EA201391149A1 - Пневматическая безмембранная система разделения клеток с переменным давлением (pacs) - Google Patents

Пневматическая безмембранная система разделения клеток с переменным давлением (pacs)

Info

Publication number
EA201391149A1
EA201391149A1 EA201391149A EA201391149A EA201391149A1 EA 201391149 A1 EA201391149 A1 EA 201391149A1 EA 201391149 A EA201391149 A EA 201391149A EA 201391149 A EA201391149 A EA 201391149A EA 201391149 A1 EA201391149 A1 EA 201391149A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pacs
pneumatic
immembrane
separation system
variable pressure
Prior art date
Application number
EA201391149A
Other languages
English (en)
Other versions
EA023614B1 (ru
Inventor
Алайн Пралонг
Ханс Ульрих Делленбах
Original Assignee
Круселл Холланд Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Круселл Холланд Б.В. filed Critical Круселл Холланд Б.В.
Publication of EA201391149A1 publication Critical patent/EA201391149A1/ru
Publication of EA023614B1 publication Critical patent/EA023614B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/12—Apparatus for enzymology or microbiology with sterilisation, filtration or dialysis means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/20—Accessories; Auxiliary operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/58—Parts of membrane modules specifically adapted for single use
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/04—Backflushing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Abstract

Настоящее изобретение предлагает новую систему фильтрации, которая может упоминаться как пневматический переменный сепаратор клеток (PACS), его полезные компоненты и его узлы или наборы деталей, которые могут использоваться для построения системы, и применение системы для фильтрации текучих сред, например, в перфузионных системах для культивирования клеток, содержащих камеру (8), содержащую фильтр, расширительную камеру (17), контроллер (28) потока газа.
EA201391149A 2011-02-10 2012-02-07 Пневматическая безмембранная система разделения клеток с переменным давлением EA023614B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161463095P 2011-02-10 2011-02-10
EP11153995 2011-02-10
EP11183676 2011-10-03
US201161627812P 2011-10-18 2011-10-18
PCT/EP2012/052031 WO2012107436A1 (en) 2011-02-10 2012-02-07 Pneumatic alternating pressure membrane cell separation system

Publications (2)

Publication Number Publication Date
EA201391149A1 true EA201391149A1 (ru) 2013-12-30
EA023614B1 EA023614B1 (ru) 2016-06-30

Family

ID=45569654

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391149A EA023614B1 (ru) 2011-02-10 2012-02-07 Пневматическая безмембранная система разделения клеток с переменным давлением

Country Status (17)

Country Link
US (2) US8845902B2 (ru)
EP (1) EP2673072B1 (ru)
JP (1) JP5893051B2 (ru)
KR (1) KR101890000B1 (ru)
CN (1) CN103347595B (ru)
AU (1) AU2012215514B2 (ru)
BR (1) BR112013019325B1 (ru)
CA (1) CA2824907C (ru)
DK (1) DK2673072T3 (ru)
EA (1) EA023614B1 (ru)
ES (1) ES2529429T3 (ru)
IL (1) IL227833A (ru)
MX (1) MX344465B (ru)
PL (1) PL2673072T3 (ru)
SG (1) SG192611A1 (ru)
WO (1) WO2012107436A1 (ru)
ZA (1) ZA201306752B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013019325B1 (pt) 2011-02-10 2020-12-15 Janssen Vaccines & Prevention B.V Sistema de filtração de fluido e processo para filtrar um fluido
EP3152317B1 (en) * 2014-06-04 2019-01-02 Amgen Inc. Methods for harvesting mammalian cell cultures
EP4166224A1 (en) 2015-08-20 2023-04-19 Cytiva Sweden AB Improved method for enhancing filtration yields in tangential flow filtration system
CN106282001A (zh) * 2016-10-09 2017-01-04 陈静 一种高通量快速捕获提纯循环肿瘤细胞的设备及方法
CN107058086B (zh) * 2017-05-26 2020-07-03 奥凯（苏州）生物技术有限公司 一种防止细胞堵塞培养器的方法及系统
US10774297B2 (en) 2017-08-03 2020-09-15 Repligen Corporation Method of actuation of an alternating tangential flow diaphragm pump
CN111565823B (zh) * 2018-01-12 2023-03-31 富默乐有限公司 切向流过滤tff系统和包括集成泵装置的一次性tff单元
TW202003832A (zh) * 2018-05-04 2020-01-16 美商健臻公司 具有過濾系統的灌注式生物反應器
KR102142479B1 (ko) * 2020-01-09 2020-08-07 주식회사 엠디뮨 세포 압출기 및 세포 압출방법
US20230120489A1 (en) * 2020-03-06 2023-04-20 Yukuan Shang Perfusion module and perfusion culture system
CN111530285A (zh) * 2020-05-26 2020-08-14 英诺维尔智能科技（苏州）有限公司 一种适用于生物制品规模化生产的过滤收集装置
EP4182428A1 (en) 2020-07-20 2023-05-24 Janssen Biotech, Inc. Fluid filtration system

