PT3002284T - Compostos heteroarílicos de piridona e azapiridona enquanto inibidores da atividade de btk - Google Patents
Compostos heteroarílicos de piridona e azapiridona enquanto inibidores da atividade de btkInfo
- Publication number
- PT3002284T PT3002284T PT15188086T PT15188086T PT3002284T PT 3002284 T PT3002284 T PT 3002284T PT 15188086 T PT15188086 T PT 15188086T PT 15188086 T PT15188086 T PT 15188086T PT 3002284 T PT3002284 T PT 3002284T
- Authority
- PT
- Portugal
- Prior art keywords
- pyridone
- aza
- inhibitors
- heteroaryl
- btk activity
- Prior art date
Links
- -1 Heteroaryl pyridone Chemical compound 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161555393P | 2011-11-03 | 2011-11-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3002284T true PT3002284T (pt) | 2019-07-17 |
Family
ID=47146779
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT15188086T PT3002284T (pt) | 2011-11-03 | 2012-11-02 | Compostos heteroarílicos de piridona e azapiridona enquanto inibidores da atividade de btk |
PT127838373T PT2773638E (pt) | 2011-11-03 | 2012-11-02 | Compostos de heteroaril-piridona e aza-piridona como inibidores da atividade de btk |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT127838373T PT2773638E (pt) | 2011-11-03 | 2012-11-02 | Compostos de heteroaril-piridona e aza-piridona como inibidores da atividade de btk |
Country Status (34)
Country | Link |
---|---|
US (10) | US8716274B2 (pt) |
EP (5) | EP3002284B1 (pt) |
JP (5) | JP5976827B2 (pt) |
KR (2) | KR20160003328A (pt) |
CN (2) | CN107011348B (pt) |
AR (2) | AR088641A1 (pt) |
AU (5) | AU2012332365B2 (pt) |
CA (1) | CA2853975C (pt) |
CL (1) | CL2014001103A1 (pt) |
CO (1) | CO6950472A2 (pt) |
CR (1) | CR20140194A (pt) |
CY (1) | CY1117097T1 (pt) |
DK (2) | DK3002284T3 (pt) |
EA (1) | EA023263B1 (pt) |
ES (3) | ES2898938T3 (pt) |
HK (1) | HK1201265A1 (pt) |
HR (2) | HRP20151442T1 (pt) |
HU (2) | HUE044959T2 (pt) |
IL (1) | IL232060A (pt) |
IN (1) | IN2014CN03250A (pt) |
LT (1) | LT3002284T (pt) |
MA (1) | MA35819B1 (pt) |
MX (2) | MX2014005331A (pt) |
PE (1) | PE20141586A1 (pt) |
PL (3) | PL2773638T3 (pt) |
PT (2) | PT3002284T (pt) |
RS (2) | RS59016B1 (pt) |
SG (1) | SG11201401992YA (pt) |
SI (2) | SI2773638T1 (pt) |
TR (1) | TR201909849T4 (pt) |
TW (4) | TW202124384A (pt) |
UA (1) | UA111756C2 (pt) |
WO (1) | WO2013067274A1 (pt) |
ZA (1) | ZA201804727B (pt) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
AR088642A1 (es) * | 2011-11-03 | 2014-06-25 | Genentech Inc | Compuestos de piperazina alquilados |
US9326985B2 (en) | 2013-07-03 | 2016-05-03 | Genentech, Inc. | Heteroaryl pyridone and aza-pyridone amide compounds |
WO2015050703A1 (en) * | 2013-10-04 | 2015-04-09 | Yi Chen | Inhibitors of bruton's tyrosine kinase |
JP6275846B2 (ja) * | 2013-12-05 | 2018-02-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物 |
CN111303159A (zh) * | 2014-10-02 | 2020-06-19 | 豪夫迈·罗氏有限公司 | 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物 |
EP3212645B1 (en) | 2014-10-27 | 2018-11-28 | F.Hoffmann-La Roche Ag | Process for making tricyclic lactam compounds |
