TWI699367B - 用於製備丁基原啡因之方法 - Google Patents

用於製備丁基原啡因之方法 Download PDF

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Publication number
TWI699367B
TWI699367B TW105107434A TW105107434A TWI699367B TW I699367 B TWI699367 B TW I699367B TW 105107434 A TW105107434 A TW 105107434A TW 105107434 A TW105107434 A TW 105107434A TW I699367 B TWI699367 B TW I699367B
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TW
Taiwan
Prior art keywords
less
acetate
butylprophine
free base
butyl
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TW105107434A
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English (en)
Chinese (zh)
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TW201639856A (zh
Inventor
希 杭特利
艾瑞克 卡泰斯托
賀吉 瑞斯克
亞奇安納 夏瑪
加克 史迪密斯特
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美商羅德科技公司
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Publication of TW201639856A publication Critical patent/TW201639856A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
TW105107434A 2015-03-10 2016-03-10 用於製備丁基原啡因之方法 TWI699367B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131114P 2015-03-10 2015-03-10
US62/131,114 2015-03-10

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Publication Number Publication Date
TW201639856A TW201639856A (zh) 2016-11-16
TWI699367B true TWI699367B (zh) 2020-07-21

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TW109106564A TW202037597A (zh) 2015-03-10 2016-03-10 用於製備丁基原啡因之方法

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US (6) US10406152B2 (enExample)
EP (1) EP3283490A1 (enExample)
JP (2) JP6660399B2 (enExample)
KR (2) KR20200045010A (enExample)
CN (1) CN107660207B (enExample)
AR (1) AR103902A1 (enExample)
AU (2) AU2016230750B2 (enExample)
BR (1) BR112017019357A2 (enExample)
CA (2) CA3104099A1 (enExample)
CO (1) CO2017009130A2 (enExample)
EA (1) EA201792014A1 (enExample)
IL (1) IL254384A0 (enExample)
MA (1) MA45902A (enExample)
MX (1) MX2017011606A (enExample)
NZ (1) NZ735736A (enExample)
PH (1) PH12017501641A1 (enExample)
SG (1) SG11201707350TA (enExample)
TW (2) TWI699367B (enExample)
WO (1) WO2016142877A1 (enExample)

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CN105247038B (zh) 2013-03-15 2021-08-27 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)的微生物及其制备和使用方法
CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
CA3104099A1 (en) 2015-03-10 2016-09-15 Rhodes Technologies Acetate salt of buprenorphine and methods for preparing buprenorphine
CN107614688B (zh) 2015-05-04 2023-02-28 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物及其制备和使用方法
JP7266966B2 (ja) 2015-05-08 2023-05-01 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法
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CN120399912A (zh) 2019-03-08 2025-08-01 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
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Also Published As

Publication number Publication date
TW202037597A (zh) 2020-10-16
MX2017011606A (es) 2017-10-26
US20190314364A1 (en) 2019-10-17
US20210046066A1 (en) 2021-02-18
US10874662B2 (en) 2020-12-29
CN107660207B (zh) 2020-09-29
MA45902A (fr) 2019-06-19
JP6660399B2 (ja) 2020-03-11
JP2020033359A (ja) 2020-03-05
WO2016142877A1 (en) 2016-09-15
EP3283490A1 (en) 2018-02-21
AU2016230750B2 (en) 2019-05-30
IL254384A0 (en) 2017-11-30
SG11201707350TA (en) 2017-10-30
US10835528B2 (en) 2020-11-17
CO2017009130A2 (es) 2017-11-21
CA2977732A1 (en) 2016-09-15
NZ735736A (en) 2019-02-22
US9926329B2 (en) 2018-03-27
KR20200045010A (ko) 2020-04-29
CN107660207A (zh) 2018-02-02
PH12017501641A1 (en) 2018-02-12
US10406152B2 (en) 2019-09-10
AU2019203308A1 (en) 2019-05-30
US20180162866A1 (en) 2018-06-14
JP2018507882A (ja) 2018-03-22
AR103902A1 (es) 2017-06-14
US10278967B2 (en) 2019-05-07
EA201792014A1 (ru) 2018-01-31
CA3104099A1 (en) 2016-09-15
KR20170137738A (ko) 2017-12-13
BR112017019357A2 (pt) 2018-06-05
TW201639856A (zh) 2016-11-16
US20190298713A1 (en) 2019-10-03
US20170197975A1 (en) 2017-07-13
CA2977732C (en) 2021-02-23
AU2016230750A1 (en) 2017-10-12
US20180235955A1 (en) 2018-08-23

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