TWI786887B - 抗微生物肽及其使用方法 - Google Patents

抗微生物肽及其使用方法 Download PDF

Info

Publication number
TWI786887B
TWI786887B TW110138439A TW110138439A TWI786887B TW I786887 B TWI786887 B TW I786887B TW 110138439 A TW110138439 A TW 110138439A TW 110138439 A TW110138439 A TW 110138439A TW I786887 B TWI786887 B TW I786887B
Authority
TW
Taiwan
Prior art keywords
seq
position corresponding
antimicrobial peptide
animal
arginine
Prior art date
Application number
TW110138439A
Other languages
English (en)
Chinese (zh)
Other versions
TW202204376A (zh
Inventor
克里斯多夫 Ａ 盧克
麥克 昆恩
德瑞克 詹姆士 錫漢
艾瑞克 百瑪
理查 安卓 伊溫
希拉蕊 菲爾斯
Original Assignee
美商碩騰服務有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商碩騰服務有限責任公司 filed Critical 美商碩騰服務有限責任公司
Publication of TW202204376A publication Critical patent/TW202204376A/zh
Application granted granted Critical
Publication of TWI786887B publication Critical patent/TWI786887B/zh

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
TW110138439A 2017-12-07 2018-11-28 抗微生物肽及其使用方法 TWI786887B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762595725P 2017-12-07 2017-12-07
US62/595,725 2017-12-07

Publications (2)

Publication Number Publication Date
TW202204376A TW202204376A (zh) 2022-02-01
TWI786887B true TWI786887B (zh) 2022-12-11

Family

ID=65003464

Family Applications (2)

Application Number Title Priority Date Filing Date
TW110138439A TWI786887B (zh) 2017-12-07 2018-11-28 抗微生物肽及其使用方法
TW107142356A TWI746908B (zh) 2017-12-07 2018-11-28 抗微生物肽及其使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW107142356A TWI746908B (zh) 2017-12-07 2018-11-28 抗微生物肽及其使用方法

Country Status (27)

Country Link
US (3) US11352396B2 (https=)
EP (2) EP4656726A3 (https=)
JP (1) JP7381465B2 (https=)
KR (3) KR102555177B1 (https=)
CN (1) CN111479824A (https=)
AR (1) AR113618A1 (https=)
AU (3) AU2018378035B2 (https=)
BR (1) BR112020009973A2 (https=)
CA (1) CA3082491A1 (https=)
CL (1) CL2020001464A1 (https=)
CO (1) CO2020006907A2 (https=)
DK (1) DK3720875T3 (https=)
ES (1) ES3041688T3 (https=)
FI (1) FI3720875T3 (https=)
HU (1) HUE072916T2 (https=)
IL (2) IL275074B2 (https=)
LT (1) LT3720875T (https=)
MX (1) MX2020005920A (https=)
NZ (1) NZ764838A (https=)
PH (1) PH12020550942A1 (https=)
PL (1) PL3720875T3 (https=)
PT (1) PT3720875T (https=)
SG (1) SG11202004661QA (https=)
SI (1) SI3720875T1 (https=)
TW (2) TWI786887B (https=)
WO (1) WO2019113181A1 (https=)
ZA (1) ZA202003387B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220307048A1 (en) * 2021-03-23 2022-09-29 Genvor Inc. Antimicrobial peptides
CN113185576B (zh) * 2021-04-09 2023-05-30 倪京满 一类具有RRRF转角的β-发卡型低毒广谱抗菌肽及其应用
US20250042946A1 (en) 2021-12-08 2025-02-06 Oakgrove Bio Llc Biological Production of Histidine-Rich Peptides
EP4198045A1 (en) * 2021-12-16 2023-06-21 Université de Lille Antimicrobial peptides, variants and chemical analogues thereof and their uses
WO2024003890A1 (en) * 2022-06-29 2024-01-04 Omnix Medical Ltd. Novel peptide for treating an infectious disease or condition
CN120309697B (zh) * 2025-06-13 2025-09-02 四川大学 一种用于抗革兰氏阴性菌的多肽药物及应用
CN121378418B (zh) * 2025-12-26 2026-04-03 四川大学 一组针对革兰氏阴性菌的抗菌多肽