CN106188063A (zh) * | 2015-05-08 | 2016-12-07 | 中国科学院上海药物研究所 | 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途 |
UY36875A (es) | 2015-09-02 | 2017-03-31 | Glaxosmithkline Intellectual Property (No 2) Ltd | Composiciones inhibidoras de bromodominios para el tratamiento de diversas enfermedades |
US10208024B2 (en) | 2015-10-23 | 2019-02-19 | Array Biopharma Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases |
MX2018010010A (es) * | 2016-02-19 | 2018-11-09 | Novartis Ag | Compuestos tetraciclicos de piridona como antivirales. |
JP6577143B2 (ja) * | 2016-02-29 | 2019-09-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトンチロシンキナーゼの阻害剤を含む剤形組成物 |
CN108473510B (zh) * | 2016-04-28 | 2021-10-29 | 豪夫迈·罗氏有限公司 | 制备2-吡唑并[1,5-a]吡嗪-2-基吡啶并[1,2-a]嘧啶-4-酮的方法 |
CN108101905A (zh) * | 2016-11-24 | 2018-06-01 | 中国科学院上海药物研究所 | 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途 |
WO2018102785A2 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
EP3551226A1 (en) | 2016-12-12 | 2019-10-16 | MultiVir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
WO2018109050A1 (en) * | 2016-12-15 | 2018-06-21 | F. Hoffmann-La Roche Ag | Process for preparing btk inhibitors |
ES2917377T3 (es) | 2016-12-22 | 2022-07-08 | Betta Pharmaceuticals Co Ltd | Derivados de benzimidazol, procedimientos de preparación y utilizaciones de los mismos |
TW201836642A (zh) | 2017-03-24 | 2018-10-16 | 美商建南德克公司 | 治療自體免疫及發炎疾病的方法 |
CN107445981B (zh) * | 2017-08-25 | 2018-06-22 | 牡丹江医学院 | 一种用于防治宫颈炎的活性化合物 |
KR102613433B1 (ko) * | 2017-10-11 | 2023-12-13 | 주식회사 대웅제약 | 신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물 |
JP7100125B2 (ja) | 2017-10-27 | 2022-07-12 | フレゼニウス・カビ・オンコロジー・リミテッド | リボシクリブおよびその塩の改善された調製のためのプロセス |
US11100492B2 (en) * | 2018-02-19 | 2021-08-24 | Peter Garrett | General purpose re-loadable card aggregation implementation |
TWI801517B (zh) | 2018-03-12 | 2023-05-11 | 加拿大商愛彼特生物製藥公司 | 經取代的2-吡啶酮三環化合物、其類似物及其使用方法 |
JP7331843B2 (ja) | 2018-04-27 | 2023-08-23 | 小野薬品工業株式会社 | Btk阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および/または治療剤 |
MA53388A (fr) | 2018-07-25 | 2021-06-02 | Novartis Ag | Inhibiteurs d'inflammasome nlrp3 |
KR102328682B1 (ko) * | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
WO2020043321A1 (en) | 2018-08-31 | 2020-03-05 | Stichting Katholieke Universiteit | Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof |
WO2020081450A1 (en) | 2018-10-15 | 2020-04-23 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
TW202033523A (zh) * | 2019-01-17 | 2020-09-16 | 美商愛彼特生物製藥股份有限公司 | 經取代的多環羧酸、其類似物及使用其之方法 |
MX2021008696A (es) | 2019-01-22 | 2021-08-19 | Hoffmann La Roche | Metodos para tratar artritis reumatoide, urticaria espontanea cronica y lupus eritematoso diseminado mediante el uso de un inhibidor de tirosina quinasa de bruton. |
EP3930717A1 (en) | 2019-02-25 | 2022-01-05 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Inhibitor of btk and mutants thereof |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2020210508A1 (en) | 2019-04-09 | 2020-10-15 | Nurix Therapeutics, Inc. | 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus |
AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
MX2021013751A (es) | 2019-05-17 | 2022-01-26 | Nurix Therapeutics Inc | Compuestos de ciano ciclobutilo para la inhibicion del protooncogen b de linfoma de linaje b de casitas (cbl-b) y usos de los mismos. |
US20220363689A1 (en) | 2019-10-05 | 2022-11-17 | Newave Pharmaceutical Inc. | Inhibitor of btk and mutants thereof |
EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021091575A1 (en) * | 2019-11-08 | 2021-05-14 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
EP4069237A1 (en) | 2019-12-04 | 2022-10-12 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
WO2021164735A1 (en) * | 2020-02-20 | 2021-08-26 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
CN115175682A (zh) | 2020-02-28 | 2022-10-11 | 基因泰克公司 | 使用布鲁顿氏酪氨酸激酶的抑制剂治疗原发进展型多发性硬化症的方法 |
EP4125906A1 (en) | 2020-04-03 | 2023-02-08 | Genentech, Inc. | Methods of treating relapsing multiple sclerosis using an inhibitor of bruton's tyrosine kinase |
CN115715291A (zh) * | 2020-06-18 | 2023-02-24 | 上海华汇拓医药科技有限公司 | 布鲁顿酪氨酸激酶抑制剂及其制备方法 |
EP4192822A1 (en) * | 2020-08-04 | 2023-06-14 | F. Hoffmann-La Roche AG | Pyridinone compounds for the treatment of autoimmune disease |
MX2023001865A (es) * | 2020-08-14 | 2023-05-09 | Guangzhou Lupeng Pharmaceutical Company Ltd | Composiciones de forma de dosificación que comprenden un inhibidor de btk y mutantes de este. |
US11708366B2 (en) | 2020-08-14 | 2023-07-25 | Novartis Ag | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof |
TW202220998A (zh) | 2020-09-21 | 2022-06-01 | 大陸商和記黃埔醫藥(上海)有限公司 | 雜芳基雜環化合物及其用途 |
US20230382900A1 (en) | 2020-10-30 | 2023-11-30 | Newave Pharmaceutical Inc. | Inhibitors of btk |
CA3202745A1 (en) | 2020-12-20 | 2022-06-23 | Yi Chen | Btk degrader |
WO2022212893A1 (en) | 2021-04-02 | 2022-10-06 | Biogen Ma Inc. | Combination treatment methods of multiple sclerosis |
JP2024517004A (ja) | 2021-05-05 | 2024-04-18 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Btk阻害剤を調製するための方法 |
CN113603685A (zh) * | 2021-07-23 | 2021-11-05 | 都创(上海)医药开发有限公司 | Fenebrutinib化合物的晶型及其制备方法和用途 |
WO2023110970A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Macrocyclic btk inhibitors |
WO2023137225A1 (en) * | 2022-01-17 | 2023-07-20 | Newave Pharmaceutical Inc. | Btk degrader |
WO2023143491A1 (zh) * | 2022-01-28 | 2023-08-03 | 和记黄埔医药(上海)有限公司 | 7,8-二氢-2h-环戊二烯并吡咯并吡嗪酮化合物的合成方法 |
US20240067627A1 (en) | 2022-08-03 | 2024-02-29 | Novartis Ag | Nlrp3 inflammasome inhibitors |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
BR0211073A (pt) | 2001-07-12 | 2004-12-14 | Avecia Ltd | Sistema de catalisador, e, processos para a preparação de um catalisador microencapsulado, de bifenilas opcionalmente substituìdas, de alcenos opcionalmente substituìdos, de um produto hidrogenado e de dióis |
WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
WO2005005429A1 (en) | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
WO2006017295A2 (en) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
