TWI746908B - 抗微生物肽及其使用方法 - Google Patents

抗微生物肽及其使用方法 Download PDF

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Publication number
TWI746908B
TWI746908B TW107142356A TW107142356A TWI746908B TW I746908 B TWI746908 B TW I746908B TW 107142356 A TW107142356 A TW 107142356A TW 107142356 A TW107142356 A TW 107142356A TW I746908 B TWI746908 B TW I746908B
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TW
Taiwan
Prior art keywords
seq
artificial
prt
antimicrobial peptide
artificial sequence
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TW107142356A
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English (en)
Chinese (zh)
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TW201924712A (zh
Inventor
克里斯多夫 A 盧克
麥克 昆恩
德瑞克 詹姆士 錫漢
艾瑞克 百瑪
理查 安卓 伊溫
希拉蕊 菲爾斯
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美商碩騰服務有限責任公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43509Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46N-acyl derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8281Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
TW107142356A 2017-12-07 2018-11-28 抗微生物肽及其使用方法 TWI746908B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762595725P 2017-12-07 2017-12-07
US62/595,725 2017-12-07

Publications (2)

Publication Number Publication Date
TW201924712A TW201924712A (zh) 2019-07-01
TWI746908B true TWI746908B (zh) 2021-11-21

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TW110138439A TWI786887B (zh) 2017-12-07 2018-11-28 抗微生物肽及其使用方法

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US (3) US11352396B2 (https=)
EP (2) EP4656726A3 (https=)
JP (1) JP7381465B2 (https=)
KR (3) KR102713813B1 (https=)
CN (1) CN111479824A (https=)
AR (1) AR113618A1 (https=)
AU (3) AU2018378035B2 (https=)
BR (1) BR112020009973A2 (https=)
CA (1) CA3082491A1 (https=)
CL (1) CL2020001464A1 (https=)
CO (1) CO2020006907A2 (https=)
DK (1) DK3720875T3 (https=)
ES (1) ES3041688T3 (https=)
FI (1) FI3720875T3 (https=)
HU (1) HUE072916T2 (https=)
IL (2) IL312730A (https=)
LT (1) LT3720875T (https=)
MX (1) MX2020005920A (https=)
NZ (1) NZ764838A (https=)
PH (1) PH12020550942A1 (https=)
PL (1) PL3720875T3 (https=)
PT (1) PT3720875T (https=)
SG (1) SG11202004661QA (https=)
SI (1) SI3720875T1 (https=)
TW (2) TWI746908B (https=)
WO (1) WO2019113181A1 (https=)
ZA (1) ZA202003387B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112023019519A2 (pt) * 2021-03-23 2023-10-31 Genvor Inc Peptídeos antimicrobianos
CN113185576B (zh) * 2021-04-09 2023-05-30 倪京满 一类具有RRRF转角的β-发卡型低毒广谱抗菌肽及其应用
US20250042946A1 (en) 2021-12-08 2025-02-06 Oakgrove Bio Llc Biological Production of Histidine-Rich Peptides
EP4198045A1 (en) * 2021-12-16 2023-06-21 Université de Lille Antimicrobial peptides, variants and chemical analogues thereof and their uses
EP4547696A4 (en) * 2022-06-29 2025-10-22 Omnix Medical Ltd NEW PEPTIDE FOR THE TREATMENT OF AN INFECTIOUS DISEASE OR CONDITION
CN120309697B (zh) * 2025-06-13 2025-09-02 四川大学 一种用于抗革兰氏阴性菌的多肽药物及应用
CN121378418B (zh) * 2025-12-26 2026-04-03 四川大学 一组针对革兰氏阴性菌的抗菌多肽

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104988170A (zh) * 2015-08-01 2015-10-21 吉林农业大学 一种融合抗菌肽及其制备方法和应用
WO2016026354A1 (zh) * 2014-08-21 2016-02-25 天津兰瑞生物技术有限公司 一种鲎素肽-抗体融合蛋白及制备方法

