TWI689514B - 化合物、組合物及用於治療疾病之方法 - Google Patents

化合物、組合物及用於治療疾病之方法 Download PDF

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TWI689514B
TWI689514B TW106122757A TW106122757A TWI689514B TW I689514 B TWI689514 B TW I689514B TW 106122757 A TW106122757 A TW 106122757A TW 106122757 A TW106122757 A TW 106122757A TW I689514 B TWI689514 B TW I689514B
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alkyl
compound
aryl
cancer
pharmaceutically acceptable
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TW201805295A (zh
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拉德哈克里西南 P 埃伊爾
安珍妮尤路 希里
西莎拉梅伊爾 帕德曼亞伯汗
吉塔 米賀
勝華 周
斯理魯帕 查拉
雷蒙 H 吉米
迪龍 克萊瑞
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美商史貝羅威生物科學有限公司
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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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TW106122757A 2016-07-06 2017-07-06 化合物、組合物及用於治療疾病之方法 TWI689514B (zh)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201662359039P 2016-07-06 2016-07-06
US62/359,039 2016-07-06
US201662363118P 2016-07-15 2016-07-15
US62/363,118 2016-07-15
US201662403530P 2016-10-03 2016-10-03
US62/403,530 2016-10-03
US201662411424P 2016-10-21 2016-10-21
US62/411,424 2016-10-21
US201762444141P 2017-01-09 2017-01-09
US62/444,141 2017-01-09
US201762462679P 2017-02-23 2017-02-23
US62/462,679 2017-02-23
US201762470746P 2017-03-13 2017-03-13
US62/470,746 2017-03-13
US201762508846P 2017-05-19 2017-05-19
US62/508,846 2017-05-19

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TW201805295A TW201805295A (zh) 2018-02-16
TWI689514B true TWI689514B (zh) 2020-04-01

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EP (1) EP3481402A4 (enExample)
JP (3) JP7100227B2 (enExample)
KR (1) KR102569881B1 (enExample)
CN (1) CN109843302B (enExample)
AU (1) AU2017293781B2 (enExample)
CA (1) CA3029644A1 (enExample)
IL (1) IL264049B2 (enExample)
MX (2) MX392605B (enExample)
MY (1) MY199689A (enExample)
SG (1) SG11201811709WA (enExample)
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