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104988170A (zh) * 2015-08-01 2015-10-21 吉林农业大学 一种融合抗菌肽及其制备方法和应用
WO2016026354A1 (zh) * 2014-08-21 2016-02-25 天津兰瑞生物技术有限公司 一种鲎素肽-抗体融合蛋白及制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1323166C (zh) * 2003-09-18 2007-06-27 中国农业科学院饲料研究所 一种鲎素的基因及表达其的方法
CN101307316B (zh) * 2008-07-22 2011-03-16 北京中农颖泰生物技术有限公司 抗菌肽cad在枯草杆菌中的分泌表达及重组枯草杆菌表达系统
CN101698682B (zh) * 2009-10-26 2012-05-23 陕西省微生物研究所 一种基于抗菌肽的双功能融合蛋白及其制备方法和用途
CN101817883B (zh) * 2010-03-12 2012-06-13 广东药学院 一种家蝇天蚕素-人溶菌酶融合蛋白及其制备方法和应用
CN101851620B (zh) * 2010-04-21 2012-05-23 吉林农业大学 利用食药用菌生产FGFs的方法
CA2890357C (en) * 2011-07-13 2024-01-09 Solarvest BioEnergy Inc. Methods and uses of a modified cecropin for treating endoparasitic and bacterial infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016026354A1 (zh) * 2014-08-21 2016-02-25 天津兰瑞生物技术有限公司 一种鲎素肽-抗体融合蛋白及制备方法
CN104988170A (zh) * 2015-08-01 2015-10-21 吉林农业大学 一种融合抗菌肽及其制备方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Nakamura T et al. "Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure" JOURNAL OF BIOLOGICAL CHEMISTRY Vol.263, No.32 Elsevier 1988/11/15 P.16709-16713 *

Also Published As

Publication number Publication date
TWI746908B (zh) 2021-11-21
PH12020550942A1 (en) 2021-05-10
US20200385429A1 (en) 2020-12-10
ES3041688T3 (en) 2025-11-13
US20250074947A1 (en) 2025-03-06
EP3720875A1 (en) 2020-10-14
BR112020009973A2 (pt) 2020-11-03
CL2020001464A1 (es) 2020-11-06
PT3720875T (pt) 2025-09-18
SI3720875T1 (sl) 2025-11-28
TW202116348A (zh) 2021-05-01
KR20240151857A (ko) 2024-10-18
CO2020006907A2 (es) 2020-06-19
EP4656726A2 (en) 2025-12-03
AU2023229465B2 (en) 2024-06-13
TW201924712A (zh) 2019-07-01
FI3720875T3 (fi) 2025-09-12
HUE072916T2 (hu) 2025-12-28
US11352396B2 (en) 2022-06-07
NZ764838A (en) 2023-07-28
JP2021505624A (ja) 2021-02-18
CN111479824A (zh) 2020-07-31
AU2018378035B2 (en) 2023-06-15
IL275074A (en) 2020-07-30
KR102555177B1 (ko) 2023-07-12
TW202204376A (zh) 2022-02-01
ZA202003387B (en) 2023-01-25
CA3082491A1 (en) 2019-06-13
AU2024219645A1 (en) 2024-10-03
PL3720875T3 (pl) 2025-10-20
AR113618A1 (es) 2020-05-20
EP3720875B1 (en) 2025-07-16
RU2020118460A (ru) 2022-01-10
IL312730A (en) 2024-07-01
AU2023229465A1 (en) 2023-09-28
JP7381465B2 (ja) 2023-11-15
RU2020118460A3 (https=) 2022-01-10
KR20230110822A (ko) 2023-07-25
KR102713813B1 (ko) 2024-10-11
IL275074B1 (en) 2024-06-01
US20230077604A1 (en) 2023-03-16
LT3720875T (lt) 2025-08-25
AU2018378035A1 (en) 2020-05-28
SG11202004661QA (en) 2020-06-29
WO2019113181A1 (en) 2019-06-13
MX2020005920A (es) 2020-08-20
DK3720875T3 (da) 2025-09-01
US12054518B2 (en) 2024-08-06
KR20200074212A (ko) 2020-06-24
IL275074B2 (en) 2024-10-01
EP4656726A3 (en) 2025-12-31

Similar Documents

Publication Publication Date Title
TWI786887B (zh) 抗微生物肽及其使用方法
JP6964577B2 (ja) 抗菌性ペプチド及びその使用方法
US20190142850A1 (en) Minocycline compounds and methods of use thereof
JP5140579B2 (ja) 病原菌に対する生体防御を増強するヒアルロン酸結合性ペプチド
TWI914311B (zh) 抗微生物肽及其使用方法
RU2783957C2 (ru) Антимикробные пептиды и способы их использования
TWI577697B (zh) 耐高鹽及抗蛋白之抗菌胜肽及其製造方法
JP2018500283A (ja) 環状抗微生物性擬ペプチド及びその使用
HK40029791B (en) Antimicrobial peptides and methods of using same
HK40029791A (en) Antimicrobial peptides and methods of using same
NZ795498A (en) Antimicrobial peptides and methods of using same
CN120380010A (zh) 由跨膜肽结构域及其两末端的碱性或极性氨基酸组成的抗菌肽及其变体
JP2005532784A (ja) 新規の抗菌ボリシンペプチド