BR112019011860A2 - proteína de fusão insulina-fc, sequência de ácido nucleico recombinante que codifica a mesma, vetor, célula eucariótica modificada, kit e método para tratar ou prevenir o diabetes autoimune - Google Patents
proteína de fusão insulina-fc, sequência de ácido nucleico recombinante que codifica a mesma, vetor, célula eucariótica modificada, kit e método para tratar ou prevenir o diabetes autoimuneInfo
- Publication number
- BR112019011860A2 BR112019011860A2 BR112019011860A BR112019011860A BR112019011860A2 BR 112019011860 A2 BR112019011860 A2 BR 112019011860A2 BR 112019011860 A BR112019011860 A BR 112019011860A BR 112019011860 A BR112019011860 A BR 112019011860A BR 112019011860 A2 BR112019011860 A2 BR 112019011860A2
- Authority
- BR
- Brazil
- Prior art keywords
- insulin
- fusion protein
- kit
- vector
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
a presente divulgação diz respeito a composições de proteínas de fusão insulina-fc (por exemplo, proinsulina-fc) e ao uso destas para tratar doenças autoimunes, por exemplo, o diabetes autoimune, por exemplo, diabetes tipo 1.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662432268P | 2016-12-09 | 2016-12-09 | |
| US201762514449P | 2017-06-02 | 2017-06-02 | |
| US201762514427P | 2017-06-02 | 2017-06-02 | |
| US201762514460P | 2017-06-02 | 2017-06-02 | |
| PCT/US2017/065456 WO2018107117A1 (en) | 2016-12-09 | 2017-12-08 | Insulin-fc fusions and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019011860A2 true BR112019011860A2 (pt) | 2019-11-12 |
Family
ID=62491387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019011860A BR112019011860A2 (pt) | 2016-12-09 | 2017-12-08 | proteína de fusão insulina-fc, sequência de ácido nucleico recombinante que codifica a mesma, vetor, célula eucariótica modificada, kit e método para tratar ou prevenir o diabetes autoimune |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11359001B2 (pt) |
| EP (2) | EP3939605A1 (pt) |
| JP (2) | JP7170332B2 (pt) |
| CN (1) | CN110612112B (pt) |
| AU (2) | AU2017371217B2 (pt) |
| BR (1) | BR112019011860A2 (pt) |
| CA (1) | CA3046337C (pt) |
| DK (1) | DK3551209T3 (pt) |
| HR (1) | HRP20211334T1 (pt) |
| HU (1) | HUE055417T2 (pt) |
| LT (1) | LT3551209T (pt) |
| SI (1) | SI3551209T1 (pt) |
| WO (1) | WO2018107117A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7170332B2 (ja) | 2016-12-09 | 2022-11-14 | アクストン バイオサイエンシズ コーポレーション | インスリンとｆｃの融合物および使用方法 |
| EP4186920B1 (en) | 2018-06-29 | 2024-01-03 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| WO2021011827A1 (en) * | 2019-07-16 | 2021-01-21 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| HRP20231433T1 (hr) * | 2019-12-19 | 2024-03-29 | Akston Biosciences Corporation | Inzulin-fc fuzijski proteini ultradugog djelovanja i načini uporabe |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| US11213581B2 (en) * | 2020-04-10 | 2022-01-04 | Akston Biosciences Corporation | Antigen specific immunotherapy for COVID-19 fusion proteins and methods of use |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| EP4230216A1 (en) * | 2020-07-24 | 2023-08-23 | Jiangsu Gensciences Inc. | Insulin-fc fusion protein and application thereof |
| US11667689B2 (en) | 2021-07-23 | 2023-06-06 | Akston Biosciences Corporation | Insulin-Fc fusion proteins and methods of use to treat cancer |
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| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| CN1125081C (zh) * | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
| US20030040601A1 (en) * | 2001-06-08 | 2003-02-27 | Ivan Diers | Method for making insulin precursors and insulin analog precursors |
| EP2408470A4 (en) * | 2009-03-20 | 2012-08-29 | Smartcells Inc | SOLUBLE NONDEPOT INSULIN CONJUGATE AND ITS USE |
| CA2754408A1 (en) | 2009-03-30 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Fusion proteins comprising canine fc portions |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| CN101891823B (zh) | 2010-06-11 | 2012-10-03 | 北京东方百泰生物科技有限公司 | 一种Exendin-4及其类似物融合蛋白 |
