TWI609962B - 細胞培養基之病毒過濾 - Google Patents

細胞培養基之病毒過濾 Download PDF

Info

Publication number
TWI609962B
TWI609962B TW102121710A TW102121710A TWI609962B TW I609962 B TWI609962 B TW I609962B TW 102121710 A TW102121710 A TW 102121710A TW 102121710 A TW102121710 A TW 102121710A TW I609962 B TWI609962 B TW I609962B
Authority
TW
Taiwan
Prior art keywords
virus
filtration
cell culture
filter
culture medium
Prior art date
Application number
TW102121710A
Other languages
English (en)
Chinese (zh)
Other versions
TW201412986A (zh
Inventor
Wolfgang Mundt
沃夫岡 孟德
Artur Mitterer
阿特 密特瑞
Manfred Reiter
曼福烈 萊特
Meinhard Hasslacher
曼哈德 赫斯拉雀爾
Leopold Grillberger
李奧波 葛里柏格
Thomas Kreil
湯瑪士 克萊爾
Original Assignee
Baxalta Incorporated
巴克斯歐塔公司
Baxalta GmbH
巴克斯歐塔有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Incorporated, 巴克斯歐塔公司, Baxalta GmbH, 巴克斯歐塔有限公司 filed Critical Baxalta Incorporated
Publication of TW201412986A publication Critical patent/TW201412986A/zh
Application granted granted Critical
Publication of TWI609962B publication Critical patent/TWI609962B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Filtering Materials (AREA)
TW102121710A 2012-06-21 2013-06-19 細胞培養基之病毒過濾 TWI609962B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261662814P 2012-06-21 2012-06-21
US61/662,814 2012-06-21

Publications (2)

Publication Number Publication Date
TW201412986A TW201412986A (zh) 2014-04-01
TWI609962B true TWI609962B (zh) 2018-01-01

Family

ID=48672845

Family Applications (2)

Application Number Title Priority Date Filing Date
TW102121710A TWI609962B (zh) 2012-06-21 2013-06-19 細胞培養基之病毒過濾
TW106136343A TWI698522B (zh) 2012-06-21 2013-06-19 細胞培養基之病毒過濾

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW106136343A TWI698522B (zh) 2012-06-21 2013-06-19 細胞培養基之病毒過濾

Country Status (27)

Country Link
US (3) US9670456B2 (enExample)
EP (2) EP2732020B1 (enExample)
JP (3) JP6220392B2 (enExample)
KR (2) KR20190092618A (enExample)
CN (2) CN104640969A (enExample)
AR (1) AR092847A1 (enExample)
AU (2) AU2013277532B2 (enExample)
BR (1) BR112014031842B1 (enExample)
CA (1) CA2876473C (enExample)
CO (1) CO7151484A2 (enExample)
DK (2) DK2732020T3 (enExample)
EA (2) EA201990887A1 (enExample)
ES (2) ES2829968T3 (enExample)
HR (1) HRP20161435T1 (enExample)
HU (1) HUE031601T2 (enExample)
IL (2) IL236073B (enExample)
IN (1) IN2014DN10441A (enExample)
MX (2) MX386767B (enExample)
MY (2) MY173835A (enExample)
NZ (1) NZ629083A (enExample)
PL (2) PL3103861T3 (enExample)
PT (2) PT3103861T (enExample)
SG (2) SG10201701721TA (enExample)
SI (1) SI2732020T1 (enExample)
TW (2) TWI609962B (enExample)
WO (1) WO2013192009A1 (enExample)
ZA (1) ZA201409253B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014031842B1 (pt) * 2012-06-21 2020-09-15 Baxalta GmbH Método para remover um contaminante viral de uma preparação
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
SG10201507931QA (en) * 2014-12-22 2016-07-28 Emd Millipore Corp Removal of microorganisms from cell culture media
JP7133925B2 (ja) 2015-03-23 2022-09-09 アレクシオン ファーマシューティカルズ インコーポレイテッド ウイルス濾過
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
WO2017180814A1 (en) * 2016-04-15 2017-10-19 Boehringer Ingelheim International Gmbh Cell retention device and method
EP3535047A1 (en) * 2016-12-09 2019-09-11 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
BR112020000127A2 (pt) * 2017-07-06 2020-07-07 Regeneron Pharmaceuticals, Inc. método para selecionar um hidrolisado de soja, e, glicoproteína
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US11504713B2 (en) 2019-03-11 2022-11-22 Genzyme Corporation Tangential viral filtration
US11912741B2 (en) * 2019-04-03 2024-02-27 Genzyme Corporation Continuous production of recombinant proteins
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
WO2021231956A1 (en) * 2020-05-14 2021-11-18 North Carolina State University Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
IL301774A (en) * 2020-10-02 2023-05-01 Regeneron Pharma Continuous retentive filtering of viruses
WO2025019797A2 (en) * 2023-07-19 2025-01-23 Hatchless Inc. System and method for low-cost sterilization of liquids

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1457497A1 (en) * 2003-03-06 2004-09-15 Probitas Pharma, S.A. Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process
EP1775016A1 (en) * 2005-10-14 2007-04-18 Millipore Corporation Ultrafiltration membranes rendered hydrophilic by hydroxyalkyl cellulose and method of making and use of such membranes

