EA033006B1 - Способ удаления вирусного контаминанта из клеточной культуральной среды - Google Patents

Способ удаления вирусного контаминанта из клеточной культуральной среды

Info

Publication number
EA033006B1
EA033006B1 EA201590059A EA201590059A EA033006B1 EA 033006 B1 EA033006 B1 EA 033006B1 EA 201590059 A EA201590059 A EA 201590059A EA 201590059 A EA201590059 A EA 201590059A EA 033006 B1 EA033006 B1 EA 033006B1
Authority
EA
Eurasian Patent Office
Prior art keywords
contaminant
cultural environment
cell cultural
viral
virus contaminant
Prior art date
Application number
EA201590059A
Other languages
English (en)
Russian (ru)
Other versions
EA201590059A1 (ru
Inventor
Вольфганг Мундт
Артур Миттерер
Манфред Райтер
Майнхард Хасслахер
Леопольд Грилльбергер
Томас Крайль
Original Assignee
Баксалта Инкорпорейтид
Баксалта Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Баксалта Инкорпорейтид, Баксалта Гмбх filed Critical Баксалта Инкорпорейтид
Publication of EA201590059A1 publication Critical patent/EA201590059A1/ru
Publication of EA033006B1 publication Critical patent/EA033006B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Filtering Materials (AREA)
EA201590059A 2012-06-21 2013-06-13 Способ удаления вирусного контаминанта из клеточной культуральной среды EA033006B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261662814P 2012-06-21 2012-06-21
PCT/US2013/045663 WO2013192009A1 (en) 2012-06-21 2013-06-13 Virus filtration of cell culture media

Publications (2)

Publication Number Publication Date
EA201590059A1 EA201590059A1 (ru) 2015-04-30
EA033006B1 true EA033006B1 (ru) 2019-08-30

Family

ID=48672845

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201590059A EA033006B1 (ru) 2012-06-21 2013-06-13 Способ удаления вирусного контаминанта из клеточной культуральной среды
EA201990887A EA201990887A1 (ru) 2012-06-21 2013-06-13 Вирусная фильтрация сред клеточных культур

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201990887A EA201990887A1 (ru) 2012-06-21 2013-06-13 Вирусная фильтрация сред клеточных культур

Country Status (27)

Country Link
US (3) US9670456B2 (enExample)
EP (2) EP2732020B1 (enExample)
JP (3) JP6220392B2 (enExample)
KR (2) KR20190092618A (enExample)
CN (2) CN104640969A (enExample)
AR (1) AR092847A1 (enExample)
AU (2) AU2013277532B2 (enExample)
BR (1) BR112014031842B1 (enExample)
CA (1) CA2876473C (enExample)
CO (1) CO7151484A2 (enExample)
DK (2) DK3103861T3 (enExample)
EA (2) EA033006B1 (enExample)
ES (2) ES2829968T3 (enExample)
HR (1) HRP20161435T1 (enExample)
HU (1) HUE031601T2 (enExample)
IL (2) IL236073B (enExample)
IN (1) IN2014DN10441A (enExample)
MX (2) MX386767B (enExample)
MY (2) MY195362A (enExample)
NZ (1) NZ629083A (enExample)
PL (2) PL2732020T3 (enExample)
PT (2) PT3103861T (enExample)
SG (2) SG10201701721TA (enExample)
SI (1) SI2732020T1 (enExample)
TW (2) TWI698522B (enExample)
WO (1) WO2013192009A1 (enExample)
ZA (1) ZA201409253B (enExample)

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WO2013192009A1 (en) * 2012-06-21 2013-12-27 Baxter International Inc. Virus filtration of cell culture media
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
SG10201507931QA (en) * 2014-12-22 2016-07-28 Emd Millipore Corp Removal of microorganisms from cell culture media
ES2936088T3 (es) * 2015-03-23 2023-03-14 Alexion Pharma Inc Filtración de virus
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
WO2017180814A1 (en) * 2016-04-15 2017-10-19 Boehringer Ingelheim International Gmbh Cell retention device and method
US11034721B2 (en) * 2016-12-09 2021-06-15 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
KR20210084695A (ko) * 2017-07-06 2021-07-07 리제너론 파마슈티칼스 인코포레이티드 당단백질을 만들기 위한 세포 배양 과정
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
WO2020185825A1 (en) * 2019-03-11 2020-09-17 Genzyme Corporation Tangential viral filtration
CN113825840A (zh) * 2019-04-03 2021-12-21 建新公司 重组蛋白的连续生产
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
WO2021231956A1 (en) * 2020-05-14 2021-11-18 North Carolina State University Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
JP2023544163A (ja) * 2020-10-02 2023-10-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 連続的なウイルス捕捉濾過
WO2025019797A2 (en) * 2023-07-19 2025-01-23 Hatchless Inc. System and method for low-cost sterilization of liquids

Citations (3)

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EP0457497A2 (en) * 1990-05-16 1991-11-21 Matsushita Electric Industrial Co., Ltd. Waveform displaying device
US7144533B2 (en) * 2002-01-31 2006-12-05 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
EP1775016A1 (en) * 2005-10-14 2007-04-18 Millipore Corporation Ultrafiltration membranes rendered hydrophilic by hydroxyalkyl cellulose and method of making and use of such membranes