WO2006053121A2 (en) | 2004-11-10 | 2006-05-18 | Cgi Pharmaceuticals, Inc. | Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity |
ES2543607T3 (es) | 2005-03-10 | 2015-08-20 | Gilead Connecticut, Inc. | Ciertas amidas sustituidas, método de obtención, y método de su uso |
ATE504565T1 (de) | 2005-10-07 | 2011-04-15 | Exelixis Inc | Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen |
AR063946A1 (es) | 2006-09-11 | 2009-03-04 | Cgi Pharmaceuticals Inc | Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. |
AR063706A1 (es) | 2006-09-11 | 2009-02-11 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. |
US7838523B2 (en) | 2006-09-11 | 2010-11-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
DK2081435T3 (en) * | 2006-09-22 | 2016-08-15 | Pharmacyclics Llc | INHIBITORS OF BRUTON'S TYROSINKINASE |
CL2008002793A1 (es) | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
JP5587193B2 (ja) * | 2007-10-23 | 2014-09-10 | エフ.ホフマン−ラ ロシュ アーゲー | 新規なキナーゼ阻害剤 |
US8426441B2 (en) | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
US7683064B2 (en) | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
ES2420846T3 (es) * | 2008-02-05 | 2013-08-27 | F. Hoffmann-La Roche Ag | Nuevas piridinonas y piridazinonas |
EP2297105B1 (en) | 2008-05-06 | 2015-09-02 | Gilead Connecticut, Inc. | Substituted amides, method of making, and use as btk inhibitors |
PE20100851A1 (es) | 2008-06-24 | 2011-01-31 | Hoffmann La Roche | PIRIDIN-2-ONAS Y PIRIDAZIN-3-ONAS SUSTITUIDAS COMO INHIBIDORES DE Btk |
EP2300459B1 (en) | 2008-07-02 | 2013-05-29 | F. Hoffmann-La Roche AG | Novel phenylpyrazinones as kinase inhibitors |
CA2636807A1 (en) | 2008-07-04 | 2010-01-04 | Steven Splinter | Methods for obtaining cyclopamine |
WO2010006947A1 (en) | 2008-07-15 | 2010-01-21 | F. Hoffmann-La Roche Ag | Novel phenyl-imidazopyridines and pyridazines |
EP2365970B1 (en) | 2008-11-12 | 2018-03-21 | Gilead Connecticut, Inc. | Pyridazinones and their use as btk inhibitors |
US8299077B2 (en) | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
CN102292329B (zh) * | 2009-04-24 | 2014-09-03 | 霍夫曼-拉罗奇有限公司 | 布鲁顿酪氨酸激酶的抑制剂 |
WO2010126960A1 (en) * | 2009-04-29 | 2010-11-04 | Locus Pharmaceuticals, Inc. | Pyrrolotriazine compounds |
WO2011029046A1 (en) * | 2009-09-04 | 2011-03-10 | Biogen Idec Ma Inc. | Bruton's tyrosine kinase inhibitors |
AU2011249912A1 (en) * | 2010-05-07 | 2012-11-29 | Genentech, Inc. | Pyridone and aza-pyridone compounds and methods of use |
AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
US9249123B2 (en) | 2010-09-01 | 2016-02-02 | Genentech, Inc. | Pyridinones/pyrazinones, method of making, and method of use thereof |
CN103201277B (zh) | 2010-09-01 | 2015-11-25 | 吉利德康涅狄格有限公司 | 哒嗪酮、其制备方法及使用方法 |
EP2709997B1 (en) | 2011-05-17 | 2016-06-29 | F.Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
EP2744804B1 (en) | 2011-08-17 | 2017-05-17 | F. Hoffmann-La Roche AG | Inhibitors of bruton's tyrosine kinase |
UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
WO2013067264A1 (en) * | 2011-11-03 | 2013-05-10 | Genentech, Inc. | 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity |
AR088642A1 (es) | 2011-11-03 | 2014-06-25 | Genentech Inc | Compuestos de piperazina alquilados |
US9326985B2 (en) * | 2013-07-03 | 2016-05-03 | Genentech, Inc. | Heteroaryl pyridone and aza-pyridone amide compounds |
JP6275846B2 (ja) * | 2013-12-05 | 2018-02-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物 |
JP6577143B2 (ja) * | 2016-02-29 | 2019-09-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトンチロシンキナーゼの阻害剤を含む剤形組成物 |
-
2012
- 2012-02-11 UA UAA201405799A patent/UA111756C2/uk unknown
- 2012-11-02 SI SI201230367T patent/SI2773638T1/sl unknown
- 2012-11-02 PT PT15188086T patent/PT3002284T/pt unknown
- 2012-11-02 TW TW109129648A patent/TW202124384A/zh unknown
- 2012-11-02 HU HUE15188086A patent/HUE044959T2/hu unknown
- 2012-11-02 EP EP15188086.1A patent/EP3002284B1/en active Active
- 2012-11-02 EP EP12783837.3A patent/EP2773638B1/en active Active
- 2012-11-02 RS RS20190888A patent/RS59016B1/sr unknown
- 2012-11-02 MX MX2014005331A patent/MX2014005331A/es active IP Right Grant
- 2012-11-02 RS RS20160001A patent/RS54505B1/en unknown
- 2012-11-02 MX MX2015003514A patent/MX361807B/es unknown
- 2012-11-02 ES ES19152979T patent/ES2898938T3/es active Active
- 2012-11-02 PL PL12783837T patent/PL2773638T3/pl unknown
- 2012-11-02 HU HUE12783837A patent/HUE028019T2/en unknown
- 2012-11-02 CN CN201710227680.4A patent/CN107011348B/zh active Active
- 2012-11-02 AR ARP120104128A patent/AR088641A1/es active IP Right Grant
- 2012-11-02 TW TW106130019A patent/TWI652270B/zh active
- 2012-11-02 KR KR1020157036122A patent/KR20160003328A/ko not_active Application Discontinuation
- 2012-11-02 CN CN201280065965.8A patent/CN104125959B/zh active Active
- 2012-11-02 EP EP19152979.1A patent/EP3521288B1/en active Active
- 2012-11-02 US US13/667,133 patent/US8716274B2/en not_active Ceased
- 2012-11-02 KR KR1020147014661A patent/KR101659193B1/ko active IP Right Grant
- 2012-11-02 DK DK15188086.1T patent/DK3002284T3/da active
- 2012-11-02 LT LTEP15188086.1T patent/LT3002284T/lt unknown
- 2012-11-02 PE PE2014000638A patent/PE20141586A1/es active IP Right Grant
- 2012-11-02 EA EA201490858A patent/EA023263B1/ru unknown
- 2012-11-02 TR TR2019/09849T patent/TR201909849T4/tr unknown
- 2012-11-02 DK DK12783837.3T patent/DK2773638T3/en active
- 2012-11-02 IN IN3250CHN2014 patent/IN2014CN03250A/en unknown
- 2012-11-02 AU AU2012332365A patent/AU2012332365B2/en active Active
- 2012-11-02 EP EP22157147.4A patent/EP4050012A1/en active Pending
- 2012-11-02 EP EP21171114.8A patent/EP4019508A1/en active Pending
- 2012-11-02 WO PCT/US2012/063194 patent/WO2013067274A1/en active Application Filing
- 2012-11-02 TW TW101140919A patent/TWI609868B/zh active
- 2012-11-02 PT PT127838373T patent/PT2773638E/pt unknown
- 2012-11-02 JP JP2014541114A patent/JP5976827B2/ja active Active
- 2012-11-02 TW TW107141781A patent/TWI701250B/zh active
- 2012-11-02 CA CA2853975A patent/CA2853975C/en active Active
- 2012-11-02 SG SG11201401992YA patent/SG11201401992YA/en unknown
- 2012-11-02 ES ES15188086T patent/ES2738329T3/es active Active
