TW202037597A - 用於製備丁基原啡因之方法 - Google Patents

用於製備丁基原啡因之方法 Download PDF

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Publication number
TW202037597A
TW202037597A TW109106564A TW109106564A TW202037597A TW 202037597 A TW202037597 A TW 202037597A TW 109106564 A TW109106564 A TW 109106564A TW 109106564 A TW109106564 A TW 109106564A TW 202037597 A TW202037597 A TW 202037597A
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TW
Taiwan
Prior art keywords
less
butylprophine
free base
acetate
blend
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TW109106564A
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English (en)
Chinese (zh)
Inventor
希 杭特利
艾瑞克 卡泰斯托
賀吉 瑞斯克
亞奇安納 夏瑪
加克 史迪密斯特
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美商羅德科技公司
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Application filed by 美商羅德科技公司 filed Critical 美商羅德科技公司
Publication of TW202037597A publication Critical patent/TW202037597A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW109106564A 2015-03-10 2016-03-10 用於製備丁基原啡因之方法 TW202037597A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562131114P 2015-03-10 2015-03-10
US62/131,114 2015-03-10

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TW202037597A true TW202037597A (zh) 2020-10-16

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TW105107434A TWI699367B (zh) 2015-03-10 2016-03-10 用於製備丁基原啡因之方法

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US (6) US10406152B2 (enExample)
EP (1) EP3283490A1 (enExample)
JP (2) JP6660399B2 (enExample)
KR (2) KR20170137738A (enExample)
CN (1) CN107660207B (enExample)
AR (1) AR103902A1 (enExample)
AU (2) AU2016230750B2 (enExample)
BR (1) BR112017019357A2 (enExample)
CA (2) CA2977732C (enExample)
CO (1) CO2017009130A2 (enExample)
EA (1) EA201792014A1 (enExample)
IL (1) IL254384A0 (enExample)
MA (1) MA45902A (enExample)
MX (1) MX2017011606A (enExample)
NZ (1) NZ735736A (enExample)
PH (1) PH12017501641A1 (enExample)
SG (1) SG11201707350TA (enExample)
TW (2) TW202037597A (enExample)
WO (1) WO2016142877A1 (enExample)

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WO2016179296A1 (en) 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
CA2983445A1 (en) 2015-05-08 2016-11-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
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EA201792014A1 (ru) 2018-01-31
WO2016142877A1 (en) 2016-09-15
JP2018507882A (ja) 2018-03-22
US9926329B2 (en) 2018-03-27
CN107660207A (zh) 2018-02-02
KR20170137738A (ko) 2017-12-13
SG11201707350TA (en) 2017-10-30
US10835528B2 (en) 2020-11-17
CA2977732A1 (en) 2016-09-15
MX2017011606A (es) 2017-10-26
CA2977732C (en) 2021-02-23
KR20200045010A (ko) 2020-04-29
US10406152B2 (en) 2019-09-10
US20180162866A1 (en) 2018-06-14
AU2016230750B2 (en) 2019-05-30
EP3283490A1 (en) 2018-02-21
JP2020033359A (ja) 2020-03-05
CA3104099A1 (en) 2016-09-15
MA45902A (fr) 2019-06-19
AU2019203308A1 (en) 2019-05-30
US20190314364A1 (en) 2019-10-17
US20210046066A1 (en) 2021-02-18
NZ735736A (en) 2019-02-22
IL254384A0 (en) 2017-11-30
AU2016230750A1 (en) 2017-10-12
TWI699367B (zh) 2020-07-21
PH12017501641A1 (en) 2018-02-12
US20190298713A1 (en) 2019-10-03
BR112017019357A2 (pt) 2018-06-05
US10874662B2 (en) 2020-12-29
CO2017009130A2 (es) 2017-11-21
AR103902A1 (es) 2017-06-14
TW201639856A (zh) 2016-11-16
CN107660207B (zh) 2020-09-29
JP6660399B2 (ja) 2020-03-11
US20170197975A1 (en) 2017-07-13
US20180235955A1 (en) 2018-08-23
US10278967B2 (en) 2019-05-07

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