BR112019005637A2 - análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso - Google Patents
análogos da insulina com afinidade reduzida para o receptor de insulina e seu usoInfo
- Publication number
- BR112019005637A2 BR112019005637A2 BR112019005637A BR112019005637A BR112019005637A2 BR 112019005637 A2 BR112019005637 A2 BR 112019005637A2 BR 112019005637 A BR112019005637 A BR 112019005637A BR 112019005637 A BR112019005637 A BR 112019005637A BR 112019005637 A2 BR112019005637 A2 BR 112019005637A2
- Authority
- BR
- Brazil
- Prior art keywords
- insulin
- reduced affinity
- analogues
- receptor
- insulin receptor
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 2
- 102000003746 Insulin Receptor Human genes 0.000 title 1
- 108010001127 Insulin Receptor Proteins 0.000 title 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160122484 | 2016-09-23 | ||
| PCT/KR2017/010504 WO2018056764A1 (ko) | 2016-09-23 | 2017-09-22 | 인슐린 수용체와의 결합력이 감소된, 인슐린 아날로그 및 이의 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019005637A2 true BR112019005637A2 (pt) | 2019-07-30 |
Family
ID=61690584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019005637A BR112019005637A2 (pt) | 2016-09-23 | 2017-09-22 | análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11396534B2 (https=) |
| EP (1) | EP3517544B1 (https=) |
| JP (1) | JP7158378B2 (https=) |
| KR (1) | KR102698929B1 (https=) |
| CN (1) | CN110546161B (https=) |
| AR (1) | AR109552A1 (https=) |
| AU (1) | AU2017332408B2 (https=) |
| BR (1) | BR112019005637A2 (https=) |
| CA (1) | CA3037844A1 (https=) |
| RU (1) | RU2764197C1 (https=) |
| TW (1) | TWI774694B (https=) |
| WO (1) | WO2018056764A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018107117A1 (en) | 2016-12-09 | 2018-06-14 | Akston Biosciences Corporation | Insulin-fc fusions and methods of use |
| KR102629006B1 (ko) * | 2017-03-23 | 2024-01-25 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도 |
| KR20210029210A (ko) | 2018-06-29 | 2021-03-15 | 악스톤 바이오사이언시스 코퍼레이션 | 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| KR20210102347A (ko) | 2018-12-11 | 2021-08-19 | 사노피 | 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체 |
| KR20250142943A (ko) | 2019-12-19 | 2025-09-30 | 악스톤 바이오사이언시스 코퍼레이션 | 초-장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| LT3972987T (lt) | 2020-04-10 | 2023-09-25 | Akston Biosciences Corporation | Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| EP4373861A4 (en) | 2021-07-23 | 2025-08-20 | Akston Biosciences Corp | INSULIN-FC FUSION PROTEINS AND METHODS OF USE FOR TREATING CANCER |
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| KR102629006B1 (ko) | 2017-03-23 | 2024-01-25 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도 |
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2017
- 2017-09-22 JP JP2019515862A patent/JP7158378B2/ja active Active
- 2017-09-22 CA CA3037844A patent/CA3037844A1/en active Pending
- 2017-09-22 TW TW106132612A patent/TWI774694B/zh active
- 2017-09-22 US US16/335,490 patent/US11396534B2/en active Active
- 2017-09-22 CN CN201780071757.1A patent/CN110546161B/zh active Active
- 2017-09-22 KR KR1020170122759A patent/KR102698929B1/ko active Active
- 2017-09-22 AU AU2017332408A patent/AU2017332408B2/en active Active
- 2017-09-22 RU RU2019109608A patent/RU2764197C1/ru active
- 2017-09-22 WO PCT/KR2017/010504 patent/WO2018056764A1/ko not_active Ceased
- 2017-09-22 BR BR112019005637A patent/BR112019005637A2/pt unknown
- 2017-09-22 EP EP17853478.0A patent/EP3517544B1/en active Active
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|---|---|
| AU2017332408B2 (en) | 2022-02-10 |
| TWI774694B (zh) | 2022-08-21 |
| RU2764197C1 (ru) | 2022-01-14 |
| KR102698929B1 (ko) | 2024-08-27 |
| JP7158378B2 (ja) | 2022-10-21 |
| KR20180033105A (ko) | 2018-04-02 |
| TW201813977A (zh) | 2018-04-16 |
| AR109552A1 (es) | 2018-12-19 |
| WO2018056764A1 (ko) | 2018-03-29 |
| CN110546161A (zh) | 2019-12-06 |
| US11396534B2 (en) | 2022-07-26 |
| JP2019531075A (ja) | 2019-10-31 |
| CN110546161B (zh) | 2024-01-26 |
| CA3037844A1 (en) | 2018-03-29 |
| US20190300593A1 (en) | 2019-10-03 |
| EP3517544A1 (en) | 2019-07-31 |
| EP3517544A4 (en) | 2020-06-03 |
| EP3517544C0 (en) | 2025-01-08 |
| AU2017332408A1 (en) | 2019-05-16 |
| EP3517544B1 (en) | 2025-01-08 |
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