AR109552A1 - Análogos de insulina con afinidad reducida para el receptor de insulina y uso de los mismos - Google Patents

Análogos de insulina con afinidad reducida para el receptor de insulina y uso de los mismos

Info

Publication number
AR109552A1
AR109552A1 ARP170102640A ARP170102640A AR109552A1 AR 109552 A1 AR109552 A1 AR 109552A1 AR P170102640 A ARP170102640 A AR P170102640A AR P170102640 A ARP170102640 A AR P170102640A AR 109552 A1 AR109552 A1 AR 109552A1
Authority
AR
Argentina
Prior art keywords
insulin
amino acid
chain
receiver
same
Prior art date
Application number
ARP170102640A
Other languages
English (en)
Inventor
Norbert Tennagels
Stefan Guessregen
Marcus Korn
Sung Youb Jung
In Young Choi
Original Assignee
Hanmi Pharm Ind Co Ltd
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd, Sanofi Aventis Deutschland filed Critical Hanmi Pharm Ind Co Ltd
Publication of AR109552A1 publication Critical patent/AR109552A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Reivindicación 1: Un análogo de insulina, que comprende por lo menos una modificación en aminoácidos seleccionados del grupo que consiste en el decimosexto aminoácido de la cadena B, el vigésimo quinto aminoácido de la cadena B, el decimocuarto aminoácido de la cadena A, y el decimonoveno aminoácido de la cadena A de insulina nativa. Reivindicación 16: Un ácido nucleico aislado que codifica el análogo de insulina de acuerdo con cualquiera de las reivindicaciones 1 a 15. Reivindicación 17: Un vector de expresión recombinante que comprende el ácido nucleico de acuerdo con la reivindicación 16. Reivindicación 18: Un transformante que comprende el vector de expresión recombinante de acuerdo con la reivindicación 17. Reivindicación 22: Una composición farmacéutica para el tratamiento de la diabetes que comprende el análogo de insulina de acuerdo con cualquiera de las reivindicaciones 1 a 15 como un componente activo.
ARP170102640A 2016-09-23 2017-09-25 Análogos de insulina con afinidad reducida para el receptor de insulina y uso de los mismos AR109552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20160122484 2016-09-23

Publications (1)

Publication Number Publication Date
AR109552A1 true AR109552A1 (es) 2018-12-19

Family

ID=61690584

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170102640A AR109552A1 (es) 2016-09-23 2017-09-25 Análogos de insulina con afinidad reducida para el receptor de insulina y uso de los mismos

Country Status (12)

Country Link
US (1) US11396534B2 (es)
EP (1) EP3517544A4 (es)
JP (1) JP7158378B2 (es)
KR (1) KR102698929B1 (es)
CN (1) CN110546161B (es)
AR (1) AR109552A1 (es)
AU (1) AU2017332408B2 (es)
BR (1) BR112019005637A2 (es)
CA (1) CA3037844A1 (es)
RU (1) RU2764197C1 (es)
TW (1) TWI774694B (es)
WO (1) WO2018056764A1 (es)

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EP3604328A4 (en) * 2017-03-23 2021-01-06 Hanmi Pharm. Co., Ltd. REDUCED INSULIN ANALOGUE COMPLEX FOR INSULIN RECEPTOR AND ITS USE
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
EP4186920B1 (en) 2018-06-29 2024-01-03 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
BR112021011050A2 (pt) 2018-12-11 2021-08-31 Sanofi Ligante peptídico
EP4073098B1 (en) 2019-12-19 2023-09-27 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
IL297064B1 (en) 2020-04-10 2024-08-01 Akston Biosciences Corp Antigen-specific immunotherapy for covid-19 fusion proteins and methods of use
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
EP4373861A2 (en) 2021-07-23 2024-05-29 Akston Biosciences Corporation Insulin-fc fusion proteins and methods of use to treat cancer

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EP3604328A4 (en) 2017-03-23 2021-01-06 Hanmi Pharm. Co., Ltd. REDUCED INSULIN ANALOGUE COMPLEX FOR INSULIN RECEPTOR AND ITS USE

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