TWI774694B - 具有降低對胰島素受體之親和力之胰島素類似物及其用途 - Google Patents
具有降低對胰島素受體之親和力之胰島素類似物及其用途 Download PDFInfo
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- TWI774694B TWI774694B TW106132612A TW106132612A TWI774694B TW I774694 B TWI774694 B TW I774694B TW 106132612 A TW106132612 A TW 106132612A TW 106132612 A TW106132612 A TW 106132612A TW I774694 B TWI774694 B TW I774694B
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- insulin
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160122484 | 2016-09-23 | ||
| ??10-2016-0122484 | 2016-09-23 | ||
| KR10-2016-0122484 | 2016-09-23 |
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| TW201813977A TW201813977A (zh) | 2018-04-16 |
| TWI774694B true TWI774694B (zh) | 2022-08-21 |
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| TW106132612A TWI774694B (zh) | 2016-09-23 | 2017-09-22 | 具有降低對胰島素受體之親和力之胰島素類似物及其用途 |
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| Country | Link |
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| US (1) | US11396534B2 (https=) |
| EP (1) | EP3517544B1 (https=) |
| JP (1) | JP7158378B2 (https=) |
| KR (1) | KR102698929B1 (https=) |
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| KR102629006B1 (ko) * | 2017-03-23 | 2024-01-25 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도 |
| KR20210029210A (ko) | 2018-06-29 | 2021-03-15 | 악스톤 바이오사이언시스 코퍼레이션 | 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| KR20210102347A (ko) | 2018-12-11 | 2021-08-19 | 사노피 | 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체 |
| KR20250142943A (ko) | 2019-12-19 | 2025-09-30 | 악스톤 바이오사이언시스 코퍼레이션 | 초-장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| LT3972987T (lt) | 2020-04-10 | 2023-09-25 | Akston Biosciences Corporation | Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| EP4373861A4 (en) | 2021-07-23 | 2025-08-20 | Akston Biosciences Corp | INSULIN-FC FUSION PROTEINS AND METHODS OF USE FOR TREATING CANCER |
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| WO2016006963A1 (en) * | 2014-07-11 | 2016-01-14 | Hanmi Pharm. Co., Ltd. | Insulin analogue |
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| AU2017332408B2 (en) | 2022-02-10 |
| RU2764197C1 (ru) | 2022-01-14 |
| KR102698929B1 (ko) | 2024-08-27 |
| JP7158378B2 (ja) | 2022-10-21 |
| KR20180033105A (ko) | 2018-04-02 |
| TW201813977A (zh) | 2018-04-16 |
| AR109552A1 (es) | 2018-12-19 |
| WO2018056764A1 (ko) | 2018-03-29 |
| CN110546161A (zh) | 2019-12-06 |
| US11396534B2 (en) | 2022-07-26 |
| JP2019531075A (ja) | 2019-10-31 |
| BR112019005637A2 (pt) | 2019-07-30 |
| CN110546161B (zh) | 2024-01-26 |
| CA3037844A1 (en) | 2018-03-29 |
| US20190300593A1 (en) | 2019-10-03 |
| EP3517544A1 (en) | 2019-07-31 |
| EP3517544A4 (en) | 2020-06-03 |
| EP3517544C0 (en) | 2025-01-08 |
| AU2017332408A1 (en) | 2019-05-16 |
| EP3517544B1 (en) | 2025-01-08 |
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