TWI701250B - 雜芳基吡啶酮及氮雜吡啶酮化合物 - Google Patents

雜芳基吡啶酮及氮雜吡啶酮化合物 Download PDF

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TWI701250B
TWI701250B TW107141781A TW107141781A TWI701250B TW I701250 B TWI701250 B TW I701250B TW 107141781 A TW107141781 A TW 107141781A TW 107141781 A TW107141781 A TW 107141781A TW I701250 B TWI701250 B TW I701250B
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methyl
mmol
dimethyl
ylamino
tetrahydro
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TW107141781A
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TW201906845A (zh
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約翰 奎福特詹姆士
佛瑞德 歐特懷恩丹尼爾
魏斌清
B 楊溫蒂
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美商建南德克公司
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW107141781A 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物 TWI701250B (zh)

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US201161555393P 2011-11-03 2011-11-03
US61/555,393 2011-11-03

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TW109129648A TW202124384A (zh) 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物
TW106130019A TWI652270B (zh) 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物
TW101140919A TWI609868B (zh) 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物
TW107141781A TWI701250B (zh) 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物

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TW109129648A TW202124384A (zh) 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物
TW106130019A TWI652270B (zh) 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物
TW101140919A TWI609868B (zh) 2011-11-03 2012-11-02 雜芳基吡啶酮及氮雜吡啶酮化合物

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MX2014005289A (es) * 2011-11-03 2014-05-30 Hoffmann La Roche Compuestos de piperazina alquilados.
RU2016101548A (ru) 2013-07-03 2017-08-08 Ф. Хоффманн-Ля Рош Аг Соединения амидов гетероарилпиридона и азапиридона
JP2016535764A (ja) * 2013-10-04 2016-11-17 ビヨンド オンコロジー ファーマシューティカル エルエルシー ブルトンのチロシンキナーゼの阻害剤
CN105793251B (zh) * 2013-12-05 2018-10-12 豪夫迈·罗氏有限公司 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物
WO2016050921A1 (en) 2014-10-02 2016-04-07 F. Hoffmann-La Roche Ag Pyrazole carboxamide compounds for use in the treament of disorders mediated by bruton's tyrosine kinase (btk)
EP3212645B1 (en) 2014-10-27 2018-11-28 F.Hoffmann-La Roche Ag Process for making tricyclic lactam compounds
CN106188063A (zh) * 2015-05-08 2016-12-07 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途
AR105875A1 (es) 2015-09-02 2017-11-15 GLAXOSMITHKLINE INTELLECTUAL PROPERTY (Nº 2) LTD Derivados de 2-oxo-1,2-dihidropiridina como inhibidores de bromodominio
WO2017070708A1 (en) 2015-10-23 2017-04-27 Array Biopharma, Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases
WO2017140821A1 (en) * 2016-02-19 2017-08-24 Novartis Ag Tetracyclic pyridone compounds as antivirals
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