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0422874A (ja) * 1990-05-16 1992-01-27 Matsushita Electric Ind Co Ltd 波形表示装置
GB2352652A (en) 1999-08-06 2001-02-07 Fsm Technologies Ltd Pre-treating hollow fibre membranes for micro-organism detection
US6485686B1 (en) * 1999-09-17 2002-11-26 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for counting submicron sized particles
WO2001040448A1 (en) 1999-12-02 2001-06-07 The General Hospital Corporation Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US6485688B1 (en) 2000-04-24 2002-11-26 General Electric Company On-line sparging sampling and monitoring systems and methods
US6835311B2 (en) 2002-01-31 2004-12-28 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
JP4874806B2 (ja) * 2003-12-01 2012-02-15 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 液体因子ｖｉｉ組成物のウイルス濾過
DE102005047301B4 (de) * 2005-09-30 2009-04-16 Sartorius Stedim Biotech Gmbh Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen
US8309029B1 (en) * 2009-03-26 2012-11-13 The United States Of America As Represented By The Secretary Of The Army Virus and particulate separation from solution
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
DK2467399T3 (en) * 2009-08-20 2017-01-23 Baxalta Inc Purification of vWF for increased removal of non-lipid-enveloped viruses
BR112014031842B1 (pt) * 2012-06-21 2020-09-15 Baxalta GmbH Método para remover um contaminante viral de uma preparação

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1457497A1 (en) * 2003-03-06 2004-09-15 Probitas Pharma, S.A. Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process
EP1775016A1 (en) * 2005-10-14 2007-04-18 Millipore Corporation Ultrafiltration membranes rendered hydrophilic by hydroxyalkyl cellulose and method of making and use of such membranes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Liu S et al., "Development and Qualification of a Novel Virus Removal Filter for Cell Culture Applications", Biotechnol. Prog., vol.16, p.425-434, 2000/03/05 *

Also Published As

Publication number Publication date
AU2013277532B2 (en) 2017-06-15
IN2014DN10441A (enExample) 2015-08-21
SI2732020T1 (sl) 2017-03-31
EA201590059A1 (ru) 2015-04-30
CO7151484A2 (es) 2014-12-29
US20170260498A1 (en) 2017-09-14
EP3103861A1 (en) 2016-12-14
TW201816105A (zh) 2018-05-01
AR092847A1 (es) 2015-05-06
TWI698522B (zh) 2020-07-11
WO2013192009A1 (en) 2013-12-27
PL2732020T3 (pl) 2017-06-30
US9670456B2 (en) 2017-06-06
HRP20161435T1 (hr) 2017-02-24
IL236073B (en) 2019-01-31
CN104640969A (zh) 2015-05-20
PT2732020T (pt) 2016-11-10
US20200277565A1 (en) 2020-09-03
KR20150032709A (ko) 2015-03-27
EP2732020B1 (en) 2016-08-10
JP2017184765A (ja) 2017-10-12
EP2732020A1 (en) 2014-05-21
JP2019022526A (ja) 2019-02-14
HK1231502A1 (en) 2017-12-22
TW201412986A (zh) 2014-04-01
DK2732020T3 (en) 2016-11-28
IL263479B (en) 2020-08-31
AU2017228547B2 (en) 2019-02-21
ES2829968T3 (es) 2021-06-02
CN108795724A (zh) 2018-11-13
ZA201409253B (en) 2022-05-25
BR112014031842B1 (pt) 2020-09-15
CA2876473A1 (en) 2013-12-27
HK1198335A1 (zh) 2015-04-02
SG10201701721TA (en) 2017-04-27
AU2017228547A1 (en) 2017-10-05
HUE031601T2 (hu) 2017-07-28
JP6557706B2 (ja) 2019-08-07
PT3103861T (pt) 2020-11-16
US20130344535A1 (en) 2013-12-26
CA2876473C (en) 2021-05-11
JP2015529447A (ja) 2015-10-08
DK3103861T3 (da) 2020-11-16
MX2014015950A (es) 2015-07-17
IL263479A (en) 2019-01-31
KR20190092618A (ko) 2019-08-07
MX386767B (es) 2025-03-19
AU2013277532A1 (en) 2015-01-15
ES2601429T3 (es) 2017-02-15
MY173835A (en) 2020-02-24
BR112014031842A2 (pt) 2017-08-22
SG11201408490PA (en) 2015-01-29
US11421202B2 (en) 2022-08-23
PL3103861T3 (pl) 2021-03-22
EA201990887A1 (ru) 2019-08-30
EA033006B1 (ru) 2019-08-30
JP6220392B2 (ja) 2017-10-25
MY195362A (en) 2023-01-16
EP3103861B1 (en) 2020-09-30
IL236073A0 (en) 2015-01-29
KR102008048B1 (ko) 2019-08-06
MX347319B (es) 2017-04-21
NZ629083A (en) 2016-11-25

Similar Documents

Publication Publication Date Title
TWI609962B (zh) 細胞培養基之病毒過濾
AU2015217006A1 (en) Ultrafiltration unit for continuous buffer or media exchange from a protein solution
RU2461629C2 (ru) Среды для культур клеток млекопитающих, которые содержат надосадочную жидкость стадий фракционирования по кону, и их применение
Kleindienst et al. Virus risk mitigation in cell culture media
US11052165B2 (en) Method for virus clearance
HK1231502B (en) Virus filtration of cell culture media
KR102817858B1 (ko) 베로 세포 배양용 저혈청 배지 조성물 및 이의 이용
HK1198335B (en) Virus filtration of cell culture media
EA042527B1 (ru) Вирусная фильтрация сред клеточных культур
Nikolay Intensified yellow fever and Zika virus production in animal cell culture
Gränicher Process intensification and integration for the production of vaccines and viral vectors
Durrani et al. Non-animal peptone for serum free cultivation of recombinant mammalian and animal cells
Vázquez Ramírez Process intensification for the production of MVA and influenza A virus in high density suspension cultures of AGE1. CR. pIX cells
CN121773128A (zh) 用于无菌过滤含白蛋白水溶液的方法