TWI730408B - 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 - Google Patents

過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 Download PDF

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TWI730408B
TWI730408B TW108133069A TW108133069A TWI730408B TW I730408 B TWI730408 B TW I730408B TW 108133069 A TW108133069 A TW 108133069A TW 108133069 A TW108133069 A TW 108133069A TW I730408 B TWI730408 B TW I730408B
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methyl
compound
disease
pharmaceutically acceptable
synthesis
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TW108133069A
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TW201943705A (zh
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麥可 道尼思
羅那德 M 伊凡斯
亞瑟 庫勒吉
巴拉特 拉古
三浦理憲
桑尼爾 庫瑪 潘尼葛西
麥克 帕塔尼
蘇桑塔 薩瑪佳達
拉米許 聖奈爾
高橋泰輔
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美商米突倍基公司
沙克生物研究機構
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    • C07ORGANIC CHEMISTRY
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW108133069A 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法 TWI730408B (zh)

Applications Claiming Priority (6)

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US201562238629P 2015-10-07 2015-10-07
US62/238,629 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US62/243,263 2015-10-19
US201662352348P 2016-06-20 2016-06-20
US62/352,348 2016-06-20

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TW201943705A TW201943705A (zh) 2019-11-16
TWI730408B true TWI730408B (zh) 2021-06-11

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TW108133069A TWI730408B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法
TW105132668A TWI730006B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法
TW108144723A TWI742479B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法

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TW108144723A TWI742479B (zh) 2015-10-07 2016-10-07 過氧化物酶體增生劑活化之受體(ppar)促效劑其化合物其醫藥組合物及其使用方法

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CN109789117B (zh) * 2016-10-05 2022-08-23 米托布里奇公司 治疗急性肾损伤的方法
WO2021046081A1 (en) * 2019-09-05 2021-03-11 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
KR20240037940A (ko) 2021-06-02 2024-03-22 아스테라스 세이야쿠 가부시키가이샤 Ppar 작용제 화합물의 사용 방법 및 이의 약학 조성물
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease
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WO2025207099A1 (en) 2024-03-28 2025-10-02 Astellas Pharma Inc. Ppar-delta inhibitors for preventing post-operative atrial fibrillation

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US20210253549A1 (en) 2021-08-19
KR20180095797A (ko) 2018-08-28
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US10399958B2 (en) 2019-09-03
EP3770146B1 (en) 2024-07-24
MA52648A (fr) 2021-10-13
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MX2020011100A (es) 2022-05-23
JP2018534355A (ja) 2018-11-22
ES2906379T3 (es) 2022-04-18
ZA202003663B (en) 2022-08-31
AU2016333963B2 (en) 2021-01-07
AU2016333963C1 (en) 2021-05-27
CN113004205A (zh) 2021-06-22
JOP20200231A1 (ar) 2022-10-30
PL3359528T3 (pl) 2022-05-30
US20240417383A1 (en) 2024-12-19
MA52098A (fr) 2021-01-27
WO2017062468A1 (en) 2017-04-13
US20190337920A1 (en) 2019-11-07
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
AU2020281069B2 (en) 2022-10-27
CN113024467B (zh) 2024-08-06
US10906885B2 (en) 2021-02-02
EP3795566B1 (en) 2023-04-19
BR112018006866A2 (pt) 2018-10-16
PH12018500762A1 (en) 2018-10-29
TWI742479B (zh) 2021-10-11
TW201722919A (zh) 2017-07-01
TW201943705A (zh) 2019-11-16
CN108349904A (zh) 2018-07-31
EP3770146C0 (en) 2024-07-24
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WO2017062468A8 (en) 2017-05-11
KR102667385B1 (ko) 2024-05-21
EP3795566A1 (en) 2021-03-24
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AU2016333963A1 (en) 2018-04-12
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JP6657413B2 (ja) 2020-03-04
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US11578052B2 (en) 2023-02-14
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IL258225A (en) 2018-05-31
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US20230373948A1 (en) 2023-11-23
AU2019283837A1 (en) 2020-01-16
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SG10201906400SA (en) 2019-08-27
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UA122237C2 (uk) 2020-10-12
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EA201890776A1 (ru) 2018-09-28
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US20200157074A1 (en) 2020-05-21
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US10479775B1 (en) 2019-11-19
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ZA202003662B (en) 2022-08-31
ZA201802029B (en) 2022-01-26
JOP20200230A1 (ar) 2022-10-30
ZA202003664B (en) 2022-08-31
US20190084958A1 (en) 2019-03-21
IL275387A (en) 2020-07-30
TWI730006B (zh) 2021-06-11
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