical salts of pyrimidine derivatives and method of treating disorders Download PDF

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Publication number
CA3099737A1
CA3099737A1 CA3099737A CA3099737A CA3099737A1 CA 3099737 A1 CA3099737 A1 CA 3099737A1 CA 3099737 A CA3099737 A CA 3099737A CA 3099737 A CA3099737 A CA 3099737A CA 3099737 A1 CA3099737 A1 CA 3099737A1
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CA
Canada
Prior art keywords
compound
int
methyl
salt
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3099737A
Other languages
English (en)
French (fr)
Inventor
Landon J. DURAK
Marianne Langston
Pradeep Kumar Sharma
Thai Hiep Nguyen
Shuanglian LI
Xiaoguang Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Ariad Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ariad Pharmaceuticals Inc filed Critical Ariad Pharmaceuticals Inc
Publication of CA3099737A1 publication Critical patent/CA3099737A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA3099737A 2018-05-14 2019-05-13 Pharmaceutical salts of pyrimidine derivatives and method of treating disorders Pending CA3099737A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862671166P 2018-05-14 2018-05-14
US201862671182P 2018-05-14 2018-05-14
US62/671,166 2018-05-14
US62/671,182 2018-05-14
PCT/US2019/032002 WO2019222093A1 (en) 2018-05-14 2019-05-13 Pharmaceutical salts of pyrimidine derivatives and method of treating disorders

Publications (1)

Publication Number Publication Date
CA3099737A1 true CA3099737A1 (en) 2019-11-21

Family

ID=68540756

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3099737A Pending CA3099737A1 (en) 2018-05-14 2019-05-13 Pharmaceutical salts of pyrimidine derivatives and method of treating disorders

Country Status (11)

Country Link
US (1) US12084431B2 (https=)
EP (2) EP3793993A4 (https=)
JP (2) JP2021523208A (https=)
KR (1) KR20200144579A (https=)
CN (1) CN112313223A (https=)
AU (1) AU2019269372A1 (https=)
BR (1) BR112020023107A2 (https=)
CA (1) CA3099737A1 (https=)
MX (1) MX2020012063A (https=)
TW (1) TWI831780B (https=)
WO (1) WO2019222093A1 (https=)

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US20220340547A1 (en) * 2019-05-22 2022-10-27 Shanghi Hansoh Biosoh Biomedical Co., Ltd. Indole derivative-containing inhibitor, preparation method therefor and application thereof
CN111303125A (zh) * 2020-04-10 2020-06-19 天津法莫西医药科技有限公司 一种甲氧基取代吲哚-嘧啶类化合物及其制备方法
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
WO2023277172A1 (en) 2021-06-30 2023-01-05 Takeda Pharmaceutical Company Limited Process for preparing pharmaceutical salts of pyrimidine derivatives
EP4367116A4 (en) * 2021-07-07 2025-04-30 Crimson Biopharm Inc. Crystalline polymorphs of epidermal growth factor receptor inhibition, and compositions and methods therefor
JP7734995B2 (ja) * 2021-08-06 2025-09-08 上海和誉生物医薬科技有限公司 ピリミジンまたはピリジン誘導体およびその製造方法ならびに薬学上の応用

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Also Published As

Publication number Publication date
EP3793993A1 (en) 2021-03-24
TWI831780B (zh) 2024-02-11
JP2024051160A (ja) 2024-04-10
KR20200144579A (ko) 2020-12-29
TW202015687A (zh) 2020-05-01
WO2019222093A1 (en) 2019-11-21
AU2019269372A1 (en) 2020-11-26
US12084431B2 (en) 2024-09-10
CN112313223A (zh) 2021-02-02
EP3793993A4 (en) 2022-01-05
BR112020023107A2 (pt) 2021-02-02
JP2021523208A (ja) 2021-09-02
MX2020012063A (es) 2021-04-13
EP4234547A3 (en) 2023-11-01
EP4234547A2 (en) 2023-08-30
US20210309640A1 (en) 2021-10-07

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