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4502953A (en) * 1983-09-02 1985-03-05 Plasworld, Inc. Water purifying apparatus with air check valve and filter condition indication
US4861498A (en) 1987-12-30 1989-08-29 R & L Filtration Limited Backwash system for filter-thickeners
US5234424A (en) * 1988-12-28 1993-08-10 Alza Corporation Osmotically driven syringe
US5039402A (en) * 1989-11-15 1991-08-13 Himelstein Walter D Water purifier
US5055198A (en) * 1990-03-07 1991-10-08 Shettigar U Ramakrishna Autologous blood recovery membrane system and method
AT396919B (de) * 1992-03-27 1993-12-27 Hochgatterer Josef Wasseraufbereitungsgerät
US5254243A (en) * 1992-06-22 1993-10-19 Whirlpool Corporation Water conditioning system and an electronic control therefor
US5256279A (en) * 1992-07-02 1993-10-26 Carr-Griff, Inc. Liquid storage system with unpressurized reservoir engagable with level sensors
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5911884A (en) * 1996-12-02 1999-06-15 Entre Pure Industries Contamination proof purified water dispenser and method of using same
US6945257B2 (en) * 1997-06-23 2005-09-20 Princeton Trade & Technology Method for cleaning hollow tubing and fibers
US6093312A (en) * 1998-01-22 2000-07-25 Entre Pure, Inc. Ice dispenser with an air-cooled bin
US7288195B2 (en) * 1999-05-28 2007-10-30 Bio/Data Corporation Method and apparatus for directly sampling a fluid for microfiltration
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
AUPR692401A0 (en) * 2001-08-09 2001-08-30 U.S. Filter Wastewater Group, Inc. Method of cleaning membrane modules
EP1424119A3 (en) 2002-11-29 2004-06-16 Taisei Kogyo Co., Ltd. Filter apparatus with cleaning means
US7910074B2 (en) * 2005-10-13 2011-03-22 Beckman Coulter, Inc. System and method for continuously transferring and processing liquids
DE202005018578U1 (de) 2005-11-25 2007-04-05 Kaifel, Rainer Handpumpe in Kombination mit Membranmodulen mit schlauchförmigen Membranen
PT2634243T (pt) 2006-07-14 2017-12-18 Patheon Holdings I B V Método para melhorar a cultura de células
EP2349524B1 (en) 2008-09-24 2014-11-12 Repligen Corporation Screen filter module for alternating flow filtration
US10041049B2 (en) 2008-11-03 2018-08-07 Janssen Vaccines & Prevention B.V. Method for the production of adenoviral vectors
EP2608863A4 (en) * 2010-08-25 2015-08-05 Repligen Corporation FLUID FILTRATION SYSTEMS
BR112013019325B1 (pt) 2011-02-10 2020-12-15 Janssen Vaccines & Prevention B.V Sistema de filtração de fluido e processo para filtrar um fluido

Also Published As

Publication number Publication date
US8845902B2 (en) 2014-09-30
EP2673072A1 (en) 2013-12-18
KR20140004150A (ko) 2014-01-10
PL2673072T3 (pl) 2015-04-30
CN103347595B (zh) 2016-01-20
IL227833A0 (en) 2013-09-30
IL227833A (en) 2017-02-28
BR112013019325A2 (pt) 2018-07-17
JP5893051B2 (ja) 2016-03-23
AU2012215514B2 (en) 2017-04-20
US20130319944A1 (en) 2013-12-05
BR112013019325B1 (pt) 2020-12-15
ES2529429T3 (es) 2015-02-20
MX2013009030A (es) 2013-09-06
CA2824907A1 (en) 2012-08-16
CA2824907C (en) 2020-07-07
SG192611A1 (en) 2013-09-30
WO2012107436A1 (en) 2012-08-16
EA023614B1 (ru) 2016-06-30
EP2673072B1 (en) 2014-11-19
NZ614364A (en) 2015-07-31
AU2012215514A1 (en) 2013-08-29
CN103347595A (zh) 2013-10-09
ZA201306752B (en) 2014-05-28
KR101890000B1 (ko) 2018-08-20
DK2673072T3 (en) 2015-02-16
JP2014514129A (ja) 2014-06-19
US20140342446A1 (en) 2014-11-20
MX344465B (es) 2016-12-14

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM