TWI639446B - 含有酸性羧甲基纖維素及結晶纖維素之崩解性粒子組成物以及含有該組成物之口腔內崩解錠劑 - Google Patents
含有酸性羧甲基纖維素及結晶纖維素之崩解性粒子組成物以及含有該組成物之口腔內崩解錠劑 Download PDFInfo
- Publication number
- TWI639446B TWI639446B TW102133612A TW102133612A TWI639446B TW I639446 B TWI639446 B TW I639446B TW 102133612 A TW102133612 A TW 102133612A TW 102133612 A TW102133612 A TW 102133612A TW I639446 B TWI639446 B TW I639446B
- Authority
- TW
- Taiwan
- Prior art keywords
- particle composition
- carboxymethyl cellulose
- cellulose
- disintegrating
- crystalline cellulose
- Prior art date
Links
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- 229920002134 Carboxymethyl cellulose Polymers 0.000 title claims abstract description 46
- 235000010948 carboxy methyl cellulose Nutrition 0.000 title claims abstract description 46
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims description 4
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 4
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 229920000447 polyanionic polymer Polymers 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 46
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- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
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- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Inorganic Chemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP2012-206897 | 2012-09-20 | ||
| JP2012206897 | 2012-09-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201417843A TW201417843A (zh) | 2014-05-16 |
| TWI639446B true TWI639446B (zh) | 2018-11-01 |
Family
ID=50341348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102133612A TWI639446B (zh) | 2012-09-20 | 2013-09-17 | 含有酸性羧甲基纖維素及結晶纖維素之崩解性粒子組成物以及含有該組成物之口腔內崩解錠劑 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10292934B2 (enExample) |
| EP (1) | EP2898899B1 (enExample) |
| JP (1) | JP6230539B2 (enExample) |
| KR (1) | KR102114487B1 (enExample) |
| CN (1) | CN104010663B (enExample) |
| IN (1) | IN2015DN02907A (enExample) |
| TW (1) | TWI639446B (enExample) |
| WO (1) | WO2014046035A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN07797A (enExample) | 2012-03-29 | 2015-05-15 | Daicel Corp | |
| CN105517576A (zh) * | 2013-07-06 | 2016-04-20 | 株式会社大赛璐 | 超速崩解片剂及其制备方法 |
| CN105555316B (zh) | 2013-09-27 | 2020-07-07 | 株式会社大赛璐 | 通过二阶段的湿式制粒工序制备的崩解性颗粒组合物及含有该组合物的口腔内崩解片剂 |
| US20160213619A1 (en) * | 2013-09-27 | 2016-07-28 | Daicel Corporation | Intraorally disintegrable tablet comprising disintegrable granular composition |
| JP2017226600A (ja) * | 2014-10-16 | 2017-12-28 | 株式会社ダイセル | 超速崩壊錠剤 |
| KR102377914B1 (ko) | 2014-11-24 | 2022-03-22 | 주식회사 다이셀 | 분쇄 유당 또는 조립 유당을 포함하는 붕해성 입자 조성물 |
| CN106999437A (zh) * | 2014-12-25 | 2017-08-01 | 株式会社大赛璐 | 超速崩解片剂及其制备方法 |
| TWI695722B (zh) * | 2015-06-29 | 2020-06-11 | 日商大賽璐股份有限公司 | 固態製劑之外層用組成物及含有該外層用組成物之易服用性固態製劑 |
| ES2607715B1 (es) | 2015-10-01 | 2018-01-17 | Solutex Na, Lcc | Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa |
| JP6697874B2 (ja) * | 2015-12-25 | 2020-05-27 | 日本製紙パピリア株式会社 | 成形材料及び成形品 |
| EP3406241A4 (en) * | 2016-01-18 | 2019-06-26 | Daicel Corporation | INTRAORAL RESISTANT DISTILLANT SOLUBLE PREPARATION, METHOD FOR THE MANUFACTURE THEREOF, AND POWDER COMPOSITION USED IN THE SAID MANUFACTURING METHOD |
| JP2019156723A (ja) * | 2018-03-07 | 2019-09-19 | 大原薬品工業株式会社 | 圧縮成形性に優れた賦形剤を用いる、浸透膨潤型口腔内崩壊錠 |
