TWI609866B - 新穎吡唑衍生物 - Google Patents
新穎吡唑衍生物 Download PDFInfo
- Publication number
- TWI609866B TWI609866B TW103107745A TW103107745A TWI609866B TW I609866 B TWI609866 B TW I609866B TW 103107745 A TW103107745 A TW 103107745A TW 103107745 A TW103107745 A TW 103107745A TW I609866 B TWI609866 B TW I609866B
- Authority
- TW
- Taiwan
- Prior art keywords
- pyrazolo
- butyl
- pyrrolidin
- methyl
- pyrimidine
- Prior art date
Links
- 0 *C[n](c1cc(Cl)n2)ncc1c2Cl Chemical compound *C[n](c1cc(Cl)n2)ncc1c2Cl 0.000 description 4
- VRZFCTFTMLLFAD-UHFFFAOYSA-N CC(C)(C)C(N1)=Nc([n](Cc(cc2)ccc2OC)nc2)c2C1=O Chemical compound CC(C)(C)C(N1)=Nc([n](Cc(cc2)ccc2OC)nc2)c2C1=O VRZFCTFTMLLFAD-UHFFFAOYSA-N 0.000 description 1
- IGUIUOOSWDDSFB-UHFFFAOYSA-N CC(C)(C)c1nc(Cl)c(cn[n]2Cc(cc3)ccc3OC)c2n1 Chemical compound CC(C)(C)c1nc(Cl)c(cn[n]2Cc(cc3)ccc3OC)c2n1 IGUIUOOSWDDSFB-UHFFFAOYSA-N 0.000 description 1
- WOIDJTAEQHMJIS-UHFFFAOYSA-N CC(C)(C)c1nc(N(CC2)CC2(F)F)c(cn[n]2Cc3c(C(F)(F)F)cccc3)c2n1 Chemical compound CC(C)(C)c1nc(N(CC2)CC2(F)F)c(cn[n]2Cc3c(C(F)(F)F)cccc3)c2n1 WOIDJTAEQHMJIS-UHFFFAOYSA-N 0.000 description 1
- UHCDGNPQERWNGN-UHFFFAOYSA-N CC(C)(C)c1nc(N(CC2)CC2(F)F)c(cn[n]2Cc3cnn[n]3C)c2n1 Chemical compound CC(C)(C)c1nc(N(CC2)CC2(F)F)c(cn[n]2Cc3cnn[n]3C)c2n1 UHCDGNPQERWNGN-UHFFFAOYSA-N 0.000 description 1
- BFVDVMHQZMAVOU-UHFFFAOYSA-N COc1ccc(C[n]2ncc(C#N)c2N)cc1 Chemical compound COc1ccc(C[n]2ncc(C#N)c2N)cc1 BFVDVMHQZMAVOU-UHFFFAOYSA-N 0.000 description 1
- RESMQRUOHBZJCA-UHFFFAOYSA-N O=Cc(c(Cl)nc(Cl)c1)c1Cl Chemical compound O=Cc(c(Cl)nc(Cl)c1)c1Cl RESMQRUOHBZJCA-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13158233 | 2013-03-07 | ||
??13158233.0 | 2013-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW201506023A TW201506023A (zh) | 2015-02-16 |
TWI609866B true TWI609866B (zh) | 2018-01-01 |
Family
ID=47827068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW103107745A TWI609866B (zh) | 2013-03-07 | 2014-03-06 | 新穎吡唑衍生物 |
Country Status (35)
Country | Link |
---|---|
US (2) | US9512132B2 (es) |
EP (1) | EP2964646B1 (es) |
JP (2) | JP6514119B2 (es) |
KR (2) | KR102369407B1 (es) |
CN (1) | CN105143220B (es) |
AR (1) | AR094978A1 (es) |
AU (1) | AU2014224784B2 (es) |
BR (1) | BR112015020795B1 (es) |
CA (1) | CA2897513C (es) |
CL (1) | CL2015002387A1 (es) |
CR (1) | CR20150447A (es) |
CY (1) | CY1118950T1 (es) |
DK (1) | DK2964646T3 (es) |
EA (1) | EA027935B1 (es) |
ES (1) | ES2629751T3 (es) |
HK (1) | HK1213258A1 (es) |
HR (1) | HRP20170919T1 (es) |
HU (1) | HUE034831T2 (es) |
IL (1) | IL240327B (es) |
LT (1) | LT2964646T (es) |
MA (1) | MA38403A1 (es) |
MX (1) | MX363727B (es) |
MY (1) | MY176797A (es) |
NZ (1) | NZ710052A (es) |
PE (1) | PE20151539A1 (es) |
PH (1) | PH12015501843A1 (es) |
PL (1) | PL2964646T3 (es) |
PT (1) | PT2964646T (es) |
RS (1) | RS56148B1 (es) |
SG (1) | SG11201507168XA (es) |
SI (1) | SI2964646T1 (es) |
TW (1) | TWI609866B (es) |
UA (1) | UA118666C2 (es) |
WO (1) | WO2014135507A1 (es) |
ZA (1) | ZA201505073B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201507168XA (en) * | 2013-03-07 | 2015-10-29 | Hoffmann La Roche | Novel pyrazol derivatives |
