CL2016003048A1 - Analogos de panonina minimas sintesis y uso de los mismos. - Google Patents

Analogos de panonina minimas sintesis y uso de los mismos.

Info

Publication number
CL2016003048A1
CL2016003048A1 CL2016003048A CL2016003048A CL2016003048A1 CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1 CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1
Authority
CL
Chile
Prior art keywords
saponin
panonin
analogues
minimizes
synthesis
Prior art date
Application number
CL2016003048A
Other languages
English (en)
Inventor
David Y Gin
Eric K Chea
Alberto Fernandez-Tejada
Derek S Tan
Jason S Lewis
Jeffrey R Gardner
Nagavarakishore Pillarsetty
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CL2016003048A1 publication Critical patent/CL2016003048A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>Se describen análogos truncados de saponina triterpénica que contienen un trisacárido o éster tetrasacárido. También se describen composiciones farmacéuticas que comprenden análogos truncados de saponina y métodos sintéticos para producir la saponina truncada. Otro aspecto de la presente solicitud se refiere a un método para inmunizar un sujeto, que comprende administrar al sujeto la composición farmacéutica que comprende un análogo de saponina mínimo y un antígeno.</p>
CL2016003048A 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos. CL2016003048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462005302P 2014-05-30 2014-05-30

Publications (1)

Publication Number Publication Date
CL2016003048A1 true CL2016003048A1 (es) 2017-06-16

Family

ID=54699970

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003048A CL2016003048A1 (es) 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos.

Country Status (14)

Country Link
US (3) US10626137B2 (es)
EP (2) EP3929202A1 (es)
JP (2) JP6774943B2 (es)
KR (1) KR102424785B1 (es)
CN (2) CN106573951B (es)
AU (3) AU2015266624A1 (es)
CA (1) CA2950750C (es)
CL (1) CL2016003048A1 (es)
DK (1) DK3149015T3 (es)
ES (1) ES2887400T3 (es)
IL (3) IL290897B2 (es)
SG (2) SG10202106403QA (es)
WO (1) WO2015184451A1 (es)
ZA (4) ZA201608255B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3868771A1 (en) * 2008-04-08 2021-08-25 Sloan-Kettering Institute for Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
KR102424785B1 (ko) * 2014-05-30 2022-07-25 메모리얼 슬로안 케터링 캔서 센터 최소 사포닌 유사체, 이의 합성법 및 용도
JP6900385B2 (ja) * 2015-11-06 2021-07-07 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
EP3389669B1 (en) * 2015-12-17 2023-03-15 Memorial Sloan-Kettering Cancer Center Triterpene saponin variants, methods of synthesis and use thereof
IL269963B2 (en) * 2017-04-13 2024-09-01 Adjuvance Tech Inc Synthesis of triterpene saponins, intermediates and adjuvant combinations
US20200164065A1 (en) * 2017-04-25 2020-05-28 Adjuvance Technologies, Inc. Triterpene saponin analogues
CA3075822A1 (en) * 2017-10-16 2019-04-25 Adjuvance Technologies, Inc. Triterpene saponin analogues
CN114222750A (zh) * 2019-07-25 2022-03-22 萨普雷米科技有限公司 改善治疗窗的皂苷衍生物
CN114630671A (zh) * 2019-11-05 2022-06-14 佐剂技术公司 水痘带状疱疹
JP2023532680A (ja) 2020-06-24 2023-07-31 サプリーム テクノロジーズ，ベー．フェー． 改善された治療濃度域を有するサポニン誘導体
EP4429674A1 (en) * 2021-11-08 2024-09-18 Adjuvance Technologies, Inc. Adjuvant compounds and formulations
EP4190359A1 (en) 2021-12-03 2023-06-07 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
WO2023139145A1 (en) 2022-01-19 2023-07-27 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin-based adjuvants and vaccines
CN117244053B (zh) * 2023-10-16 2024-04-26 国药中生生物技术研究院有限公司 具有常春藤皂苷元-O-Ara结构的化合物的佐剂用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3868771A1 (en) * 2008-04-08 2021-08-25 Sloan-Kettering Institute for Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
US8883170B2 (en) * 2008-09-03 2014-11-11 Western Illinois University Research Foundation Adjuvant
CN103768078B (zh) 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
CN103265606B (zh) 2013-05-31 2015-04-01 徐江平 一种常春藤皂苷元酰胺衍生物及其制备方法及其应用
CN103694375B (zh) 2013-12-13 2016-10-05 北京大学 一种三萜-环糊精共价化合物及其制备方法和用途
KR102424785B1 (ko) * 2014-05-30 2022-07-25 메모리얼 슬로안 케터링 캔서 센터 최소 사포닌 유사체, 이의 합성법 및 용도
JP6900385B2 (ja) * 2015-11-06 2021-07-07 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
CA3075822A1 (en) * 2017-10-16 2019-04-25 Adjuvance Technologies, Inc. Triterpene saponin analogues

Also Published As

Publication number Publication date
CN106573951B (zh) 2020-09-11
AU2021245129A1 (en) 2021-11-04
SG10202106403QA (en) 2021-07-29
US10626137B2 (en) 2020-04-21
IL276674B (en) 2022-04-01
AU2019279971A1 (en) 2020-01-16
ZA201608255B (en) 2019-04-24
IL276674A (en) 2020-09-30
KR20170032241A (ko) 2017-03-22
DK3149015T3 (da) 2021-09-27
US11274116B2 (en) 2022-03-15
JP6774943B2 (ja) 2020-10-28
EP3929202A1 (en) 2021-12-29
EP3149015A4 (en) 2017-12-27
JP2017518374A (ja) 2017-07-06
AU2015266624A1 (en) 2016-12-15
US20170096444A1 (en) 2017-04-06
ZA202304795B (en) 2024-08-28
IL290897B1 (en) 2023-06-01
IL249196A0 (en) 2017-01-31
AU2019279971B2 (en) 2021-07-15
EP3149015B1 (en) 2021-07-21
EP3149015A1 (en) 2017-04-05
ES2887400T3 (es) 2021-12-22
SG11201610004PA (en) 2016-12-29
JP2021006570A (ja) 2021-01-21
ZA202003022B (en) 2023-10-25
AU2021245129B2 (en) 2023-12-07
KR102424785B1 (ko) 2022-07-25
CA2950750A1 (en) 2015-12-03
IL249196B (en) 2020-08-31
JP7145188B2 (ja) 2022-09-30
ZA201808005B (en) 2021-04-28
CA2950750C (en) 2023-01-10
WO2015184451A1 (en) 2015-12-03
US20220275017A1 (en) 2022-09-01
IL290897A (en) 2022-04-01
US20210070796A1 (en) 2021-03-11
CN112028951A (zh) 2020-12-04
CN106573951A (zh) 2017-04-19
IL290897B2 (en) 2023-10-01

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