| JP7036856B2 (ja) * | 2019-03-28 | 2022-03-15 | 日本ケミファ株式会社 | 口腔内崩壊錠 |
| EP4056638A4 (en) | 2019-11-07 | 2022-11-30 | Asahi Kasei Kabushiki Kaisha | COMPOSITION OF CELLULOSE, TABLET AND ORODISPERSIBLE TABLET |
| WO2021099531A1 (en) | 2019-11-22 | 2021-05-27 | Biohorm, S.L. | Zonisamide orodispersible tablets |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000273039A (ja) * | 1999-01-20 | 2000-10-03 | Taisho Pharmaceut Co Ltd | 口腔内崩壊性組成物 |
| US20040033258A1 (en) * | 2000-10-06 | 2004-02-19 | Masahiko Koike | Solid preparations |
| CN102006861A (zh) * | 2008-02-13 | 2011-04-06 | 大日本住友制药株式会社 | 口腔崩解片 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2851453A (en) | 1954-08-09 | 1958-09-09 | Smith Kline French Lab | Cellulose derivative product, compositions comprising the same and their preparation |
| JPH10182436A (ja) | 1996-10-31 | 1998-07-07 | Takeda Chem Ind Ltd | 固形医薬製剤 |
| JP2000290172A (ja) * | 1999-04-09 | 2000-10-17 | Earth Chem Corp Ltd | 発泡タブレット |
| JP4284017B2 (ja) * | 2000-10-06 | 2009-06-24 | 武田薬品工業株式会社 | 固形製剤 |
| JP4551627B2 (ja) | 2003-02-28 | 2010-09-29 | 東和薬品株式会社 | 口腔内崩壊錠剤の製造方法 |
| EP1923074A4 (en) | 2005-08-10 | 2011-09-14 | Shionogi & Co | TABLET WHICH CAN BE ORALLY DISINTEGRATED |
| JP5123517B2 (ja) | 2005-11-14 | 2013-01-23 | 帝人ファーマ株式会社 | アンブロキソール口腔内速崩性錠剤 |
| JP5766899B2 (ja) | 2007-04-11 | 2015-08-19 | ニプロ株式会社 | 口腔内崩壊剤及びその製造方法 |
| JP2008285434A (ja) | 2007-05-16 | 2008-11-27 | Taisho Pharm Ind Ltd | 口腔内速崩壊錠 |
| CA2686964A1 (en) | 2007-06-06 | 2008-12-11 | Basf Se | Pharmaceutical formulation for the production of rapidly disintegrating tablets |
| WO2011019045A1 (ja) | 2009-08-11 | 2011-02-17 | 富士化学工業株式会社 | 崩壊性粒子組成物及び口腔内速崩壊錠 |
| US8591955B2 (en) * | 2009-08-11 | 2013-11-26 | Dainippon Sumitomo Pharma Co., Ltd. | Orally rapidly disintegrating tablet that contains two or more types of particles |
| US20110150989A1 (en) | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
| JP6073543B2 (ja) | 2010-07-08 | 2017-02-01 | 沢井製薬株式会社 | ロラタジン含有口腔内崩壊錠の製造方法 |
| JP6245677B2 (ja) * | 2012-01-20 | 2017-12-13 | ニプロ株式会社 | 口腔内崩壊錠 |
| IN2014DN07797A (enExample) | 2012-03-29 | 2015-05-15 | Daicel Corp |
-
2013
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- 2013-09-13 CN CN201380004424.9A patent/CN104010663B/zh active Active
- 2013-09-17 TW TW102133612A patent/TWI639446B/zh active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000273039A (ja) * | 1999-01-20 | 2000-10-03 | Taisho Pharmaceut Co Ltd | 口腔内崩壊性組成物 |
| US20040033258A1 (en) * | 2000-10-06 | 2004-02-19 | Masahiko Koike | Solid preparations |
| CN102006861A (zh) * | 2008-02-13 | 2011-04-06 | 大日本住友制药株式会社 | 口腔崩解片 |
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| CN104010663B (zh) | 2021-02-19 |
| JPWO2014046035A1 (ja) | 2016-08-18 |
| WO2014046035A1 (ja) | 2014-03-27 |
| JP6230539B2 (ja) | 2017-11-15 |
| EP2898899A4 (en) | 2016-03-16 |
| KR102114487B1 (ko) | 2020-05-22 |
| EP2898899A1 (en) | 2015-07-29 |
| TW201417843A (zh) | 2014-05-16 |
| CN104010663A (zh) | 2014-08-27 |
| IN2015DN02907A (enExample) | 2015-09-11 |
| US10292934B2 (en) | 2019-05-21 |
| EP2898899B1 (en) | 2019-09-11 |
| KR20150056636A (ko) | 2015-05-26 |
| US20150238424A1 (en) | 2015-08-27 |
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