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GB2352652A (en) 1999-08-06 2001-02-07 Fsm Technologies Ltd Pre-treating hollow fibre membranes for micro-organism detection
US6485686B1 (en) * 1999-09-17 2002-11-26 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for counting submicron sized particles
US6861001B2 (en) 1999-12-02 2005-03-01 The General Hospital Corporation Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US6485688B1 (en) 2000-04-24 2002-11-26 General Electric Company On-line sparging sampling and monitoring systems and methods
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
ES2214967B1 (es) * 2003-03-06 2005-06-16 Probitas Pharma, S.A Procedimiento para la eliminacion de virus en soluciones de fibrinogeno y fibrinogeno obtenido por dicho procedimiento.
AU2004294403A1 (en) 2003-12-01 2005-06-16 Novo Nordisk Health Care Ag Nanofiltration of factor VII solutions to remove virus
DE102005047301B4 (de) * 2005-09-30 2009-04-16 Sartorius Stedim Biotech Gmbh Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen
US8309029B1 (en) * 2009-03-26 2012-11-13 The United States Of America As Represented By The Secretary Of The Army Virus and particulate separation from solution
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
MX2012002129A (es) * 2009-08-20 2012-06-08 Baxter Int Purificacion del factor de von willebrand (vwf) para remocion incrementada de virus envueltos sin lipido.
WO2013192009A1 (en) * 2012-06-21 2013-12-27 Baxter International Inc. Virus filtration of cell culture media

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0457497A2 (en) * 1990-05-16 1991-11-21 Matsushita Electric Industrial Co., Ltd. Waveform displaying device
US7144533B2 (en) * 2002-01-31 2006-12-05 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
EP1775016A1 (en) * 2005-10-14 2007-04-18 Millipore Corporation Ultrafiltration membranes rendered hydrophilic by hydroxyalkyl cellulose and method of making and use of such membranes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHENGJIANG LIU, MARK CARROLL, RAQUEL IVERSON, CHRISTINE VALERA, JOANN VENNARI, KIMBERLY TURCO, ROBERT PIPER, ROBERT KISS, HERBERT : "Development and Quantification of a Novel Virus Removal Filter for Cell Culture Applications", BIOTECHNOLOGY PROGRESS, AMERICAN CHEMICAL SOCIETY, vol. 16, no. 3, 3 May 2000 (2000-05-03), pages 425 - 434, XP002711823, ISSN: 8756-7938, DOI: 10.1021/BP000027M *

Also Published As

Publication number Publication date
MX386767B (es) 2025-03-19
HK1231502A1 (en) 2017-12-22
BR112014031842B1 (pt) 2020-09-15
US11421202B2 (en) 2022-08-23
BR112014031842A2 (pt) 2017-08-22
JP2015529447A (ja) 2015-10-08
JP2019022526A (ja) 2019-02-14
WO2013192009A1 (en) 2013-12-27
PT3103861T (pt) 2020-11-16
MX2014015950A (es) 2015-07-17
IL263479A (en) 2019-01-31
HRP20161435T1 (hr) 2017-02-24
KR20150032709A (ko) 2015-03-27
TW201816105A (zh) 2018-05-01
HUE031601T2 (hu) 2017-07-28
TW201412986A (zh) 2014-04-01
US20200277565A1 (en) 2020-09-03
AU2013277532B2 (en) 2017-06-15
EA201590059A1 (ru) 2015-04-30
CN104640969A (zh) 2015-05-20
SG10201701721TA (en) 2017-04-27
EP3103861A1 (en) 2016-12-14
CN108795724A (zh) 2018-11-13
AR092847A1 (es) 2015-05-06
EP3103861B1 (en) 2020-09-30
SG11201408490PA (en) 2015-01-29
US20130344535A1 (en) 2013-12-26
AU2017228547B2 (en) 2019-02-21
MY195362A (en) 2023-01-16
PL3103861T3 (pl) 2021-03-22
IL263479B (en) 2020-08-31
SI2732020T1 (sl) 2017-03-31
MY173835A (en) 2020-02-24
ES2829968T3 (es) 2021-06-02
US20170260498A1 (en) 2017-09-14
EA201990887A1 (ru) 2019-08-30
CA2876473C (en) 2021-05-11
IL236073A0 (en) 2015-01-29
KR20190092618A (ko) 2019-08-07
EP2732020B1 (en) 2016-08-10
PT2732020T (pt) 2016-11-10
DK3103861T3 (da) 2020-11-16
US9670456B2 (en) 2017-06-06
DK2732020T3 (en) 2016-11-28
HK1198335A1 (zh) 2015-04-02
JP6220392B2 (ja) 2017-10-25
NZ629083A (en) 2016-11-25
CA2876473A1 (en) 2013-12-27
PL2732020T3 (pl) 2017-06-30
EP2732020A1 (en) 2014-05-21
ES2601429T3 (es) 2017-02-15
KR102008048B1 (ko) 2019-08-06
MX347319B (es) 2017-04-21
JP2017184765A (ja) 2017-10-12
JP6557706B2 (ja) 2019-08-07
IL236073B (en) 2019-01-31
AU2017228547A1 (en) 2017-10-05
ZA201409253B (en) 2022-05-25
CO7151484A2 (es) 2014-12-29
AU2013277532A1 (en) 2015-01-15
IN2014DN10441A (enExample) 2015-08-21
TWI698522B (zh) 2020-07-11
TWI609962B (zh) 2018-01-01

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PC4A Registration of transfer of a eurasian patent by assignment