AR103902A1 - Métodos para preparar buprenorfina - Google Patents
Métodos para preparar buprenorfinaInfo
- Publication number
- AR103902A1 AR103902A1 ARP160100641A ARP160100641A AR103902A1 AR 103902 A1 AR103902 A1 AR 103902A1 AR P160100641 A ARP160100641 A AR P160100641A AR P160100641 A ARP160100641 A AR P160100641A AR 103902 A1 AR103902 A1 AR 103902A1
- Authority
- AR
- Argentina
- Prior art keywords
- salts
- peaks
- buprenorphine
- acetate
- impurities
- Prior art date
Links
- 229960001736 buprenorphine Drugs 0.000 title abstract 4
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 159000000021 acetate salts Chemical class 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- -1 Buprenorphine acetate salts Chemical class 0.000 abstract 1
- 229910016523 CuKa Inorganic materials 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131114P | 2015-03-10 | 2015-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR103902A1 true AR103902A1 (es) | 2017-06-14 |
Family
ID=55524412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160100641A AR103902A1 (es) | 2015-03-10 | 2016-03-10 | Métodos para preparar buprenorfina |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US10406152B2 (enExample) |
| EP (1) | EP3283490A1 (enExample) |
| JP (2) | JP6660399B2 (enExample) |
| KR (2) | KR20170137738A (enExample) |
| CN (1) | CN107660207B (enExample) |
| AR (1) | AR103902A1 (enExample) |
| AU (2) | AU2016230750B2 (enExample) |
| BR (1) | BR112017019357A2 (enExample) |
| CA (2) | CA2977732C (enExample) |
| CO (1) | CO2017009130A2 (enExample) |
| EA (1) | EA201792014A1 (enExample) |
| IL (1) | IL254384A0 (enExample) |
| MA (1) | MA45902A (enExample) |
| MX (1) | MX2017011606A (enExample) |
| NZ (1) | NZ735736A (enExample) |
| PH (1) | PH12017501641A1 (enExample) |
| SG (1) | SG11201707350TA (enExample) |
| TW (2) | TW202037597A (enExample) |
| WO (1) | WO2016142877A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3553177T1 (sl) | 2013-03-15 | 2021-03-31 | The Board Of Trustees Of The Leland Stanford Junior University | Mikrobi, ki proizvajajo benzilizokinolinske alkaloide (BIA), in postopka za pripravo in uporabo le-teh |
| EP3066207A1 (en) | 2013-11-04 | 2016-09-14 | The Board Of Trustees Of The University Of the Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
| CN107660207B (zh) | 2015-03-10 | 2020-09-29 | 罗德科技公司 | 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 |
| WO2016179296A1 (en) | 2015-05-04 | 2016-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
| CA2983445A1 (en) | 2015-05-08 | 2016-11-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of producing epimerases and benzylisoquinoline alkaloids |
| CN110114457A (zh) | 2016-10-18 | 2019-08-09 | 安思雅公司 | 产生去甲阿片类和nal-阿片类苄基异喹啉生物碱的方法 |
| WO2019028390A1 (en) | 2017-08-03 | 2019-02-07 | Antheia, Inc. | ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS |
| TWI838372B (zh) * | 2018-05-11 | 2024-04-11 | 昱展新藥生技股份有限公司 | 丁基原啡因衍生物之長效注射劑型及結晶型 |
| MX2021010797A (es) | 2019-03-08 | 2021-12-10 | Univ Leland Stanford Junior | Células hospederas no vegetales productoras de alcaloides del tropano (ta), y métodos de preparacion y uso de los mismos. |
| CA3260542A1 (en) * | 2022-06-24 | 2023-12-28 | Alar Pharmaceuticals Inc. | Stable pharmaceutical composition of buprenorphine, its preparation process, and its use. |
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| CA2002299A1 (en) * | 1988-11-10 | 1990-05-10 | Eugene G. Drust | Compositions for the transdermal delivery of buprenorphine salts |
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| CN107660207B (zh) * | 2015-03-10 | 2020-09-29 | 罗德科技公司 | 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 |
-
2016
- 2016-03-09 CN CN201680027202.2A patent/CN107660207B/zh not_active Expired - Fee Related
- 2016-03-09 KR KR1020177028535A patent/KR20170137738A/ko not_active Ceased
- 2016-03-09 NZ NZ735736A patent/NZ735736A/en not_active IP Right Cessation
- 2016-03-09 SG SG11201707350TA patent/SG11201707350TA/en unknown
- 2016-03-09 JP JP2017547399A patent/JP6660399B2/ja not_active Expired - Fee Related
- 2016-03-09 WO PCT/IB2016/051332 patent/WO2016142877A1/en not_active Ceased
- 2016-03-09 CA CA2977732A patent/CA2977732C/en not_active Expired - Fee Related
- 2016-03-09 CA CA3104099A patent/CA3104099A1/en not_active Abandoned
- 2016-03-09 EA EA201792014A patent/EA201792014A1/ru unknown
- 2016-03-09 US US15/507,453 patent/US10406152B2/en active Active
- 2016-03-09 AU AU2016230750A patent/AU2016230750B2/en not_active Ceased
- 2016-03-09 KR KR1020207011729A patent/KR20200045010A/ko not_active Ceased
- 2016-03-09 BR BR112017019357A patent/BR112017019357A2/pt not_active IP Right Cessation
- 2016-03-09 EP EP16709607.2A patent/EP3283490A1/en not_active Withdrawn
- 2016-03-09 MX MX2017011606A patent/MX2017011606A/es unknown
- 2016-03-09 MA MA045902A patent/MA45902A/fr unknown
- 2016-03-10 TW TW109106564A patent/TW202037597A/zh unknown
- 2016-03-10 TW TW105107434A patent/TWI699367B/zh not_active IP Right Cessation
- 2016-03-10 AR ARP160100641A patent/AR103902A1/es unknown
-
2017
- 2017-03-01 US US15/446,197 patent/US9926329B2/en active Active
- 2017-09-07 CO CONC2017/0009130A patent/CO2017009130A2/es unknown
- 2017-09-07 IL IL254384A patent/IL254384A0/en unknown
- 2017-09-08 PH PH12017501641A patent/PH12017501641A1/en unknown
-
2018
- 2018-02-12 US US15/894,520 patent/US10278967B2/en active Active
-
2019
- 2019-05-10 AU AU2019203308A patent/AU2019203308A1/en not_active Abandoned
- 2019-06-19 US US16/446,397 patent/US10874662B2/en active Active
- 2019-06-19 US US16/446,373 patent/US10835528B2/en active Active
- 2019-10-10 JP JP2019186901A patent/JP2020033359A/ja active Pending
-
2020
- 2020-10-29 US US17/084,588 patent/US20210046066A1/en not_active Abandoned
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