SG11201408490PA - Virus filtration of cell culture media - Google Patents
Virus filtration of cell culture mediaInfo
- Publication number
- SG11201408490PA SG11201408490PA SG11201408490PA SG11201408490PA SG11201408490PA SG 11201408490P A SG11201408490P A SG 11201408490PA SG 11201408490P A SG11201408490P A SG 11201408490PA SG 11201408490P A SG11201408490P A SG 11201408490PA SG 11201408490P A SG11201408490P A SG 11201408490PA
- Authority
- SG
- Singapore
- Prior art keywords
- cell culture
- international
- culture medium
- vienna
- filtration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0017—Filtration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/02—Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Filtering Materials (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/192009 A1 (51) International Patent Classification: C12M1/00 (2006.01) C12M1/12 (2006.01) A61L 2/00 (2006.01) CI2N 5/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/662,814 21 June 2012 (21.06.2012) (74) Agent: BRIVANLOU, Margaret; King & Spalding LLP, 1185 Avenue of the Americas, New York, New York 10036 (US). PCT/US2013/045663 13 June 2013 (13.06.2013) English (71) Applicants: BAXTER INTERNATIONAL INC. [US/US]; One Baxter Parkway, Deerfield, Illinois 60015 (US). BAXTER HEALTHCARE S.A. [CH/CH]; Thur- gauerstrasse 130, CH-8152 Glattpark (Opfikon) (CH). (72) Inventors; and (71) Applicants MUNDT, : Wolfgang [AT/AT]; Florianigasse 57/1/2/6, A-1080 Vienna (AT). MITTERER, Artur [AT/AT]; Schwarzeckerweg 10, A-2304 Orth/Donau (AT). REITER, Manfred [AT/AT]; Gebrueder-Lang-Gasse 11/17, A-1150 Vienna (AT). HASSLACHER, Meinhard [AT/AT]; Vorgartenstrasse 221/1/7, A-1020 Vienna (AT). GRILLBERGER, Leopold [AT/AT]; Finsterergasse la, A-1220 Vienna (AT). KREIL, Thomas [AT/AT]; Ziegel- ofengasse 93-95, A-3400 Klosterneuburg (AT). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, us SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 0\ © o CJ o\ i-H cn i-H o CJ o & (54) Title: VIRUS FILTRATION OF CELL CULTURE MEDIA (57) Abstract: The invention relates to a method for removing a viral contaminant from preparation, being a a cell culture medium or least at a component of cell a culture medium. The method comprises subjecting said preparation filtration to for at least about 24 hours through a virus filter having an effective pore size of maximum about 75 nm. Further, the invention relates to the use of a virus filter in filtration of at least about 24 hours, wherein the virus filter has an effective pore size of maximum about 75 nm for the re moval of viral contaminant from a preparation, being a cell culture medium or at least component a of a cell culture medium. In some embodiments the filtration according to the invention operates at a volumetric capacity of at least about 2000 L/m2. Further, the invention relates to the use of a preparation, being a cell culture medium or at least a component of a cell culture medium obtain - able according to method of the invention for cell culture; pharmaceutical, diagnostic and/or cosmetic preparations as well as in food preparations.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662814P | 2012-06-21 | 2012-06-21 | |
| PCT/US2013/045663 WO2013192009A1 (en) | 2012-06-21 | 2013-06-13 | Virus filtration of cell culture media |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201408490PA true SG11201408490PA (en) | 2015-01-29 |
Family
ID=48672845
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201701721TA SG10201701721TA (en) | 2012-06-21 | 2013-06-13 | Virus filtration of cell culture media |
| SG11201408490PA SG11201408490PA (en) | 2012-06-21 | 2013-06-13 | Virus filtration of cell culture media |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201701721TA SG10201701721TA (en) | 2012-06-21 | 2013-06-13 | Virus filtration of cell culture media |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US9670456B2 (en) |
| EP (2) | EP3103861B1 (en) |
| JP (3) | JP6220392B2 (en) |
| KR (2) | KR20190092618A (en) |
| CN (2) | CN108795724A (en) |
