CN111479824A - 抗微生物肽及其使用方法 - Google Patents

抗微生物肽及其使用方法 Download PDF

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Publication number
CN111479824A
CN111479824A CN201880078731.4A CN201880078731A CN111479824A CN 111479824 A CN111479824 A CN 111479824A CN 201880078731 A CN201880078731 A CN 201880078731A CN 111479824 A CN111479824 A CN 111479824A
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China
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seq
amino acid
acid sequence
arginine
position corresponding
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Pending
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CN201880078731.4A
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English (en)
Chinese (zh)
Inventor
M·库恩
R·A·埃温
D·J·希恩
E·拜马
C·A·祖克
H·菲尔普斯
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Zoetis Services LLC
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Zoetis Services LLC
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Publication of CN111479824A publication Critical patent/CN111479824A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
CN201880078731.4A 2017-12-07 2018-12-05 抗微生物肽及其使用方法 Pending CN111479824A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762595725P 2017-12-07 2017-12-07
US62/595,725 2017-12-07
PCT/US2018/064029 WO2019113181A1 (en) 2017-12-07 2018-12-05 Antimicrobial peptides and methods of using same

Publications (1)

Publication Number Publication Date
CN111479824A true CN111479824A (zh) 2020-07-31

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ID=65003464

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880078731.4A Pending CN111479824A (zh) 2017-12-07 2018-12-05 抗微生物肽及其使用方法

Country Status (27)

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US (3) US11352396B2 (https=)
EP (2) EP4656726A3 (https=)
JP (1) JP7381465B2 (https=)
KR (3) KR102555177B1 (https=)
CN (1) CN111479824A (https=)
AR (1) AR113618A1 (https=)
AU (3) AU2018378035B2 (https=)
BR (1) BR112020009973A2 (https=)
CA (1) CA3082491A1 (https=)
CL (1) CL2020001464A1 (https=)
CO (1) CO2020006907A2 (https=)
DK (1) DK3720875T3 (https=)
ES (1) ES3041688T3 (https=)
FI (1) FI3720875T3 (https=)
HU (1) HUE072916T2 (https=)
IL (2) IL275074B2 (https=)
LT (1) LT3720875T (https=)
MX (1) MX2020005920A (https=)
NZ (1) NZ764838A (https=)
PH (1) PH12020550942A1 (https=)
PL (1) PL3720875T3 (https=)
PT (1) PT3720875T (https=)
SG (1) SG11202004661QA (https=)
SI (1) SI3720875T1 (https=)
TW (2) TWI786887B (https=)
WO (1) WO2019113181A1 (https=)
ZA (1) ZA202003387B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113185576A (zh) * 2021-04-09 2021-07-30 倪京满 一类具有RRRF转角的β-发卡型低毒广谱抗菌肽及其应用
CN121378418A (zh) * 2025-12-26 2026-01-23 四川大学 一组针对革兰氏阴性菌的抗菌多肽

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220307048A1 (en) * 2021-03-23 2022-09-29 Genvor Inc. Antimicrobial peptides
US20250042946A1 (en) 2021-12-08 2025-02-06 Oakgrove Bio Llc Biological Production of Histidine-Rich Peptides
EP4198045A1 (en) * 2021-12-16 2023-06-21 Université de Lille Antimicrobial peptides, variants and chemical analogues thereof and their uses
WO2024003890A1 (en) * 2022-06-29 2024-01-04 Omnix Medical Ltd. Novel peptide for treating an infectious disease or condition
CN120309697B (zh) * 2025-06-13 2025-09-02 四川大学 一种用于抗革兰氏阴性菌的多肽药物及应用

Citations (3)

* Cited by examiner, † Cited by third party
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CN1597691A (zh) * 2003-09-18 2005-03-23 中国农业科学院饲料研究所 一种抗菌活性更高的改良鲎素的基因及高效表达的方法
CN104988170A (zh) * 2015-08-01 2015-10-21 吉林农业大学 一种融合抗菌肽及其制备方法和应用
WO2016026354A1 (zh) * 2014-08-21 2016-02-25 天津兰瑞生物技术有限公司 一种鲎素肽-抗体融合蛋白及制备方法