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CN1323166C (zh) * 2003-09-18 2007-06-27 中国农业科学院饲料研究所 一种鲎素的基因及表达其的方法
CN101307316B (zh) 2008-07-22 2011-03-16 北京中农颖泰生物技术有限公司 抗菌肽cad在枯草杆菌中的分泌表达及重组枯草杆菌表达系统
CN101698682B (zh) 2009-10-26 2012-05-23 陕西省微生物研究所 一种基于抗菌肽的双功能融合蛋白及其制备方法和用途
CN101817883B (zh) 2010-03-12 2012-06-13 广东药学院 一种家蝇天蚕素-人溶菌酶融合蛋白及其制备方法和应用
CN101851620B (zh) 2010-04-21 2012-05-23 吉林农业大学 利用食药用菌生产FGFs的方法
WO2013006956A1 (en) 2011-07-13 2013-01-17 Phyterra Bio Inc. Methods and uses of a modified cecropin for treating endoparasitic and bacterial infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016026354A1 (zh) * 2014-08-21 2016-02-25 天津兰瑞生物技术有限公司 一种鲎素肽-抗体融合蛋白及制备方法
CN104988170A (zh) * 2015-08-01 2015-10-21 吉林农业大学 一种融合抗菌肽及其制备方法和应用

Non-Patent Citations (1)

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Title
ISOLATION AND CHEMICAL STRUCTURE,"Tachyplesin, a Class of AntimicrobiaPl eptide from the Hemocytes of the Horseshoe Crab (Tach ypleus tridentatus)" THEJ OURNAL OF BIOLOGICACLH EMISTRY Vol. 263, No. 32, 1988, pp. 16709-16713,1988 *

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WO2019113181A1 (en) 2019-06-13
PL3720875T3 (pl) 2025-10-20
RU2020118460A3 (https=) 2022-01-10
US12054518B2 (en) 2024-08-06
TW202204376A (zh) 2022-02-01
US20250074947A1 (en) 2025-03-06
NZ764838A (en) 2023-07-28
US11352396B2 (en) 2022-06-07
PH12020550942A1 (en) 2021-05-10
JP7381465B2 (ja) 2023-11-15
ES3041688T3 (en) 2025-11-13
KR102555177B1 (ko) 2023-07-12
HUE072916T2 (hu) 2025-12-28
US20200385429A1 (en) 2020-12-10
IL312730A (en) 2024-07-01
CA3082491A1 (en) 2019-06-13
SG11202004661QA (en) 2020-06-29
EP4656726A2 (en) 2025-12-03
US20230077604A1 (en) 2023-03-16
EP3720875A1 (en) 2020-10-14
EP4656726A3 (en) 2025-12-31
CO2020006907A2 (es) 2020-06-19
KR20200074212A (ko) 2020-06-24
SI3720875T1 (sl) 2025-11-28
CL2020001464A1 (es) 2020-11-06
FI3720875T3 (fi) 2025-09-12
TW201924712A (zh) 2019-07-01
ZA202003387B (en) 2023-01-25
PT3720875T (pt) 2025-09-18
AR113618A1 (es) 2020-05-20
EP3720875B1 (en) 2025-07-16
AU2023229465B2 (en) 2024-06-13
IL275074A (en) 2020-07-30
BR112020009973A2 (pt) 2020-11-03
MX2020005920A (es) 2020-08-20
DK3720875T3 (da) 2025-09-01
AU2023229465A1 (en) 2023-09-28
TWI786887B (zh) 2022-12-11
KR102713813B1 (ko) 2024-10-11
IL275074B1 (en) 2024-06-01
JP2021505624A (ja) 2021-02-18
CN111479824A (zh) 2020-07-31
AU2018378035B2 (en) 2023-06-15
IL275074B2 (en) 2024-10-01
RU2020118460A (ru) 2022-01-10
LT3720875T (lt) 2025-08-25
AU2024219645A1 (en) 2024-10-03
KR20230110822A (ko) 2023-07-25
AU2018378035A1 (en) 2020-05-28
TW202116348A (zh) 2021-05-01
KR20240151857A (ko) 2024-10-18

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