BR112017019357A2 - sal acetato de buprenorfina e métodos para preparar buprenorfina - Google Patents

sal acetato de buprenorfina e métodos para preparar buprenorfina

Info

Publication number
BR112017019357A2
BR112017019357A2 BR112017019357A BR112017019357A BR112017019357A2 BR 112017019357 A2 BR112017019357 A2 BR 112017019357A2 BR 112017019357 A BR112017019357 A BR 112017019357A BR 112017019357 A BR112017019357 A BR 112017019357A BR 112017019357 A2 BR112017019357 A2 BR 112017019357A2
Authority
BR
Brazil
Prior art keywords
buprenorphine
preparing
methods
acetate salt
acetate salts
Prior art date
Application number
BR112017019357A
Other languages
English (en)
Portuguese (pt)
Inventor
Sharma Archana
Wayne Kataisto Erik
Huntley Frederick
Alfred REISCH Helge
Larry STYMIEST Jake
Original Assignee
Rhodes Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Tech filed Critical Rhodes Tech
Publication of BR112017019357A2 publication Critical patent/BR112017019357A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
BR112017019357A 2015-03-10 2016-03-09 sal acetato de buprenorfina e métodos para preparar buprenorfina BR112017019357A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131114P 2015-03-10 2015-03-10
PCT/IB2016/051332 WO2016142877A1 (en) 2015-03-10 2016-03-09 Acetate salt of buprenorphine and methods for preparing buprenorphine

Publications (1)

Publication Number Publication Date
BR112017019357A2 true BR112017019357A2 (pt) 2018-06-05

Family

ID=55524412

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017019357A BR112017019357A2 (pt) 2015-03-10 2016-03-09 sal acetato de buprenorfina e métodos para preparar buprenorfina

Country Status (19)

Country Link
US (6) US10406152B2 (enExample)
EP (1) EP3283490A1 (enExample)
JP (2) JP6660399B2 (enExample)
KR (2) KR20170137738A (enExample)
CN (1) CN107660207B (enExample)
AR (1) AR103902A1 (enExample)
AU (2) AU2016230750B2 (enExample)
BR (1) BR112017019357A2 (enExample)
CA (2) CA3104099A1 (enExample)
CO (1) CO2017009130A2 (enExample)
EA (1) EA201792014A1 (enExample)
IL (1) IL254384A0 (enExample)
MA (1) MA45902A (enExample)
MX (1) MX2017011606A (enExample)
NZ (1) NZ735736A (enExample)
PH (1) PH12017501641A1 (enExample)
SG (1) SG11201707350TA (enExample)
TW (2) TW202037597A (enExample)
WO (1) WO2016142877A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ711538A (en) 2013-03-15 2017-03-31 Univ Leland Stanford Junior Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same
US11124814B2 (en) 2013-11-04 2021-09-21 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same
CA3104099A1 (en) 2015-03-10 2016-09-15 Rhodes Technologies Acetate salt of buprenorphine and methods for preparing buprenorphine
WO2016179296A1 (en) 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
CA2983445A1 (en) 2015-05-08 2016-11-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
AU2017345328C1 (en) 2016-10-18 2023-03-02 Antheia, Inc. Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids
WO2019028390A1 (en) 2017-08-03 2019-02-07 Antheia, Inc. ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
NZ766474A (en) * 2018-05-11 2023-03-31 Alar Pharmaceuticals Inc Long-acting injectable formulations and crystalline forms of buprenorphine derivatives
EP3934765A4 (en) 2019-03-08 2022-11-30 The Board Of Trustees Of The Leland Stanford Junior University TROPANE ALKALOID (TA) PRODUCING NON-PLANT HOST CELLS AND METHODS FOR THEIR MANUFACTURE AND USE
IL317873A (en) * 2022-06-24 2025-02-01 Alar Pharmaceuticals Inc Stable pharmaceutical composition of buprenorphine and method of preparation and use thereof

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275638A (en) * 1966-09-27 Chjcoo-
US2191786A (en) 1938-03-18 1940-02-27 C A Miketta Continuous process for making adipic acid
BE466549A (enExample) 1945-07-17
US3355486A (en) 1965-01-08 1967-11-28 Fmc Corp Continuous process of synthesizing amino-iminomethane-sulfinic acid
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
GB1312447A (en) 1969-05-14 1973-04-04 Nat Res Dev Method of continuous addition of a component to a chemical or biological system and apparatus therefor
US4217287A (en) 1971-10-06 1980-08-12 Gulf Research & Development Company Epoxidation of alpha-olefins
US3936462A (en) * 1972-05-26 1976-02-03 Sterling Drug Inc. 1,2,3,4,5,6-Hexahydro-1-oxo or hydroxy-3-acyl-2,6-methano-3-benzazocines and corresponding 1-esters thereof
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
GB1520139A (en) 1976-06-08 1978-08-02 Ferranti Ltd Gyroscopic apparatus
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4830028A (en) 1987-02-10 1989-05-16 R. J. Reynolds Tobacco Company Salts provided from nicotine and organic acid as cigarette additives
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
CA2002299A1 (en) 1988-11-10 1990-05-10 Eugene G. Drust Compositions for the transdermal delivery of buprenorphine salts
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6344211B1 (en) 1994-12-24 2002-02-05 Lts Lohmann Therapie-Systeme Gmbh Transdermal absorption of active substances from subcooled melts
DE4446600A1 (de) 1994-12-24 1996-06-27 Lohmann Therapie Syst Lts Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
TW452907B (en) 1999-11-22 2001-09-01 Winbond Electronics Corp Testing device and method of positive mobile ion contamination
US6994827B2 (en) 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US7842307B2 (en) 2001-08-06 2010-11-30 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US7560445B2 (en) 2005-07-06 2009-07-14 Taro Pharmaceuticals North America, Inc. Process for preparing malathion for pharmaceutical use
DE102006054731B4 (de) 2006-11-21 2013-02-28 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie
CA2671518C (en) 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
EP2114953B1 (en) 2006-12-11 2012-06-06 Alcon Research, Ltd. Process for preparing substantially pure fluorescein
WO2010016219A1 (ja) * 2008-08-05 2010-02-11 株式会社メドレックス 塩基性薬効成分の脂肪酸塩、安息香酸塩を含有する外用剤とその製造方法
WO2011005452A1 (en) * 2009-07-09 2011-01-13 Mallinckrodt Inc. Method for the enrichment of buprenorphine using chromatographic techniques
PL2621496T5 (pl) * 2010-09-30 2019-05-31 Astrazeneca Ab Krystaliczny koniugat naloksol-peg
TW201338813A (zh) 2011-12-12 2013-10-01 Lohmann Therapie Syst Lts 經皮遞送系統
HK1206978A1 (en) 2012-04-17 2016-01-22 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
AU2013205080B2 (en) 2012-12-12 2016-07-07 Lts Lohmann Therapie-Systeme Ag Transdermal Delivery System
EP2941433B1 (en) * 2012-12-31 2019-08-07 Rhodes Technologies Process for preparing 7 -substituted 6 ,14 -ethenomorphinans and 7 -substituted 6 ,14 -ethanomorphinans
AU2014276910B2 (en) 2013-06-04 2017-03-09 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system
CN103408553B (zh) * 2013-08-20 2016-02-03 宜昌人福药业有限责任公司 一种氢吗啡酮酸式盐的精制工艺
US8846923B1 (en) * 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
CA3104099A1 (en) * 2015-03-10 2016-09-15 Rhodes Technologies Acetate salt of buprenorphine and methods for preparing buprenorphine

