TWI679976B - 低及免疫增強劑量之ｍｔｏｒ抑制劑及其用途 - Google Patents

低及免疫增強劑量之ｍｔｏｒ抑制劑及其用途 Download PDF

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TWI679976B
TWI679976B TW103139447A TW103139447A TWI679976B TW I679976 B TWI679976 B TW I679976B TW 103139447 A TW103139447 A TW 103139447A TW 103139447 A TW103139447 A TW 103139447A TW I679976 B TWI679976 B TW I679976B
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Taiwan
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rad001
immune
mtor
mtor inhibitor
cancer
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TW103139447A
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Chinese (zh)
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TW201609095A (zh
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瓊安 曼尼克
Joan Mannick
大衛 葛萊斯
David Glass
里昂 墨菲
Leon Murphy
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瑞士商諾華公司
Novartis Ag
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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TW103139447A 2013-11-13 2014-11-13 低及免疫增強劑量之ｍｔｏｒ抑制劑及其用途 TWI679976B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361903636P 2013-11-13 2013-11-13
US61/903,636 2013-11-13
US201462027121P 2014-07-21 2014-07-21
US62/027,121 2014-07-21
US201462052629P 2014-09-19 2014-09-19
US62/052,629 2014-09-19
US201462076142P 2014-11-06 2014-11-06
US62/076,142 2014-11-06

Publications (2)

Publication Number Publication Date
TW201609095A TW201609095A (zh) 2016-03-16
TWI679976B true TWI679976B (zh) 2019-12-21

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TW103139447A TWI679976B (zh) 2013-11-13 2014-11-13 低及免疫增強劑量之ｍｔｏｒ抑制劑及其用途

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US (4) US20150140036A1 (enExample)
EP (1) EP3068435A1 (enExample)
JP (2) JP2016537345A (enExample)
KR (1) KR20160084438A (enExample)
CN (1) CN105899232A (enExample)
AU (3) AU2014348657A1 (enExample)
BR (1) BR112016010716A8 (enExample)
CA (1) CA2929181A1 (enExample)
EA (1) EA201690987A1 (enExample)
MX (1) MX2016006316A (enExample)
TW (1) TWI679976B (enExample)
WO (1) WO2015073644A1 (enExample)

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JP2017528433A (ja) 2014-07-21 2017-09-28 ノバルティス アーゲー 低い免疫増強用量のｍＴＯＲ阻害剤とＣＡＲの組み合わせ
BR112017001242A2 (pt) 2014-07-21 2017-12-05 Novartis Ag tratamento de câncer usando um receptor antigênico quimérico a cd33
JP6919118B2 (ja) 2014-08-14 2021-08-18 ノバルティス アーゲー ＧＦＲα−４キメラ抗原受容体を用いる癌の治療
CN106973568B (zh) 2014-10-08 2021-07-23 诺华股份有限公司 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途
JP2017536347A (ja) * 2014-10-17 2017-12-07 ノバルティス アーゲー セリチニブとｅｇｆｒ阻害剤の組合せ
US11083725B2 (en) 2014-10-24 2021-08-10 St. Jude Children's Research Hospital Coordinated metabolic reprogramming in response to productive viral infections
WO2016066608A1 (en) * 2014-10-28 2016-05-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging
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