| AR (1) | AR092847A1 (en) |
| AU (2) | AU2013277532B2 (en) |
| BR (1) | BR112014031842B1 (en) |
| CA (1) | CA2876473C (en) |
| CO (1) | CO7151484A2 (en) |
| DK (2) | DK3103861T3 (en) |
| EA (2) | EA201990887A1 (en) |
| ES (2) | ES2601429T3 (en) |
| HK (2) | HK1198335A1 (en) |
| HR (1) | HRP20161435T1 (en) |
| HU (1) | HUE031601T2 (en) |
| IL (2) | IL236073B (en) |
| IN (1) | IN2014DN10441A (en) |
| MX (1) | MX347319B (en) |
| MY (2) | MY173835A (en) |
| NZ (1) | NZ629083A (en) |
| PL (2) | PL2732020T3 (en) |
| PT (2) | PT3103861T (en) |
| SG (2) | SG10201701721TA (en) |
| SI (1) | SI2732020T1 (en) |
| TW (2) | TWI698522B (en) |
| WO (1) | WO2013192009A1 (en) |
| ZA (1) | ZA201409253B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE031601T2 (en) * | 2012-06-21 | 2017-07-28 | Baxalta GmbH | Virus filtration of cell culture media |
| AR095196A1 (en) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | SERUM FREE CELL CULTIVATION MEDIA |
| SG10201507931QA (en) * | 2014-12-22 | 2016-07-28 | Emd Millipore Corp | Removal of microorganisms from cell culture media |
| WO2016154290A1 (en) | 2015-03-23 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | Virus filtration |
| EP3015542A1 (en) * | 2015-05-07 | 2016-05-04 | Bayer Technology Services GmbH | Modular system and method for continuous, germ reduced production and/or processing of a product |
| TW202340452A (en) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | Taurine supplemented cell culture medium and methods of use |
| US20190169559A1 (en) * | 2016-04-15 | 2019-06-06 | Boehringer Ingelheim International Gmbh | Cell retention device and method |
| EP3535047A1 (en) * | 2016-12-09 | 2019-09-11 | Lonza Ltd | Method for the reduction of viral titer in pharmaceuticals |
| CA3067847A1 (en) * | 2017-07-06 | 2019-01-10 | Regeneron Pharmaceuticals, Inc. | Cell culture process for making a glycoprotein |
| WO2019213567A1 (en) * | 2018-05-04 | 2019-11-07 | Genzyme Corporation | Perfusion bioreactor with filtration systems |
| TW202100248A (en) | 2019-03-11 | 2021-01-01 | 美商健臻公司 | Tangential viral filtration |
| WO2021231956A1 (en) * | 2020-05-14 | 2021-11-18 | North Carolina State University | Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues |
| WO2022072899A1 (en) * | 2020-10-02 | 2022-04-07 | Regeneron Pharmaceuticals, Inc. | Continuous virus retentive filtration |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0422874A (en) * | 1990-05-16 | 1992-01-27 | Matsushita Electric Ind Co Ltd | Waveform display device |
| GB2352652A (en) * | 1999-08-06 | 2001-02-07 | Fsm Technologies Ltd | Pre-treating hollow fibre membranes for micro-organism detection |
| US6485686B1 (en) * | 1999-09-17 | 2002-11-26 | The United States Of America As Represented By The Secretary Of The Army | Method and apparatus for counting submicron sized particles |
| WO2001040448A1 (en) | 1999-12-02 | 2001-06-07 | The General Hospital Corporation | Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon |
| US6485688B1 (en) | 2000-04-24 | 2002-11-26 | General Electric Company | On-line sparging sampling and monitoring systems and methods |
| US6630016B2 (en) * | 2002-01-31 | 2003-10-07 | Koslow Technologies Corp. | Microporous filter media, filtration systems containing same, and methods of making and using |
| US6835311B2 (en) * | 2002-01-31 | 2004-12-28 | Koslow Technologies Corporation | Microporous filter media, filtration systems containing same, and methods of making and using |
| ES2214967B1 (en) | 2003-03-06 | 2005-06-16 | Probitas Pharma, S.A | PROCEDURE FOR THE ELIMINATION OF VIRUSES IN FIBRINOGEN AND FIBRINOGEN SOLUTIONS OBTAINED BY SUCH PROCEDURE. |
| AU2004294403A1 (en) * | 2003-12-01 | 2005-06-16 | Novo Nordisk Health Care Ag | Nanofiltration of factor VII solutions to remove virus |
| DE102005047301B4 (en) * | 2005-09-30 | 2009-04-16 | Sartorius Stedim Biotech Gmbh | Method for detection of virus depletion for the validation of filters and filtration processes |
| US20070084788A1 (en) * | 2005-10-14 | 2007-04-19 | Millipore Corporation | Ultrafiltration membranes and methods of making and use of ultrafiltration membranes |
