JP6220392B2 - 細胞培養培地のウイルスろ過 - Google Patents

細胞培養培地のウイルスろ過 Download PDF

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Publication number
JP6220392B2
JP6220392B2 JP2015518459A JP2015518459A JP6220392B2 JP 6220392 B2 JP6220392 B2 JP 6220392B2 JP 2015518459 A JP2015518459 A JP 2015518459A JP 2015518459 A JP2015518459 A JP 2015518459A JP 6220392 B2 JP6220392 B2 JP 6220392B2
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Prior art keywords
filtration
virus
filter
cell culture
viral
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JP2015518459A
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Japanese (ja)
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JP2015529447A5 (enExample
JP2015529447A (ja
Inventor
ヴォルフガンク ムント，
ヴォルフガンク ムント，
アルトゥル ミッテラー，
アルトゥル ミッテラー，
マンフレート ライター，
マンフレート ライター，
マインハルト ハッスラッカー，
マインハルト ハッスラッカー，
レオポルト グリルベルガー，
レオポルト グリルベルガー，
トマス クライル，
トマス クライル，
Original Assignee
バクスアルタ ゲーエムベーハー
バクスアルタ ゲーエムベーハー
バクスアルタ インコーポレイテッド
バクスアルタ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Filtering Materials (AREA)
JP2015518459A 2012-06-21 2013-06-13 細胞培養培地のウイルスろ過 Active JP6220392B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662814P 2012-06-21 2012-06-21
US61/662,814 2012-06-21
PCT/US2013/045663 WO2013192009A1 (en) 2012-06-21 2013-06-13 Virus filtration of cell culture media

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017137031A Division JP6557706B2 (ja) 2012-06-21 2017-07-13 細胞培養培地のウイルスろ過

Publications (3)

Publication Number Publication Date
JP2015529447A JP2015529447A (ja) 2015-10-08
JP2015529447A5 JP2015529447A5 (enExample) 2016-09-15
JP6220392B2 true JP6220392B2 (ja) 2017-10-25

Family

ID=48672845

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015518459A Active JP6220392B2 (ja) 2012-06-21 2013-06-13 細胞培養培地のウイルスろ過
JP2017137031A Expired - Fee Related JP6557706B2 (ja) 2012-06-21 2017-07-13 細胞培養培地のウイルスろ過
JP2018213613A Withdrawn JP2019022526A (ja) 2012-06-21 2018-11-14 細胞培養培地のウイルスろ過

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017137031A Expired - Fee Related JP6557706B2 (ja) 2012-06-21 2017-07-13 細胞培養培地のウイルスろ過
JP2018213613A Withdrawn JP2019022526A (ja) 2012-06-21 2018-11-14 細胞培養培地のウイルスろ過

Country Status (27)

Country Link
US (3) US9670456B2 (enExample)
EP (2) EP3103861B1 (enExample)
JP (3) JP6220392B2 (enExample)
KR (2) KR102008048B1 (enExample)
CN (2) CN108795724A (enExample)
AR (1) AR092847A1 (enExample)
AU (2) AU2013277532B2 (enExample)
BR (1) BR112014031842B1 (enExample)
CA (1) CA2876473C (enExample)
CO (1) CO7151484A2 (enExample)
DK (2) DK2732020T3 (enExample)
EA (2) EA033006B1 (enExample)
ES (2) ES2601429T3 (enExample)
HR (1) HRP20161435T1 (enExample)
HU (1) HUE031601T2 (enExample)
IL (2) IL236073B (enExample)
IN (1) IN2014DN10441A (enExample)
MX (2) MX386767B (enExample)
MY (2) MY195362A (enExample)
NZ (1) NZ629083A (enExample)
PL (2) PL3103861T3 (enExample)
PT (2) PT3103861T (enExample)
SG (2) SG10201701721TA (enExample)
SI (1) SI2732020T1 (enExample)
TW (2) TWI698522B (enExample)
WO (1) WO2013192009A1 (enExample)
ZA (1) ZA201409253B (enExample)

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MY195362A (en) * 2012-06-21 2023-01-16 Baxalta Inc Virus Filtration of Cell Culture Media
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
SG10201507931QA (en) * 2014-12-22 2016-07-28 Emd Millipore Corp Removal of microorganisms from cell culture media
WO2016154290A1 (en) * 2015-03-23 2016-09-29 Alexion Pharmaceuticals, Inc. Virus filtration
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
SG11201809051YA (en) * 2016-04-15 2018-11-29 Boehringer Ingelheim Int Cell retention device and method
WO2018107099A1 (en) * 2016-12-09 2018-06-14 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
MX2020000228A (es) * 2017-07-06 2020-08-10 Regeneron Pharma Proceso de cultivo celular para producir una glicoproteina.
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
MX2021010891A (es) * 2019-03-11 2021-12-10 Genzyme Corp Filtracion tangencial de virus.
AU2020253381A1 (en) * 2019-04-03 2021-12-02 Genzyme Corporation Continuous production of recombinant proteins
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
US20230181796A1 (en) * 2020-05-14 2023-06-15 North Carolina State University Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
CA3197305A1 (en) * 2020-10-02 2022-04-07 Regeneron Pharmaceuticals, Inc. Continuous virus retentive filtration
WO2025019797A2 (en) * 2023-07-19 2025-01-23 Hatchless Inc. System and method for low-cost sterilization of liquids