| WO2012015692A2 (en) * | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| EP2598170A4 (en) | 2010-07-28 | 2016-07-06 | Smartcells Inc | MEDICAMENT-LIGAND CONJUGATES, THEIR SYNTHESIS AND CORRESPONDING INTERMEDIATES |
| EA201400030A1 (ru) * | 2011-06-17 | 2014-07-30 | Галозим, Инк. | Способ непрерывного подкожного введения инсулина с использованием фермента, разрушающего хиалуронан |
| AR087433A1 (es) | 2011-08-08 | 2014-03-26 | Merck Sharp & Dohme | Analogos de insulina n-glicosilados |
| CA2854806A1 (en) | 2011-11-07 | 2013-05-16 | Medimmune, Llc | Multispecific and multivalent binding proteins and uses thereof |
| US20140302028A1 (en) | 2011-11-18 | 2014-10-09 | Merck Sharp & Dohme Corp. | Fc containing polypeptides having increased anti-inflammatory properties and increased fcrn binding |
| KR102041412B1 (ko) | 2011-12-30 | 2019-11-11 | 한미사이언스 주식회사 | 면역글로불린 Ｆｃ 단편 유도체 |
| CN103509118B (zh) * | 2012-06-15 | 2016-03-23 | 郭怀祖 | 胰岛素-Fc融合蛋白 |
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| WO2016193380A1 (en) | 2015-06-02 | 2016-12-08 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
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| JP7170332B2 (ja) | 2016-12-09 | 2022-11-14 | アクストン バイオサイエンシズ コーポレーション | インスリンとｆｃの融合物および使用方法 |
| AR111122A1 (es) | 2017-03-07 | 2019-06-05 | Univ Case Western Reserve | Análogos de insulina de cadena única estabilizados por un cuarto puente disulfuro |
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| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| EP4186920B1 (en) | 2018-06-29 | 2024-01-03 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
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-
2017
- 2017-12-08 JP JP2019551507A patent/JP7170332B2/ja active Active
- 2017-12-08 CN CN201780085106.8A patent/CN110612112B/zh active Active
- 2017-12-08 LT LTEPPCT/US2017/065456T patent/LT3551209T/lt unknown
- 2017-12-08 US US16/468,182 patent/US11359001B2/en active Active
- 2017-12-08 SI SI201730909T patent/SI3551209T1/sl unknown
- 2017-12-08 HU HUE17878116A patent/HUE055417T2/hu unknown
- 2017-12-08 AU AU2017371217A patent/AU2017371217B2/en active Active
- 2017-12-08 WO PCT/US2017/065456 patent/WO2018107117A1/en unknown
- 2017-12-08 CA CA3046337A patent/CA3046337C/en active Active
- 2017-12-08 DK DK17878116.7T patent/DK3551209T3/da active
- 2017-12-08 EP EP21181286.2A patent/EP3939605A1/en active Pending
- 2017-12-08 EP EP17878116.7A patent/EP3551209B1/en active Active
- 2017-12-08 BR BR112019011860A patent/BR112019011860A2/pt unknown
-
2019
- 2019-06-12 US US16/438,681 patent/US10597435B2/en active Active
-
2020
- 2020-08-31 AU AU2020227002A patent/AU2020227002B2/en active Active
-
2021
- 2021-08-19 HR HRP20211334TT patent/HRP20211334T1/hr unknown
-
2022
- 2022-10-25 JP JP2022170351A patent/JP2023017806A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020227002B2 (en) | 2024-02-01 |
| US20190315828A1 (en) | 2019-10-17 |
| EP3939605A1 (en) | 2022-01-19 |
| US20200131243A1 (en) | 2020-04-30 |
| HRP20211334T1 (hr) | 2021-11-26 |
| CA3046337A1 (en) | 2018-06-14 |
| AU2017371217A1 (en) | 2019-07-25 |
| HUE055417T2 (hu) | 2021-11-29 |
| LT3551209T (lt) | 2021-09-10 |
| CA3046337C (en) | 2021-06-01 |
| JP7170332B2 (ja) | 2022-11-14 |
| WO2018107117A1 (en) | 2018-06-14 |
| EP3551209A4 (en) | 2020-06-03 |
| CN110612112B (zh) | 2024-03-29 |
| AU2020227002A1 (en) | 2020-09-17 |
| DK3551209T3 (da) | 2021-08-23 |
| JP2020503889A (ja) | 2020-02-06 |
| EP3551209A1 (en) | 2019-10-16 |
| CN110612112A (zh) | 2019-12-24 |
| US11359001B2 (en) | 2022-06-14 |
| US10597435B2 (en) | 2020-03-24 |
| AU2017371217B2 (en) | 2020-03-19 |
| JP2023017806A (ja) | 2023-02-07 |
| EP3551209B1 (en) | 2021-06-30 |
| SI3551209T1 (sl) | 2021-10-29 |
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