TWI631949B - 使用tor激酶抑制劑組合療法以治療癌症之方法 - Google Patents
使用tor激酶抑制劑組合療法以治療癌症之方法 Download PDFInfo
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- TWI631949B TWI631949B TW103113963A TW103113963A TWI631949B TW I631949 B TWI631949 B TW I631949B TW 103113963 A TW103113963 A TW 103113963A TW 103113963 A TW103113963 A TW 103113963A TW I631949 B TWI631949 B TW I631949B
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- Prior art keywords
- pyridine
- benzo
- dihydropyridine
- methyl
- pyridin
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| WO2014172436A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
| KR102221029B1 (ko) | 2013-04-17 | 2021-02-26 | 시그날 파마소티칼 엘엘씨 | 디하이드로피라지노-피라진을 사용한 암의 치료 |
| EA037683B1 (ru) | 2013-04-17 | 2021-04-29 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Фармацевтические составы, способы, твердые формы и способы применения, относящиеся к 1-этил-7-(2-метил-6-(1h-1,2,4-триазол-3-ил)пиридин-3-ил)-3,4-дигидропиразино[2,3-b] пиразин-2(1h)-ону |
| CN105407892B (zh) | 2013-05-29 | 2019-05-07 | 西格诺药品有限公司 | 一种化合物的药物组合物、其固体形式及它们的使用方法 |
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| WO2015160868A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
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| CN115813928B (zh) * | 2022-09-16 | 2025-03-11 | 厦门大学 | 一种精氨酸甲基转移酶prmt1抑制剂及其应用 |
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2014
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- 2014-04-16 KR KR1020157029902A patent/KR102242505B1/ko active Active
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- 2014-04-16 TW TW103113963A patent/TWI631949B/zh active
- 2014-04-16 CN CN201480034607.XA patent/CN105392499B/zh active Active
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- 2014-04-16 EP EP14725327.2A patent/EP2986321A1/en not_active Withdrawn
- 2014-04-16 HK HK16109193.8A patent/HK1221144A1/zh unknown
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2015
- 2015-10-07 ZA ZA2015/07450A patent/ZA201507450B/en unknown
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|---|---|---|---|---|
| CN102245611A (zh) * | 2008-10-27 | 2011-11-16 | 西格诺药品有限公司 | 用于与 mTOR/PI3K/AKT/途径相关的肿瘤适应症和疾病的 mTOR激酶抑制剂 |
| WO2010093435A1 (en) * | 2009-02-10 | 2010-08-19 | Celgene International Sarl | Methods for treating non-small cell lung cancer using 5-azacytidine |
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| CA2908742C (en) | 2021-06-01 |
| MX374749B (es) | 2025-03-06 |
| AU2014254059B2 (en) | 2019-06-06 |
| JP6382948B2 (ja) | 2018-08-29 |
| KR102242505B1 (ko) | 2021-04-20 |
| AU2014254059A1 (en) | 2015-11-19 |
| IL242021B (en) | 2020-01-30 |
| TW201526895A (zh) | 2015-07-16 |
| US9782427B2 (en) | 2017-10-10 |
| JP2016516820A (ja) | 2016-06-09 |
| CA2908742A1 (en) | 2014-10-23 |
| EP2986321A1 (en) | 2016-02-24 |
| BR112015026247A8 (pt) | 2019-12-24 |
| ZA201507450B (en) | 2017-01-25 |
| BR112015026247A2 (pt) | 2017-07-25 |
| HK1221144A1 (zh) | 2017-05-26 |
| MX2015014599A (es) | 2016-03-03 |
| KR20160002782A (ko) | 2016-01-08 |
| BR112015026247B1 (pt) | 2022-08-23 |
| CN105392499B (zh) | 2018-07-24 |
| NZ631082A (en) | 2017-06-30 |
| US20140315848A1 (en) | 2014-10-23 |
| CN105392499A (zh) | 2016-03-09 |
| WO2014172432A1 (en) | 2014-10-23 |
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