- 2012-11-02 PL PL19152979T patent/PL3521288T3/pl unknown
- 2012-11-02 ES ES12783837.3T patent/ES2555168T3/es active Active
- 2012-11-02 PL PL15188086T patent/PL3002284T3/pl unknown
- 2012-11-02 SI SI201231643T patent/SI3002284T1/sl unknown
-
2014
- 2014-03-13 US US14/207,966 patent/US8921353B2/en active Active
- 2014-04-10 IL IL232060A patent/IL232060A/en active IP Right Grant
- 2014-04-28 CR CR20140194A patent/CR20140194A/es unknown
- 2014-04-28 CO CO14090476A patent/CO6950472A2/es active IP Right Grant
- 2014-04-29 CL CL2014001103A patent/CL2014001103A1/es unknown
- 2014-05-27 MA MA37075A patent/MA35819B1/fr unknown
- 2014-09-08 US US14/479,529 patent/US9238655B2/en active Active
-
2015
- 2015-02-18 HK HK15101799.4A patent/HK1201265A1/xx unknown
- 2015-08-24 JP JP2015165300A patent/JP2016028046A/ja not_active Withdrawn
- 2015-11-17 US US14/943,552 patent/US9782405B2/en active Active
- 2015-12-31 HR HRP20151442TT patent/HRP20151442T1/hr unknown
-
2016
- 2016-01-04 CY CY20161100003T patent/CY1117097T1/el unknown
- 2016-12-15 AU AU2016273930A patent/AU2016273930B2/en active Active
-
2017
- 2017-08-31 US US15/693,022 patent/US10045983B2/en active Active
-
2018
- 2018-01-04 JP JP2018000309A patent/JP6571215B2/ja active Active
- 2018-03-05 AU AU2018201557A patent/AU2018201557B2/en active Active
- 2018-06-27 US US16/020,270 patent/US20190194203A1/en not_active Abandoned
- 2018-07-16 ZA ZA2018/04727A patent/ZA201804727B/en unknown
- 2018-10-30 US US16/175,278 patent/USRE48239E1/en active Active
-
2019
- 2019-02-14 JP JP2019024668A patent/JP2019108342A/ja not_active Withdrawn
- 2019-07-18 HR HRP20191307TT patent/HRP20191307T1/hr unknown
- 2019-08-16 AU AU2019216728A patent/AU2019216728B2/en active Active
- 2019-10-31 US US16/670,898 patent/US20200062769A1/en not_active Abandoned
- 2019-12-23 AR ARP190103844A patent/AR117501A2/es unknown
-
2020
- 2020-04-22 AU AU2020202707A patent/AU2020202707B2/en active Active
- 2020-07-02 JP JP2020114594A patent/JP2020183397A/ja not_active Withdrawn
- 2020-08-24 US US17/001,205 patent/US20210079002A1/en not_active Abandoned
-
2022
- 2022-12-20 US US18/069,099 patent/US20230279012A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201804727B (en) | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of btk activity | |
HK1243417A1 (zh) | 吡啶酮和氮雜吡啶酮化合物及使用方法 | |
EP2903613A4 (en) | INHIBITORS OF IRAQ4 ACTIVITY | |
HK1205111A1 (en) | 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity btk 8--1(2h)- | |
EP2663565A4 (en) | HEZEROARYL COMPOUNDS AND METHOD FOR USE THEREOF | |
HK1208026A1 (en) | Heteroaryl inhibitors of pde4 pde4 | |
EP2903617A4 (en) | INHIBITORS OF IRAQ4 ACTIVITY | |
HK1197234A1 (en) | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity btk | |
HK1203954A1 (en) | Heteroaryl compounds and methods of use thereof | |
HK1203494A1 (en) | Heteroaryl compounds and methods of use thereof | |
EP2847193A4 (en) | HEZEROARYL COMPOUNDS AND METHOD FOR USE THEREOF | |
TH1401002406B (th) | สารประกอบเฮทเทอโรเอริล ไพริโดน และ อะซา-ไพริโดนในรูปสารยับยั้งของ btk แอคตีวิตี้ |