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JPH0422874A (ja) * 1990-05-16 1992-01-27 Matsushita Electric Ind Co Ltd 波形表示装置
GB2352652A (en) 1999-08-06 2001-02-07 Fsm Technologies Ltd Pre-treating hollow fibre membranes for micro-organism detection
US6485686B1 (en) * 1999-09-17 2002-11-26 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for counting submicron sized particles
AU1811301A (en) 1999-12-02 2001-06-12 General Hospital Corporation, The Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US6485688B1 (en) 2000-04-24 2002-11-26 General Electric Company On-line sparging sampling and monitoring systems and methods
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
US6835311B2 (en) * 2002-01-31 2004-12-28 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
ES2214967B1 (es) * 2003-03-06 2005-06-16 Probitas Pharma, S.A Procedimiento para la eliminacion de virus en soluciones de fibrinogeno y fibrinogeno obtenido por dicho procedimiento.
PL1711513T3 (pl) * 2003-12-01 2014-12-31 Novo Nordisk Healthcare Ag Nanofiltracja roztworów czynnika vii w celu usunięcia wirusów
DE102005047301B4 (de) * 2005-09-30 2009-04-16 Sartorius Stedim Biotech Gmbh Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen
US20070084788A1 (en) * 2005-10-14 2007-04-19 Millipore Corporation Ultrafiltration membranes and methods of making and use of ultrafiltration membranes
US8309029B1 (en) * 2009-03-26 2012-11-13 The United States Of America As Represented By The Secretary Of The Army Virus and particulate separation from solution
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
SG10201408106WA (en) * 2009-08-20 2015-01-29 Baxter Int Purification of vwf for increased removal of non-lipid enveloped viruses
MY195362A (en) * 2012-06-21 2023-01-16 Baxalta Inc Virus Filtration of Cell Culture Media

Also Published As

Publication number Publication date
EA201590059A1 (ru) 2015-04-30
SG10201701721TA (en) 2017-04-27
TW201816105A (zh) 2018-05-01
CA2876473C (en) 2021-05-11
IL263479B (en) 2020-08-31
HRP20161435T1 (hr) 2017-02-24
ES2829968T3 (es) 2021-06-02
IN2014DN10441A (enExample) 2015-08-21
KR102008048B1 (ko) 2019-08-06
MX347319B (es) 2017-04-21
CA2876473A1 (en) 2013-12-27
MY173835A (en) 2020-02-24
PT2732020T (pt) 2016-11-10
BR112014031842B1 (pt) 2020-09-15
TWI698522B (zh) 2020-07-11
NZ629083A (en) 2016-11-25
WO2013192009A1 (en) 2013-12-27
EP2732020B1 (en) 2016-08-10
MX2014015950A (es) 2015-07-17
IL263479A (en) 2019-01-31
AR092847A1 (es) 2015-05-06
EP3103861A1 (en) 2016-12-14
SI2732020T1 (sl) 2017-03-31
US20200277565A1 (en) 2020-09-03
JP2017184765A (ja) 2017-10-12
TWI609962B (zh) 2018-01-01
JP6557706B2 (ja) 2019-08-07
HUE031601T2 (hu) 2017-07-28
US20170260498A1 (en) 2017-09-14
PT3103861T (pt) 2020-11-16
ZA201409253B (en) 2022-05-25
AU2017228547B2 (en) 2019-02-21
KR20150032709A (ko) 2015-03-27
HK1231502A1 (en) 2017-12-22
EP2732020A1 (en) 2014-05-21
JP2015529447A (ja) 2015-10-08
BR112014031842A2 (pt) 2017-08-22
CO7151484A2 (es) 2014-12-29
AU2013277532B2 (en) 2017-06-15
EA033006B1 (ru) 2019-08-30
EP3103861B1 (en) 2020-09-30
IL236073B (en) 2019-01-31
US20130344535A1 (en) 2013-12-26
US9670456B2 (en) 2017-06-06
PL2732020T3 (pl) 2017-06-30
ES2601429T3 (es) 2017-02-15
JP2019022526A (ja) 2019-02-14
DK2732020T3 (en) 2016-11-28
US11421202B2 (en) 2022-08-23
EA201990887A1 (ru) 2019-08-30
PL3103861T3 (pl) 2021-03-22
SG11201408490PA (en) 2015-01-29
TW201412986A (zh) 2014-04-01
KR20190092618A (ko) 2019-08-07
CN108795724A (zh) 2018-11-13
MX386767B (es) 2025-03-19
AU2013277532A1 (en) 2015-01-15
AU2017228547A1 (en) 2017-10-05
MY195362A (en) 2023-01-16
IL236073A0 (en) 2015-01-29
HK1198335A1 (zh) 2015-04-02
DK3103861T3 (da) 2020-11-16
CN104640969A (zh) 2015-05-20

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