MX346957B - Agonistas de receptor de glp-1/glucagón de acción prolongada. - Google Patents

Agonistas de receptor de glp-1/glucagón de acción prolongada.

Info

Publication number
MX346957B
MX346957B MX2013014069A MX2013014069A MX346957B MX 346957 B MX346957 B MX 346957B MX 2013014069 A MX2013014069 A MX 2013014069A MX 2013014069 A MX2013014069 A MX 2013014069A MX 346957 B MX346957 B MX 346957B
Authority
MX
Mexico
Prior art keywords
receptor agonists
long
glucagon receptor
acting glp
glp
Prior art date
Application number
MX2013014069A
Other languages
English (en)
Other versions
MX2013014069A (es
Inventor
Eyal Fima Udi
Hershkovitz Oren
Original Assignee
Prolor Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolor Biotech Inc filed Critical Prolor Biotech Inc
Publication of MX2013014069A publication Critical patent/MX2013014069A/es
Publication of MX346957B publication Critical patent/MX346957B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere agonistas de receptor de GLP1/Glucagón pegilados y pegilados inversos incluyendo composiciones farmacéuticas comprendiendo los mismos y métodos para usar los mismos.
MX2013014069A 2011-06-02 2012-06-04 Agonistas de receptor de glp-1/glucagón de acción prolongada. MX346957B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161492448P 2011-06-02 2011-06-02
US201261624589P 2012-04-16 2012-04-16
PCT/US2012/040744 WO2012167251A1 (en) 2011-06-02 2012-06-04 Long-acting glp-1/glucagon receptor agonists

Publications (2)

Publication Number Publication Date
MX2013014069A MX2013014069A (es) 2014-08-22
MX346957B true MX346957B (es) 2017-04-06

Family

ID=47259955

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013014069A MX346957B (es) 2011-06-02 2012-06-04 Agonistas de receptor de glp-1/glucagón de acción prolongada.

Country Status (17)

Country Link
US (1) US20140349922A1 (es)
EP (1) EP2714070B1 (es)
JP (1) JP6182134B2 (es)
KR (1) KR102092206B1 (es)
CN (1) CN104023739A (es)
AU (1) AU2012261869B2 (es)
BR (1) BR112013030933A2 (es)
CA (1) CA2837710C (es)
CL (1) CL2013003450A1 (es)
CO (1) CO6980619A2 (es)
EA (1) EA201391764A1 (es)
ES (1) ES2981891T3 (es)
HK (1) HK1201478A1 (es)
IL (1) IL229732B (es)
MX (1) MX346957B (es)
SG (1) SG10201606243YA (es)
WO (1) WO2012167251A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
BR112014025951A2 (pt) 2012-04-19 2017-07-11 Opko Biologics Ltd variantes de oxintomodulina de longa ação e métodos de produção do mesmo
CN109096387B (zh) * 2012-06-04 2021-11-30 奥普科生物制品有限公司 聚乙二醇化的oxm变体
CN112661863A (zh) 2012-11-20 2021-04-16 奥普科生物制品有限公司 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
PE20161153A1 (es) 2014-01-20 2016-10-27 Hanmi Pharm Ind Co Ltd Insulina de accion prolongada y uso de la misma
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
AR100695A1 (es) 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
MX2017015375A (es) * 2015-05-29 2018-06-19 Opko Biologics Ltd Variantes de oxintomodulina pegilada.
EP3310347B1 (en) 2015-06-19 2021-08-04 OPKO Biologics Ltd. Long-acting coagulation factors and methods of producing same
TW201706291A (zh) * 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
EP3368693A4 (en) * 2015-10-30 2019-03-27 The Research Foundation For The State University Of New York University at Buffalo OXYNTOMODULINE ANALOGUES AND METHODS OF PREPARATION AND USE
CN113456820B (zh) * 2015-12-29 2023-09-08 派格生物医药(苏州)股份有限公司 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途
EP3468610A1 (en) * 2016-06-09 2019-04-17 OPKO Biologics Ltd. Long-acting oxyntomodulin formulation and methods of producing and administering same
KR20240006077A (ko) 2016-07-11 2024-01-12 옵코 바이오로직스 리미티드 지속성 응고 인자 vii 및 그 제조 방법
BR112019005637A2 (pt) 2016-09-23 2019-07-30 Hanmi Pharm Ind Co Ltd análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso
CA3054899A1 (en) 2017-03-23 2018-09-27 Hanmi Pharm. Co., Ltd. Insulin analog complex with reduced affinity for insulin receptor and use thereof
US11376345B2 (en) 2017-11-23 2022-07-05 Sentigel Ab Hydrogel composition and its uses
US20200262887A1 (en) * 2018-11-30 2020-08-20 Opko Ireland Global Holdings, Ltd. Oxyntomodulin peptide analog formulations
EP3924369A1 (en) 2019-02-11 2021-12-22 OPKO Biologics Ltd. Long-acting glp-2 analogs
CN117586373A (zh) * 2022-08-10 2024-02-23 成都奥达生物科技有限公司 一种长效双激动剂化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119029A0 (en) 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
CA2521784C (en) 2003-04-08 2012-03-27 Yeda Research And Development Co. Ltd. Reversible pegylated drugs
JP5297817B2 (ja) * 2006-02-22 2013-09-25 メルク・シャープ・アンド・ドーム・コーポレーション オキシントモジュリン誘導体
WO2010033240A2 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
AU2010225523B2 (en) * 2009-03-20 2012-05-24 Hanmi Science Co., Ltd. Method for preparing a site-specific physiologically active polypeptide conjugate
AR079344A1 (es) * 2009-12-22 2012-01-18 Lilly Co Eli Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad

