TWI671281B - 螺槳烷（ｐｒｏｐｅｌｌａｎｅ）衍生物及合成 - Google Patents

螺槳烷（ｐｒｏｐｅｌｌａｎｅ）衍生物及合成 Download PDF

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TWI671281B
TWI671281B TW104107323A TW104107323A TWI671281B TW I671281 B TWI671281 B TW I671281B TW 104107323 A TW104107323 A TW 104107323A TW 104107323 A TW104107323 A TW 104107323A TW I671281 B TWI671281 B TW I671281B
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optionally substituted
unsubstituted
alkyl
group
heteroaryl
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TW201542499A (zh
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凱文 杜安 班納
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美商薩諾皇家麥爾斯通有限責任公司
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
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    • C07C211/19—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings containing condensed ring systems
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
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    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
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    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
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    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
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    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/42—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C255/00—Carboxylic acid nitriles
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    • C07C255/64—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to oxygen atoms
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
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    • C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
TW104107323A 2014-03-07 2015-03-06 螺槳烷（ｐｒｏｐｅｌｌａｎｅ）衍生物及合成 TWI671281B (zh)

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US201461949733P 2014-03-07 2014-03-07
US61/949,733 2014-03-07

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TWI671281B true TWI671281B (zh) 2019-09-11

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US (1) US10654812B2 (enExample)
EP (1) EP3114107B1 (enExample)
JP (2) JP6741343B2 (enExample)
KR (1) KR102401840B1 (enExample)
CN (2) CN106232567B (enExample)
CA (1) CA2942144C (enExample)
TW (1) TWI671281B (enExample)
WO (1) WO2015134710A1 (enExample)

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WO2019241244A1 (en) * 2018-06-13 2019-12-19 Board Of Regents, The University Of Texas System Salts of bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease
CN109456332B (zh) * 2018-08-16 2021-11-26 北京理工大学 一种稳定的氮杂[3.3.3]螺桨烷卡宾及其制备方法
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US11560366B2 (en) 2019-10-21 2023-01-24 Board Of Regents, The University Of Texas System Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
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CN115397824B (zh) 2020-04-02 2024-10-22 吉利德科学公司 用于制备cot抑制剂化合物的方法
WO2022035622A1 (en) * 2020-08-14 2022-02-17 Board Of Regents, The University Of Texas System Catalytically enhanced production of aluminum chlorohydrates
CN113264843B (zh) * 2021-04-15 2022-09-27 台州学院 一种3-氨基二环[1.1.1]戊烷-1-羧酸酯类衍生物的合成方法
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