SG11201811446SA - Process for recovering viral products using functionalised chromatography media - Google Patents
Process for recovering viral products using functionalised chromatography mediaInfo
- Publication number
- SG11201811446SA SG11201811446SA SG11201811446SA SG11201811446SA SG11201811446SA SG 11201811446S A SG11201811446S A SG 11201811446SA SG 11201811446S A SG11201811446S A SG 11201811446SA SG 11201811446S A SG11201811446S A SG 11201811446SA SG 11201811446S A SG11201811446S A SG 11201811446SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- viral
- product
- viruses
- cores
- Prior art date
Links
- 230000003612 virological effect Effects 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 4
- 239000012501 chromatography medium Substances 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 abstract 6
- 239000002245 particle Substances 0.000 abstract 3
- 210000000234 capsid Anatomy 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 210000002845 virion Anatomy 0.000 abstract 2
- 241000581479 Apodichthys Species 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000002023 wood Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28023—Fibres or filaments
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
- B01J20/28038—Membranes or mats made from fibers or filaments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
- B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 011111111101 11111111111111 111E1111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/011599 A3 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: C12N 7/02 (2006.01) C12N 7/00 (2006.01) Published: 1301.1 20/285 (2006.01) A61K 48/00 (2006.01) — with international search report (Art 21(3)) — before the expiration of the time limit for amending the (21) International Application Number: claims and to be republished in the event of receipt of PCT/GB2017/052084 amendments (Rule 48.2(h)) (22) International Filing Date: (88) Date of publication of the international search report: 14 July 2017 (14.07.2017) 15 February 2018 (15.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1612248.3 14 July 2016 (14.07.2016) GB (71) Applicant: PURIDIFY LTD. [GB/GB]; Stevenage Bio- science Catalyst, Gunnels Wood Road, Stevenage Hertford- shire SG1 2FX (GB). (72) Inventor: SCANLON, Ian; 21 Hayfield Avenue, Sawston Cambridgeshire CB22 3JZ (GB). Agent: NEWMAN, Alastair James Morley; 14 South (74) Square, Gray's Inn, London Greater London WC1R 5JJ (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NE NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) = Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) M ON (54) Title: PROCESS FOR RECOVERING VIRAL PRODUCTS USING FUNCTIONALISED CHROMATOGRAPHY MEDIA 01 in (57) : The present invention provides a process for recovering a viral product from a composition comprising said product 1-1 and product-related impurities, which process comprises contacting the composition with a functionalised chromatography medium 1 8 comprising one or more polymer nanofibres, wherein the viral product comprises a plurality of viruses, virus particles/virions, viral ---. cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed, or proviruses, each of which GC ., contains one or more polynucleotides, and wherein the product-related impurities comprise a plurality of viruses, virus particles/virions, 1:::: ) virus-like particles, viral cores, membrane-stripped viruses, viral cores with outer membrane(s) removed and/or capsids removed or N proviruses, each of which is substantially devoid of polynucleotides. O
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1612248.3A GB201612248D0 (en) | 2016-07-14 | 2016-07-14 | New process |
PCT/GB2017/052084 WO2018011599A2 (en) | 2016-07-14 | 2017-07-14 | Process for recovering viral products using functionalised chromatography media |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201811446SA true SG11201811446SA (en) | 2019-01-30 |
Family
ID=56890529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811446SA SG11201811446SA (en) | 2016-07-14 | 2017-07-14 | Process for recovering viral products using functionalised chromatography media |
Country Status (7)
Country | Link |
---|---|
US (1) | US11103853B2 (en) |
EP (1) | EP3485003B1 (en) |
JP (1) | JP7139004B2 (en) |
CN (1) | CN109415707A (en) |
GB (1) | GB201612248D0 (en) |