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CN101307316B (zh) * 2008-07-22 2011-03-16 北京中农颖泰生物技术有限公司 抗菌肽cad在枯草杆菌中的分泌表达及重组枯草杆菌表达系统
CN101698682B (zh) * 2009-10-26 2012-05-23 陕西省微生物研究所 一种基于抗菌肽的双功能融合蛋白及其制备方法和用途
CN101817883B (zh) * 2010-03-12 2012-06-13 广东药学院 一种家蝇天蚕素-人溶菌酶融合蛋白及其制备方法和应用
CN101851620B (zh) * 2010-04-21 2012-05-23 吉林农业大学 利用食药用菌生产FGFs的方法
CA2890357C (en) * 2011-07-13 2024-01-09 Solarvest BioEnergy Inc. Methods and uses of a modified cecropin for treating endoparasitic and bacterial infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1597691A (zh) * 2003-09-18 2005-03-23 中国农业科学院饲料研究所 一种抗菌活性更高的改良鲎素的基因及高效表达的方法
WO2016026354A1 (zh) * 2014-08-21 2016-02-25 天津兰瑞生物技术有限公司 一种鲎素肽-抗体融合蛋白及制备方法
CN104988170A (zh) * 2015-08-01 2015-10-21 吉林农业大学 一种融合抗菌肽及其制备方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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谢海伟 等: "鲎素抗菌肽的研究进展及应用前景" *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113185576A (zh) * 2021-04-09 2021-07-30 倪京满 一类具有RRRF转角的β-发卡型低毒广谱抗菌肽及其应用
CN113185576B (zh) * 2021-04-09 2023-05-30 倪京满 一类具有RRRF转角的β-发卡型低毒广谱抗菌肽及其应用
CN121378418A (zh) * 2025-12-26 2026-01-23 四川大学 一组针对革兰氏阴性菌的抗菌多肽
CN121378418B (zh) * 2025-12-26 2026-04-03 四川大学 一组针对革兰氏阴性菌的抗菌多肽

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TWI746908B (zh) 2021-11-21
PH12020550942A1 (en) 2021-05-10
US20200385429A1 (en) 2020-12-10
ES3041688T3 (en) 2025-11-13
US20250074947A1 (en) 2025-03-06
EP3720875A1 (en) 2020-10-14
BR112020009973A2 (pt) 2020-11-03
CL2020001464A1 (es) 2020-11-06
PT3720875T (pt) 2025-09-18
SI3720875T1 (sl) 2025-11-28
TW202116348A (zh) 2021-05-01
KR20240151857A (ko) 2024-10-18
CO2020006907A2 (es) 2020-06-19
EP4656726A2 (en) 2025-12-03
AU2023229465B2 (en) 2024-06-13
TW201924712A (zh) 2019-07-01
FI3720875T3 (fi) 2025-09-12
HUE072916T2 (hu) 2025-12-28
US11352396B2 (en) 2022-06-07
NZ764838A (en) 2023-07-28
JP2021505624A (ja) 2021-02-18
AU2018378035B2 (en) 2023-06-15
IL275074A (en) 2020-07-30
KR102555177B1 (ko) 2023-07-12
TWI786887B (zh) 2022-12-11
TW202204376A (zh) 2022-02-01
ZA202003387B (en) 2023-01-25
CA3082491A1 (en) 2019-06-13
AU2024219645A1 (en) 2024-10-03
PL3720875T3 (pl) 2025-10-20
AR113618A1 (es) 2020-05-20
EP3720875B1 (en) 2025-07-16
RU2020118460A (ru) 2022-01-10
IL312730A (en) 2024-07-01
AU2023229465A1 (en) 2023-09-28
JP7381465B2 (ja) 2023-11-15
RU2020118460A3 (https=) 2022-01-10
KR20230110822A (ko) 2023-07-25
KR102713813B1 (ko) 2024-10-11
IL275074B1 (en) 2024-06-01
US20230077604A1 (en) 2023-03-16
LT3720875T (lt) 2025-08-25
AU2018378035A1 (en) 2020-05-28
SG11202004661QA (en) 2020-06-29
WO2019113181A1 (en) 2019-06-13
MX2020005920A (es) 2020-08-20
DK3720875T3 (da) 2025-09-01
US12054518B2 (en) 2024-08-06
KR20200074212A (ko) 2020-06-24
IL275074B2 (en) 2024-10-01
EP4656726A3 (en) 2025-12-31

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