CN107660207B - 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 - Google Patents

丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 Download PDF

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Publication number
CN107660207B
CN107660207B CN201680027202.2A CN201680027202A CN107660207B CN 107660207 B CN107660207 B CN 107660207B CN 201680027202 A CN201680027202 A CN 201680027202A CN 107660207 B CN107660207 B CN 107660207B
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China
Prior art keywords
buprenorphine
less
free base
acetate
blend
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Expired - Fee Related
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CN201680027202.2A
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English (en)
Chinese (zh)
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CN107660207A (zh
Inventor
C·弗雷德里克·M·亨特利
埃里克·韦恩·卡泰斯托
黑尔格·阿尔弗雷德·赖施
阿尔沙纳·夏尔马
亚克·拉里·斯蒂米斯特
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Rhodes Technologies Inc
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Rhodes Technologies Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201680027202.2A 2015-03-10 2016-03-09 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 Expired - Fee Related CN107660207B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562131114P 2015-03-10 2015-03-10
US62/131,114 2015-03-10
PCT/IB2016/051332 WO2016142877A1 (en) 2015-03-10 2016-03-09 Acetate salt of buprenorphine and methods for preparing buprenorphine

Publications (2)

Publication Number Publication Date
CN107660207A CN107660207A (zh) 2018-02-02
CN107660207B true CN107660207B (zh) 2020-09-29

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US (6) US10406152B2 (enExample)
EP (1) EP3283490A1 (enExample)
JP (2) JP6660399B2 (enExample)
KR (2) KR20170137738A (enExample)
CN (1) CN107660207B (enExample)
AR (1) AR103902A1 (enExample)
AU (2) AU2016230750B2 (enExample)
BR (1) BR112017019357A2 (enExample)
CA (2) CA2977732C (enExample)
CO (1) CO2017009130A2 (enExample)
EA (1) EA201792014A1 (enExample)
IL (1) IL254384A0 (enExample)
MA (1) MA45902A (enExample)
MX (1) MX2017011606A (enExample)
NZ (1) NZ735736A (enExample)
PH (1) PH12017501641A1 (enExample)
SG (1) SG11201707350TA (enExample)
TW (2) TW202037597A (enExample)
WO (1) WO2016142877A1 (enExample)

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SI3553177T1 (sl) 2013-03-15 2021-03-31 The Board Of Trustees Of The Leland Stanford Junior University Mikrobi, ki proizvajajo benzilizokinolinske alkaloide (BIA), in postopka za pripravo in uporabo le-teh
EP3066207A1 (en) 2013-11-04 2016-09-14 The Board Of Trustees Of The University Of the Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
CN107660207B (zh) 2015-03-10 2020-09-29 罗德科技公司 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法
WO2016179296A1 (en) 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
CA2983445A1 (en) 2015-05-08 2016-11-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
CN110114457A (zh) 2016-10-18 2019-08-09 安思雅公司 产生去甲阿片类和nal-阿片类苄基异喹啉生物碱的方法
WO2019028390A1 (en) 2017-08-03 2019-02-07 Antheia, Inc. ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
TWI838372B (zh) * 2018-05-11 2024-04-11 昱展新藥生技股份有限公司 丁基原啡因衍生物之長效注射劑型及結晶型
MX2021010797A (es) 2019-03-08 2021-12-10 Univ Leland Stanford Junior Células hospederas no vegetales productoras de alcaloides del tropano (ta), y métodos de preparacion y uso de los mismos.
CA3260542A1 (en) * 2022-06-24 2023-12-28 Alar Pharmaceuticals Inc. Stable pharmaceutical composition of buprenorphine, its preparation process, and its use.

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EA201792014A1 (ru) 2018-01-31
WO2016142877A1 (en) 2016-09-15
JP2018507882A (ja) 2018-03-22
US9926329B2 (en) 2018-03-27
CN107660207A (zh) 2018-02-02
KR20170137738A (ko) 2017-12-13
SG11201707350TA (en) 2017-10-30
US10835528B2 (en) 2020-11-17
CA2977732A1 (en) 2016-09-15
MX2017011606A (es) 2017-10-26
CA2977732C (en) 2021-02-23
KR20200045010A (ko) 2020-04-29
US10406152B2 (en) 2019-09-10
US20180162866A1 (en) 2018-06-14
AU2016230750B2 (en) 2019-05-30
EP3283490A1 (en) 2018-02-21
JP2020033359A (ja) 2020-03-05
CA3104099A1 (en) 2016-09-15
MA45902A (fr) 2019-06-19
AU2019203308A1 (en) 2019-05-30
US20190314364A1 (en) 2019-10-17
US20210046066A1 (en) 2021-02-18
NZ735736A (en) 2019-02-22
IL254384A0 (en) 2017-11-30
AU2016230750A1 (en) 2017-10-12
TWI699367B (zh) 2020-07-21
PH12017501641A1 (en) 2018-02-12
TW202037597A (zh) 2020-10-16
US20190298713A1 (en) 2019-10-03
BR112017019357A2 (pt) 2018-06-05
US10874662B2 (en) 2020-12-29
CO2017009130A2 (es) 2017-11-21
AR103902A1 (es) 2017-06-14
TW201639856A (zh) 2016-11-16
JP6660399B2 (ja) 2020-03-11
US20170197975A1 (en) 2017-07-13
US20180235955A1 (en) 2018-08-23
US10278967B2 (en) 2019-05-07

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