SG (1) | SG11201811446SA (en) |
WO (1) | WO2018011599A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019530737A (en) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | Compositions and methods for treating non-aged hearing loss in human subjects |
JP7385095B2 (en) * | 2019-03-22 | 2023-11-22 | ナガセケムテックス株式会社 | Nucleic acid adsorbent |
AU2021225035A1 (en) | 2020-02-21 | 2022-10-13 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
GB202006231D0 (en) * | 2020-04-28 | 2020-06-10 | Puridify Ltd | Seperation matrix and metod for seperation |
SI3957378T1 (en) * | 2020-08-18 | 2023-07-31 | Sartorius BIA Separations D.O.O | Multimodal metal affinity processing aav capsids |
US20230294017A1 (en) * | 2020-08-18 | 2023-09-21 | Sartorius Bia Separations D.O.O. | Multimodal metal affinity processing aav capsids |
CN112246222B (en) * | 2020-10-22 | 2021-06-01 | 军事科学院军事医学研究院环境医学与作业医学研究所 | Virus enrichment material, preparation method and application thereof, virus enrichment system and application thereof |
GB202202713D0 (en) * | 2022-02-28 | 2022-04-13 | Cytiva Bioprocess R & D Ab | Method of preparing a functionalised chromatography medium |
GB202214187D0 (en) | 2022-09-28 | 2022-11-09 | Puridify Ltd | A stationary phase for use in affinity chromatography |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2625279A1 (en) | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
AU3418900A (en) * | 1999-03-26 | 2000-10-16 | Upfront Chromatography A/S | Fluidised bed purification of bio-macromolecules such as plasmid dna, chromosomal dna, rna, viral dna, bacteria and viruses |
US20040106184A1 (en) * | 2002-08-28 | 2004-06-03 | Introgen Therapeutics Inc. | Chromatographic methods for adenovirus purification |
PT1625210E (en) | 2003-05-21 | 2011-03-15 | Genzyme Corp | Methods for producing preparations of recombinant aav virions substantially free of empty capsids |
GB0515577D0 (en) | 2005-07-29 | 2005-09-07 | Amersham Biosciences Ab | Process for cross-linking cellulose ester membranes |
JP2007117003A (en) | 2005-10-28 | 2007-05-17 | Nippon Pall Kk | Method for rapidly removing and purifying hollow virus particle |
GB0702504D0 (en) | 2007-02-09 | 2007-03-21 | Ge Healthcare Bio Sciences Ab | Cross-linked cellulose membranes |
JP2010193720A (en) | 2009-02-23 | 2010-09-09 | Asahi Kasei Chemicals Corp | Method for separating virus using porous membrane having immobilized anion exchange group |
HUE028341T2 (en) | 2009-06-16 | 2016-12-28 | Genzyme Corp | Improved methods for purification of recombinant aav vectors |
EP2488635B1 (en) | 2009-10-15 | 2013-11-20 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
CN105838737A (en) | 2010-01-28 | 2016-08-10 | 费城儿童医院 | A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy |
WO2011154976A2 (en) | 2010-06-08 | 2011-12-15 | Panacea Biotec Limited | Improved influenza vaccine |
KR101871683B1 (en) | 2010-07-30 | 2018-06-27 | 이엠디 밀리포어 코포레이션 | Chromatogrphy media and method |
GB201119192D0 (en) * | 2011-11-07 | 2011-12-21 | Ucl Business Plc | Chromatography medium |
WO2015052460A1 (en) * | 2013-10-09 | 2015-04-16 | Ucl Business Plc | Chromatography medium |
JP6409528B2 (en) * | 2014-11-27 | 2018-10-24 | Jnc株式会社 | Porous cellulose particles having an ion exchange group containing amino groups and a hydrophobic group containing butyl groups, a chromatography carrier containing the same, and a method for purifying virus-like particles of hepatitis B virus |
-
2016
- 2016-07-14 GB GBGB1612248.3A patent/GB201612248D0/en not_active Ceased
-
2017
- 2017-07-14 US US16/314,943 patent/US11103853B2/en active Active
- 2017-07-14 JP JP2019500819A patent/JP7139004B2/en active Active
- 2017-07-14 EP EP17742287.0A patent/EP3485003B1/en active Active
- 2017-07-14 WO PCT/GB2017/052084 patent/WO2018011599A2/en unknown
- 2017-07-14 SG SG11201811446SA patent/SG11201811446SA/en unknown
- 2017-07-14 CN CN201780043253.9A patent/CN109415707A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN109415707A (en) | 2019-03-01 |
JP2019527058A (en) | 2019-09-26 |
GB201612248D0 (en) | 2016-08-31 |
US11103853B2 (en) | 2021-08-31 |
WO2018011599A2 (en) | 2018-01-18 |
WO2018011599A3 (en) | 2018-02-15 |
JP7139004B2 (en) | 2022-09-20 |
EP3485003B1 (en) | 2020-10-14 |
US20190255513A1 (en) | 2019-08-22 |
EP3485003A2 (en) | 2019-05-22 |
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