TWI772331B - 氧固醇(oxysterol)及其使用方法 - Google Patents

氧固醇(oxysterol)及其使用方法 Download PDF

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TWI772331B
TWI772331B TW106135795A TW106135795A TWI772331B TW I772331 B TWI772331 B TW I772331B TW 106135795 A TW106135795 A TW 106135795A TW 106135795 A TW106135795 A TW 106135795A TW I772331 B TWI772331 B TW I772331B
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substituted
unsubstituted
compound
alkyl
hydrogen
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TW106135795A
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TW201827057A (zh
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法藍西司科 G 薩突羅
艾伯特 J 羅比喬德
柏特拉 加布利爾 馬丁奈茲
柏伊德 L 哈里森
安德魯 葛里芬
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美商賽吉醫療公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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TW106135795A 2016-10-18 2017-10-18 氧固醇(oxysterol)及其使用方法 TWI772331B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662409756P 2016-10-18 2016-10-18
US201662409768P 2016-10-18 2016-10-18
US62/409,756 2016-10-18
US62/409,768 2016-10-18

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TW201827057A TW201827057A (zh) 2018-08-01
TWI772331B true TWI772331B (zh) 2022-08-01

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TW111123637A TWI836485B (zh) 2016-10-18 2017-10-18 氧固醇(oxysterol)及其使用方法
TW106135795A TWI772331B (zh) 2016-10-18 2017-10-18 氧固醇(oxysterol)及其使用方法
TW113106000A TW202446399A (zh) 2016-10-18 2017-10-18 氧固醇(oxysterol)及其使用方法

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US (4) US11111266B2 (enExample)
EP (3) EP4616908A3 (enExample)
JP (4) JP2019532079A (enExample)
KR (3) KR102521573B1 (enExample)
CN (3) CN114891056A (enExample)
AU (3) AU2017345399B2 (enExample)
DK (1) DK4105223T3 (enExample)
ES (2) ES3038660T3 (enExample)
IL (3) IL320521A (enExample)
MA (1) MA46565A (enExample)
MX (2) MX2019004679A (enExample)
RU (1) RU2019115112A (enExample)
TW (3) TWI836485B (enExample)
WO (1) WO2018075698A1 (enExample)

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ES2970222T3 (es) 2014-06-18 2024-05-27 Sage Therapeutics Inc Oxiesteroles y procedimientos de uso de los mismos
SMT202100226T1 (it) 2015-07-06 2021-05-07 Sage Therapeutics Inc Ossisteroli e metodi di uso degli stessi
SG10202002655VA (en) 2015-07-06 2020-05-28 Sage Therapeutics Inc Oxysterols and methods of use thereof
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WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
HUE055263T2 (hu) 2016-07-07 2021-11-29 Sage Therapeutics Inc 11-Szubsztituált 24-hidroxiszterolok NMDA-hoz kapcsolódó állapotok kezelésére
ES2935057T3 (es) 2016-09-30 2023-03-01 Sage Therapeutics Inc C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA
CN119350419A (zh) 2016-10-18 2025-01-24 萨奇治疗股份有限公司 氧甾醇及其使用方法
ES3038660T3 (en) * 2016-10-18 2025-10-14 Sage Therapeutics Inc Oxysterols and methods of use thereof
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CN111560045A (zh) * 2020-06-23 2020-08-21 江苏佳尔科药业集团股份有限公司 一种以ba为原料合成石胆酸的方法
CN112375117A (zh) * 2020-11-14 2021-02-19 湖南科瑞生物制药股份有限公司 石胆酸及其中间体的制备方法
CN113651866B (zh) * 2021-08-02 2023-07-04 王涛 一种以21-羟基-20-甲基孕甾-4-烯-3-酮为原料合成胆固醇的新方法
WO2023083979A1 (en) * 2021-11-10 2023-05-19 Umecrine Ab 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor
WO2023192421A1 (en) 2022-03-30 2023-10-05 Donaldson Company, Inc. System and method for reclaiming solvent
US20250375459A1 (en) * 2022-07-01 2025-12-11 Intercept Pharmaceuticals, Inc. Methods for ameliorating cognitive impairment using bile acid derivatives
WO2024112759A1 (en) * 2022-11-21 2024-05-30 Sage Therapeutics, Inc. Negative nmda-modulating compounds and methods of use thereof
CN115974950A (zh) * 2022-12-23 2023-04-18 上海彩迩文生化科技有限公司 一种3-烷基化的甾体中间体及其制备和应用
WO2025020191A1 (zh) * 2023-07-27 2025-01-30 珂阑(上海)医药科技有限公司 甾类化合物、其制备方法和应用
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