CA2899168A1 (en) | 2013-03-26 | 2014-10-02 | F. Hoffmann-La Roche Ag | Novel pyridine derivatives |
CA2907691A1 (en) | 2013-05-02 | 2014-11-06 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
PL2991987T3 (pl) | 2013-05-02 | 2018-10-31 | F. Hoffmann-La Roche Ag | Pochodne purynowe jako agoniści receptora CB2 |
PT3483163T (pt) | 2013-09-06 | 2021-08-24 | Hoffmann La Roche | Novos derivados de triazolo[4,5-d]pirimidina como antagonistas de receptor cb2 |
CA2979534A1 (en) * | 2015-03-13 | 2016-09-22 | Abbvie Inc. | (indazol-4-yl)hexahydropyrrolopyrrolones and method of use |
WO2016191935A1 (en) * | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
WO2016192083A1 (en) * | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
EP4108665A1 (en) | 2016-06-23 | 2022-12-28 | F. Hoffmann-La Roche AG | [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor |
JP7090037B2 (ja) | 2016-06-23 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | 新規な[1,2,3]トリアゾロ[4,5-d]ピリミジン誘導体 |
CN109311895B (zh) | 2016-06-23 | 2021-06-18 | 豪夫迈·罗氏有限公司 | 新型[1,2,3]三唑并[4,5-d]嘧啶衍生物 |
EP3475281A1 (en) | 2016-06-23 | 2019-05-01 | H. Hoffnabb-La Roche Ag | Novel [1,2,31triazolo[4,5-d]pyrimidine derivatives |
US20220170826A1 (en) | 2019-03-25 | 2022-06-02 | Nikon Corporation | Cell manipulation device and cell manipulation method |
AU2021341508A1 (en) | 2020-09-10 | 2023-05-25 | Precirix N.V. | Antibody fragment against fap |
WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
CN115246832A (zh) * | 2022-06-15 | 2022-10-28 | 深圳湾实验室 | 一类去泛素化酶usp25和usp28靶向抑制剂及制备和应用 |
Citations (1)
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WO2006047516A2 (en) * | 2004-10-26 | 2006-05-04 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2980677A (en) * | 1961-04-18 | Certificate of correction | ||
WO2001058869A2 (en) * | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
WO2003082191A2 (en) | 2002-03-28 | 2003-10-09 | Merck & Co., Inc. | Substituted 2,3-diphenyl pyridines |
DE10219435A1 (de) * | 2002-05-02 | 2003-11-13 | Bayer Cropscience Ag | Substituierte Pyrazolo-pyrimidin-4-one |
EP2211619A1 (en) | 2007-10-18 | 2010-08-04 | Merck Sharp & Dohme Corp. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
WO2010118367A2 (en) * | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
US9321727B2 (en) | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
UA111640C2 (uk) | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
WO2014005968A1 (en) | 2012-07-04 | 2014-01-09 | F. Hoffmann-La Roche Ag | Novel adamantyl derivatives as cannabinoid receptor 2 agonists |
US9303012B2 (en) | 2012-12-07 | 2016-04-05 | Hoffman-La Roche Inc. | Pyridine-2-amides useful as CB2 agonists |
PE20151073A1 (es) | 2012-12-07 | 2015-07-25 | Hoffmann La Roche | Piridina-2-amidas utiles como agonistas de cb2 |
EP3357918A1 (en) | 2012-12-07 | 2018-08-08 | F. Hoffmann-La Roche AG | Novel pyridine derivatives |
US9512141B2 (en) | 2012-12-07 | 2016-12-06 | Hoffmann-La Roche Inc. | Pyrazine derivatives as CB2 receptor agonists |
SG11201507168XA (en) * | 2013-03-07 | 2015-10-29 | Hoffmann La Roche | Novel pyrazol derivatives |
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