Also Published As

Publication number Publication date
HK1201478A1 (en) 2015-09-04
IL229732B (en) 2021-10-31
KR20140083929A (ko) 2014-07-04
CA2837710C (en) 2022-11-08
MX2013014069A (es) 2014-08-22
IL229732A0 (en) 2014-01-30
KR102092206B1 (ko) 2020-03-24
EP2714070A4 (en) 2015-03-04
CN104023739A (zh) 2014-09-03
AU2012261869B2 (en) 2017-01-05
EP2714070A1 (en) 2014-04-09
EP2714070B1 (en) 2024-03-20
EA201391764A1 (ru) 2014-07-30
JP2014516993A (ja) 2014-07-17
CA2837710A1 (en) 2012-12-06
WO2012167251A1 (en) 2012-12-06
AU2012261869A1 (en) 2014-01-16
CL2013003450A1 (es) 2015-01-16
BR112013030933A2 (pt) 2018-04-24
JP6182134B2 (ja) 2017-08-16
CO6980619A2 (es) 2014-06-27
US20140349922A1 (en) 2014-11-27
SG10201606243YA (en) 2016-09-29
ES2981891T3 (es) 2024-10-11

Similar Documents

Publication Publication Date Title
MX346957B (es) Agonistas de receptor de glp-1/glucagón de acción prolongada.
HRP20181300T1 (hr) Derivati eksendina-4 kao dvostruki glp1/gip- ili trostruki glp1/gip/glukagon agonisti
ZA201804998B (en) Long-acting conjugate of triple glucagon/glp-1/gip receptor agonist
NZ612297A (en) Glucagon analogs exhibiting gip receptor activity
MX2013015168A (es) Co-agonista del receptor de glucagon/glp-1.
MX347703B (es) Co-agonistas del receptor de glucagon/glp-1.
AU2012273365A8 (en) Glucagon/GLP-1 receptor co-agonists
EP2718317A4 (en) GLUCOSE-DEPENDENT INSULINOTROPE POLYPEPTIDE ANALOGUE, PHARMACEUTICAL COMPOSITIONS AND THEIR USE
ZA201501694B (en) Exendin-4 derivatives as dual glp1/glucagon agonists
EP2694095A4 (en) COMPOSITIONS COMPRISING GLUCAGON ANALOGUES AND METHODS OF MAKING AND USING THE SAME
RS60432B1 (sr) Upotreba glp-1 peptida sa dugim dejstvom
EP3377521A4 (en) LONG-ACTING CO AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS
EP3700550A4 (en) LONG-ACTING CO-AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS
HK1201264A1 (en) Long-acting injectable moxidectin formulations and novel moxidectin crystal forms
ME02228B (me) Derivati pikolinamido- propanske kisjelne koji su korisni kao antagonisti receptora glukagona
ZA201209566B (en) Novel glucagon like peptide analogs,composition,and method of use
TN2013000524A1 (en) Glucagon/glp-1 receptor co-agonists
PT2866825T (pt) Uso de péptidos glp-1 de longa ação

Legal Events

Date Code Title Description
FG Grant or registration