| US8309029B1 (en) * | 2009-03-26 | 2012-11-13 | The United States Of America As Represented By The Secretary Of The Army | Virus and particulate separation from solution |
| US8945895B2 (en) * | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| JP5838159B2 (en) * | 2009-08-20 | 2015-12-24 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | Purification of VWF to enhance removal of non-lipid enveloped virus |
| HUE031601T2 (en) * | 2012-06-21 | 2017-07-28 | Baxalta GmbH | Virus filtration of cell culture media |
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2013
- 2013-06-13 HU HUE13731015A patent/HUE031601T2/en unknown
- 2013-06-13 DK DK16181886.9T patent/DK3103861T3/en active
- 2013-06-13 WO PCT/US2013/045663 patent/WO2013192009A1/en active Application Filing
- 2013-06-13 BR BR112014031842-5A patent/BR112014031842B1/en active IP Right Grant
- 2013-06-13 MY MYPI2014003498A patent/MY173835A/en unknown
- 2013-06-13 MY MYPI2018000283A patent/MY195362A/en unknown
- 2013-06-13 PT PT161818869T patent/PT3103861T/en unknown
- 2013-06-13 ES ES13731015.7T patent/ES2601429T3/en active Active
- 2013-06-13 PT PT137310157T patent/PT2732020T/en unknown
- 2013-06-13 ES ES16181886T patent/ES2829968T3/en active Active
- 2013-06-13 IN IN10441DEN2014 patent/IN2014DN10441A/en unknown
- 2013-06-13 SI SI201330369A patent/SI2732020T1/en unknown
- 2013-06-13 EA EA201990887A patent/EA201990887A1/en unknown
- 2013-06-13 DK DK13731015.7T patent/DK2732020T3/en active
- 2013-06-13 PL PL13731015T patent/PL2732020T3/en unknown
- 2013-06-13 MX MX2014015950A patent/MX347319B/en active IP Right Grant
- 2013-06-13 NZ NZ629083A patent/NZ629083A/en unknown
- 2013-06-13 KR KR1020197022413A patent/KR20190092618A/en not_active Application Discontinuation
- 2013-06-13 CN CN201810569534.4A patent/CN108795724A/en active Pending
- 2013-06-13 KR KR1020157001269A patent/KR102008048B1/en active IP Right Grant
- 2013-06-13 AU AU2013277532A patent/AU2013277532B2/en active Active
- 2013-06-13 SG SG10201701721TA patent/SG10201701721TA/en unknown
- 2013-06-13 CN CN201380032998.7A patent/CN104640969A/en active Pending
- 2013-06-13 EA EA201590059A patent/EA033006B1/en not_active IP Right Cessation
- 2013-06-13 EP EP16181886.9A patent/EP3103861B1/en active Active
- 2013-06-13 EP EP13731015.7A patent/EP2732020B1/en active Active
- 2013-06-13 CA CA2876473A patent/CA2876473C/en active Active
- 2013-06-13 JP JP2015518459A patent/JP6220392B2/en active Active
- 2013-06-13 SG SG11201408490PA patent/SG11201408490PA/en unknown
- 2013-06-13 PL PL16181886.9T patent/PL3103861T3/en unknown
- 2013-06-19 TW TW106136343A patent/TWI698522B/en active
- 2013-06-19 AR ARP130102198A patent/AR092847A1/en active IP Right Grant
- 2013-06-19 US US13/921,417 patent/US9670456B2/en active Active
- 2013-06-19 TW TW102121710A patent/TWI609962B/en active
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2014
- 2014-11-19 HK HK14111690.4A patent/HK1198335A1/en unknown
- 2014-12-04 IL IL236073A patent/IL236073B/en active IP Right Grant
- 2014-12-15 ZA ZA2014/09253A patent/ZA201409253B/en unknown
- 2014-12-17 CO CO14277524A patent/CO7151484A2/en unknown
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2016
- 2016-11-02 HR HRP20161435TT patent/HRP20161435T1/en unknown
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2017
- 2017-03-27 US US15/470,064 patent/US20170260498A1/en not_active Abandoned
- 2017-05-23 HK HK17105198.0A patent/HK1231502A1/en unknown
- 2017-07-13 JP JP2017137031A patent/JP6557706B2/en not_active Expired - Fee Related
- 2017-09-12 AU AU2017228547A patent/AU2017228547B2/en active Active
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2018
- 2018-11-14 JP JP2018213613A patent/JP2019022526A/en not_active Withdrawn
- 2018-12-04 IL IL263479A patent/IL263479B/en active IP Right Grant
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2020
- 2020-03-12 US US16/816,641 patent/US11421202B2/en active Active
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