Also Published As

Publication number Publication date
EA201792014A1 (ru) 2018-01-31
KR20200045010A (ko) 2020-04-29
CN107660207B (zh) 2020-09-29
JP6660399B2 (ja) 2020-03-11
TWI699367B (zh) 2020-07-21
PH12017501641A1 (en) 2018-02-12
US10278967B2 (en) 2019-05-07
NZ735736A (en) 2019-02-22
US20190314364A1 (en) 2019-10-17
US20180235955A1 (en) 2018-08-23
MA45902A (fr) 2019-06-19
CO2017009130A2 (es) 2017-11-21
AU2019203308A1 (en) 2019-05-30
CA3104099A1 (en) 2016-09-15
TW202037597A (zh) 2020-10-16
AU2016230750B2 (en) 2019-05-30
CN107660207A (zh) 2018-02-02
JP2018507882A (ja) 2018-03-22
MX2017011606A (es) 2017-10-26
CA2977732A1 (en) 2016-09-15
IL254384A0 (en) 2017-11-30
KR20170137738A (ko) 2017-12-13
US20180162866A1 (en) 2018-06-14
US10874662B2 (en) 2020-12-29
EP3283490A1 (en) 2018-02-21
US20170197975A1 (en) 2017-07-13
US20190298713A1 (en) 2019-10-03
US10406152B2 (en) 2019-09-10
US9926329B2 (en) 2018-03-27
TW201639856A (zh) 2016-11-16
WO2016142877A1 (en) 2016-09-15
CA2977732C (en) 2021-02-23
AU2016230750A1 (en) 2017-10-12
AR103902A1 (es) 2017-06-14
SG11201707350TA (en) 2017-10-30
US10835528B2 (en) 2020-11-17
US20210046066A1 (en) 2021-02-18
JP2020033359A (ja) 2020-03-05

Similar Documents

Publication Publication Date Title
BR112017019357A2 (pt) sal acetato de buprenorfina e métodos para preparar buprenorfina
CO2017012893A2 (es) Composiciones farmacéuticas que comprenden péptidos neo-antígenos o una sal de los mismos y métodos para preparar las mismas
EA201890123A1 (ru) Новые аминокислотные производные, способ их получения и фармацевтические композиции, содержащие их
BR112016015365A8 (pt) composto, composição farmacêutica e uso de um composto
UA118380C2 (uk) Заміщені сполуки дигідроізохінолінону
EP3176173A4 (en) Crystalline free bases of c-met inhibitor or crystalline acid salts thereof, and preparation methods and uses thereof
EA201790650A1 (ru) Лекарственная форма и способы применения абиратерона ацетата
EA201490756A1 (ru) Разагилина цитрамид
MX2018005520A (es) Metodos para preparacion de acido obeticolico y derivados de los mismos.
NI201700038A (es) Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo y usos de los mismos
BR112017009471A2 (pt) síntese de copanlisib e seu sal de di-hidrocloreto.
CY1123877T1 (el) Μορφες στερεας καταστασης αλατων νιλοτινιμπης
CL2015002712A1 (es) Cristales de laquinimod sódico y proceso para la preparación de ellos
EP3564224A3 (en) Crystalline form of vortioxetine hydrobromide as antidepressant drug
EP3263573A4 (en) Crystal of imidazo-oxazine, pharmaceutical composition containing said crystal, and method for producing said crystal
ZA202102783B (en) Novel salt of a bcl-2 inhibitor, related crystalline form, method for preparing the same and pharmaceutical compositions containing the same
MX2019003684A (es) Formas cristalinas de un derivado de acido biliar.
BR112016028083A2 (pt) Composição oral farmacêutica de isotretinoina e seu processo de preparação
BR112017008867A2 (pt) inibidores de proteína quinases
MX2016009667A (es) Forma cristalina alfa del compuesto a monobenzoato y método de preparación de la misma y composición farmacéutica que comprende la misma.
DK2612850T3 (da) Krystallinsk delta-form af argininsaltet af perindopril, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende dette
DK3398946T3 (da) Salt af morpholin-derivat og krystallin form deraf, samt fremstillingsfremgangsmåde, farmaceutisk sammensætning og anvendelse af samme
BR112016002724A2 (pt) composto, processo para a preparação de um composto, composição farmacêutica
EP3378479A4 (en) Method for preparing pharmaceutical composition comprising quinoline derivative or salt thereof
EP3159336A4 (en) Crystal of allisartan isoproxil, preparation method therefor and pharmaceutical composition containing same

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2661 DE 04-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.